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Reviewed, UniProtKB/Swiss-Prot Q8FKI8 (BETB_ECOL6)

Last modified February 9, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8
Gene names
Name: betB
Ordered Locus Names: c0432
OrganismEscherichia coli O6 [Complete proteome] [HAMAP]
Taxonomic identifier217992 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 490489Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_0000056543

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FKI8-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: A88D39DFB2F296A7

FASTA49052,908
        10         20         30         40         50         60 
MSRMAEQQLY IHGGYTSATS GRTFETINPA NGNVLATVQA AGREDVDRAV KSAQQGQKIW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVDILR ERNDELAKLE TLDTGKAYSE TSTVDIVTGA DVLEYYAGLI 

       130        140        150        160        170        180 
PALEGSQIPL RETSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TPLTALKLAE IYSEAGLPDG VFNVLPGVGA ETGQYLTDHP GIAKVSFTGG VASGKKVMAN 

       250        260        270        280        290        300 
SAASSLKEVT MELGGKSPLI VFDDADLDLA ADIAMMANFF SSGQVCTNGT RVFVPTKCKA 

       310        320        330        340        350        360 
AFEQKVLARV ERIRAGDVFD PQTNFGPLVS FPHRDNVLRY IAKGKEEGAR VLCGGNVLKG 

       370        380        390        400        410        420 
DSFDNGAWVA PTVFTDCSDD MTIVREEIFG PVMSILTYES EDEVIRRAND TDYGLAAGIV 

       430        440        450        460        470        480 
TADLNRAHRV IHQLEAGICW INTWGESPAE IPVGGYKHSG IGRENGVMTL QSYTQVKSIQ 

       490 
VEMAKFQSIF 

« Hide

References

[1]"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli."
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R.
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014075 Genomic DNA. Translation: AAN78913.1. Different initiation.
RefSeqNP_752369.1.

3D structure databases

SMRQ8FKI8. Positions 7-490.
ModBaseSearch...

Genome annotation databases

GeneID1036263.
GenomeReviewsGene locus c0432 in contig AE014075_GR.
KEGGecc:c0432.
NMPDRfig|199310.1.peg.413.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMATDCRDEM.

Enzyme and pathway databases

BRENDA1.2.1.8. 292881.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_ECOL6
AccessionPrimary (citable) accession number: Q8FKI8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 48 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents