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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei730ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CE2848
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520061 – 957Leucine--tRNA ligaseAdd BLAST957

Proteomic databases

PRIDEiQ8FLM0

Interactioni

Protein-protein interaction databases

STRINGi196164.HMPREF0290_2836

Structurei

3D structure databases

ProteinModelPortaliQ8FLM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi70 – 81"HIGH" regionAdd BLAST12
Motifi727 – 731"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FLM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPSEGTSS SAQSLAYRYT PELANAIERE WQNYWTDKGT FNAPNPVGDL
60 70 80 90 100
APEDGRELPG DKLFVQDMFP YPSGAGLHVG HPLGYIATDV FARYNRMLGK
110 120 130 140 150
NVLHTLGYDA FGLPAEQYAI QTGTHPRTTT MANIENMKRQ LGALGLGHDP
160 170 180 190 200
RRAVASTDPE FYKWTQWIFL QIFNSWFDEE QQKARPISEL IPLLESGEIP
210 220 230 240 250
TRDGADYNGL DRVAKQKAID EFRLVYRSNS TVNWCPGLGT VLANEEVTAD
260 270 280 290 300
GRSERGNFPV FRKNLSQWMM RITAYSDRLI DDLELLDWPE KVKSMQRNWI
310 320 330 340 350
GRSRGAEVDF TAEGETITVF TTRPDTLFGA TYMVLAPEHE LVDVLVSRGT
360 370 380 390 400
GSYDGVDPRW TNGQATPAEA VAAYRASIAA KSDLERQENK DKTGVFLGVH
410 420 430 440 450
ATNPVNGEQI PVFIADYVLT GYGTGAIMAV PAHDDRDYEF ATVFGLPIVE
460 470 480 490 500
VVAGGNIAEA AYTASGESIN SANDQGLDIN GLAMVDAVAR TIEWLEEKQL
510 520 530 540 550
GRGTIQYKLR DWLFARQRYW GEPFPVVYDE DGVAYALPES MLPVELPEVE
560 570 580 590 600
DYKPVSFDPE DADSEPSPPL AKAREWVEVE LDLGDGVKKY TRDTNVMPQW
610 620 630 640 650
AGSSWYQLRY IDPTNDDQFC NLENEAYWTG PRPDVHGPND PGGVDLYVGG
660 670 680 690 700
VEHAVLHLLY SRFWHKVLYD LGYVTSKEPY RRLYNQGYIQ AFAYTDSRGV
710 720 730 740 750
YVPAEEVEEK DGKFFYQGEE VTQEYGKMGK SLKNAVAPDD ICNNYGADTL
760 770 780 790 800
RVYEMSMGPL DTSRPWATKD VVGAQRFLQR LWRLIVDENT GEVLTRDEAL
810 820 830 840 850
TDEDNKHLHR TIAGVRDDYA NLRVNTVVAK LIEYVNYLTK TYPDTIPTGA
860 870 880 890 900
VLPLVVMVSP VAPHIAEELW KKLGHTDTVT YEPFPTFEEK WLTDDEVELP
910 920 930 940 950
VQINGKVRSR ITVAADASQE QIIEVALADE KIALQIEGKN LIKQIVIPGR

MVNLVVK
Length:957
Mass (Da):107,399
Last modified:March 1, 2003 - v1
Checksum:iA6FFBF26AAFBC1FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA Translation: BAC19658.1
RefSeqiWP_006768798.1, NZ_GG700684.1

Genome annotation databases

EnsemblBacteriaiBAC19658; BAC19658; BAC19658
KEGGicef:CE2848

Similar proteinsi

Entry informationi

Entry nameiSYL_COREF
AccessioniPrimary (citable) accession number: Q8FLM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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