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Q8FK76

- GLSA1_ECOL6

UniProt

Q8FK76 - GLSA1_ECOL6

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Protein
Glutaminase 1
Gene
glsA1, c0605
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL199310:C0605-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 1 (EC:3.5.1.2)
Gene namesi
Name:glsA1
Ordered Locus Names:c0605
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Glutaminase 1UniRule annotation
PRO_0000110611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei294 – 2941N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi199310.c0605.

Structurei

3D structure databases

ProteinModelPortaliQ8FK76.
SMRiQ8FK76. Positions 2-310.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

HOGENOMiHOG000216890.
KOiK01425.
OMAiEDRWARI.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FK76-1 [UniParc]FASTAAdd to Basket

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MLDANKLQQA VDQAYTQFHS LNGGQNADYI PFLANVPGQL AAVAIVTSDG    50
NVYSAGDSDY RFALESISKV CTLALALEDV GPQAVQDKVG ADPTGLPFNS 100
VIALELHGGK PLSPLVNAGA IATTSLINAE NTEQRWQRIL HIQQQLAGEQ 150
VALSDEVNQS EQTTNFHNRA IAWLLYSAGY LYCDAMEACD VYTRQCSTLI 200
NTIELATLGA TLAAGGVNPL THKRVLQADN VPYILAEMMM EGLYGRSGDW 250
AYRVGLPGKS GVGGGILAVV PGVMGIAAFS PPLDEEGNSV RGQKMVASVA 300
KQLGYNVFKG 310
Length:310
Mass (Da):32,889
Last modified:March 1, 2003 - v1
Checksum:i9F1C3706BEFC4296
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN79083.1.
RefSeqiNP_752539.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79083; AAN79083; c0605.
GeneIDi1036278.
KEGGiecc:c0605.
PATRICi18279248. VBIEscCol75197_0569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN79083.1 .
RefSeqi NP_752539.1. NC_004431.1.

3D structure databases

ProteinModelPortali Q8FK76.
SMRi Q8FK76. Positions 2-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c0605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN79083 ; AAN79083 ; c0605 .
GeneIDi 1036278.
KEGGi ecc:c0605.
PATRICi 18279248. VBIEscCol75197_0569.

Phylogenomic databases

HOGENOMi HOG000216890.
KOi K01425.
OMAi EDRWARI.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci ECOL199310:C0605-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiGLSA1_ECOL6
AccessioniPrimary (citable) accession number: Q8FK76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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