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Q8FLM0

- SYL_COREF

UniProt

Q8FLM0 - SYL_COREF

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei730 – 7301ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CE2848
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Leucine--tRNA ligasePRO_0000152006Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196164.CE2848.

Structurei

3D structure databases

ProteinModelPortaliQ8FLM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 8112"HIGH" regionAdd
BLAST
Motifi727 – 7315"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FLM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNPSEGTSS SAQSLAYRYT PELANAIERE WQNYWTDKGT FNAPNPVGDL
60 70 80 90 100
APEDGRELPG DKLFVQDMFP YPSGAGLHVG HPLGYIATDV FARYNRMLGK
110 120 130 140 150
NVLHTLGYDA FGLPAEQYAI QTGTHPRTTT MANIENMKRQ LGALGLGHDP
160 170 180 190 200
RRAVASTDPE FYKWTQWIFL QIFNSWFDEE QQKARPISEL IPLLESGEIP
210 220 230 240 250
TRDGADYNGL DRVAKQKAID EFRLVYRSNS TVNWCPGLGT VLANEEVTAD
260 270 280 290 300
GRSERGNFPV FRKNLSQWMM RITAYSDRLI DDLELLDWPE KVKSMQRNWI
310 320 330 340 350
GRSRGAEVDF TAEGETITVF TTRPDTLFGA TYMVLAPEHE LVDVLVSRGT
360 370 380 390 400
GSYDGVDPRW TNGQATPAEA VAAYRASIAA KSDLERQENK DKTGVFLGVH
410 420 430 440 450
ATNPVNGEQI PVFIADYVLT GYGTGAIMAV PAHDDRDYEF ATVFGLPIVE
460 470 480 490 500
VVAGGNIAEA AYTASGESIN SANDQGLDIN GLAMVDAVAR TIEWLEEKQL
510 520 530 540 550
GRGTIQYKLR DWLFARQRYW GEPFPVVYDE DGVAYALPES MLPVELPEVE
560 570 580 590 600
DYKPVSFDPE DADSEPSPPL AKAREWVEVE LDLGDGVKKY TRDTNVMPQW
610 620 630 640 650
AGSSWYQLRY IDPTNDDQFC NLENEAYWTG PRPDVHGPND PGGVDLYVGG
660 670 680 690 700
VEHAVLHLLY SRFWHKVLYD LGYVTSKEPY RRLYNQGYIQ AFAYTDSRGV
710 720 730 740 750
YVPAEEVEEK DGKFFYQGEE VTQEYGKMGK SLKNAVAPDD ICNNYGADTL
760 770 780 790 800
RVYEMSMGPL DTSRPWATKD VVGAQRFLQR LWRLIVDENT GEVLTRDEAL
810 820 830 840 850
TDEDNKHLHR TIAGVRDDYA NLRVNTVVAK LIEYVNYLTK TYPDTIPTGA
860 870 880 890 900
VLPLVVMVSP VAPHIAEELW KKLGHTDTVT YEPFPTFEEK WLTDDEVELP
910 920 930 940 950
VQINGKVRSR ITVAADASQE QIIEVALADE KIALQIEGKN LIKQIVIPGR

MVNLVVK
Length:957
Mass (Da):107,399
Last modified:March 1, 2003 - v1
Checksum:iA6FFBF26AAFBC1FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC19658.1.
RefSeqiNP_739458.1. NC_004369.1.
WP_006768798.1. NZ_GG700684.1.

Genome annotation databases

EnsemblBacteriaiBAC19658; BAC19658; BAC19658.
GeneIDi1033530.
KEGGicef:CE2848.
PATRICi21491841. VBICorEff9312_2807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC19658.1 .
RefSeqi NP_739458.1. NC_004369.1.
WP_006768798.1. NZ_GG700684.1.

3D structure databases

ProteinModelPortali Q8FLM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE2848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC19658 ; BAC19658 ; BAC19658 .
GeneIDi 1033530.
KEGGi cef:CE2848.
PATRICi 21491841. VBICorEff9312_2807.

Phylogenomic databases

HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiSYL_COREF
AccessioniPrimary (citable) accession number: Q8FLM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3