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Protein

HTH-type transcriptional regulator CueR

Gene

cueR

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Copper(1+)By similarity1
Metal bindingi120Copper(1+)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciECOL199310:C0607-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CueR
Alternative name(s):
Copper efflux regulator
Copper export regulator
Gene namesi
Name:cueR
Ordered Locus Names:c0607
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981121 – 135HTH-type transcriptional regulator CueRAdd BLAST135

Proteomic databases

PRIDEiQ8FK74

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi199310.c0607

Structurei

3D structure databases

ProteinModelPortaliQ8FK74
SMRiQ8FK74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Domaini

It contains a N-terminal DNA binding region and a C-terminal metal binding region.By similarity

Phylogenomic databases

eggNOGiENOG4108Z6Z Bacteria
COG0789 LUCA
HOGENOMiHOG000266076
KOiK19591
OMAiYDERAVH

Family and domain databases

CDDicd01108 HTH_CueR, 1 hit
InterProiView protein in InterPro
IPR011789 CueR
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02044 CueR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FK74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISDVAKIT GLTSKAIRFY EEKGLVTPPM RSENGYRTYT QQHLNELTLL
60 70 80 90 100
RQARQVGFNL EESGELVNLF NDPQRHSADV KRRTLEKVAE IEQHIEELQS
110 120 130
MRNQLLALAN ACPGDDSADC PIIENLSGCC HHRAG
Length:135
Mass (Da):15,206
Last modified:March 1, 2003 - v1
Checksum:iADA0DAEA2C2B0862
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA Translation: AAN79085.1
RefSeqiWP_001026743.1, NC_004431.1

Genome annotation databases

EnsemblBacteriaiAAN79085; AAN79085; c0607
KEGGiecc:c0607

Similar proteinsi

Entry informationi

Entry nameiCUER_ECOL6
AccessioniPrimary (citable) accession number: Q8FK74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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