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Q8FJS1

- GAL1_ECOL6

UniProt

Q8FJS1 - GAL1_ECOL6

Protein

Galactokinase

Gene

galK

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).UniRule annotation

    Catalytic activityi

    ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei28 – 281Transition state stabilizerUniRule annotation
    Metal bindingi130 – 1301MagnesiumUniRule annotation
    Metal bindingi162 – 1621MagnesiumUniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Binding sitei223 – 2231SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi124 – 1307ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. galactokinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. galactose metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Galactose metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL199310:C0833-MONOMER.
    UniPathwayiUPA00214.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GalactokinaseUniRule annotation (EC:2.7.1.6UniRule annotation)
    Alternative name(s):
    Galactose kinaseUniRule annotation
    Gene namesi
    Name:galKUniRule annotation
    Ordered Locus Names:c0833
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 382381GalactokinasePRO_0000184609Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c0833.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FJS1.
    SMRiQ8FJS1. Positions 3-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 374Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the GHMP kinase family. GalK subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000241100.
    KOiK00849.
    OMAiVMPCAIN.
    OrthoDBiEOG6DG2SH.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00246. Galactokinase.
    InterProiIPR000705. Galactokinase.
    IPR022963. Galactokinase_bac.
    IPR019741. Galactokinase_CS.
    IPR019539. GalKase_gal-bd.
    IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006206. Mevalonate/galactokinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF10509. GalKase_gal_bdg. 1 hit.
    PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000530. Galactokinase. 1 hit.
    PRINTSiPR00473. GALCTOKINASE.
    PR00959. MEVGALKINASE.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00131. gal_kin. 1 hit.
    PROSITEiPS00106. GALACTOKINASE. 1 hit.
    PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8FJS1-1 [UniParc]FASTAAdd to Basket

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    MSLKEKTQSL FANAFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY    50
    QTVISCAPRD DRKVRVMAAD YENQLDEFSL DAPIVAHENY QWANYVRGVV 100
    KHLQLRNNSF GGVDMVISGN VPQGAGLSSS ASLEVAVGTV LQQLYHLPLD 150
    GAQIALNGQE AENQFVGCNC GIMDQLISAL GKKDHALLID CRSLGTKAVS 200
    MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP ALRDVTIEEF 250
    NAVAHELDPI VAKRVRHILT ENARTVEAAS ALEQGDLKRM GELMAESHAS 300
    MRDDFEITVP QIDTLVEIVK AVIGDKGGVR MTGGGFGGCI VALFPEELVP 350
    AVQQAVAEQY EAKTGIKETF YVCKPSQGAG QC 382
    Length:382
    Mass (Da):41,476
    Last modified:January 23, 2007 - v3
    Checksum:iBE4B6CE6FC48F9A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79306.1.
    RefSeqiNP_752763.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN79306; AAN79306; c0833.
    GeneIDi1038288.
    KEGGiecc:c0833.
    PATRICi18279725. VBIEscCol75197_0792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79306.1 .
    RefSeqi NP_752763.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali Q8FJS1.
    SMRi Q8FJS1. Positions 3-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c0833.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN79306 ; AAN79306 ; c0833 .
    GeneIDi 1038288.
    KEGGi ecc:c0833.
    PATRICi 18279725. VBIEscCol75197_0792.

    Phylogenomic databases

    HOGENOMi HOG000241100.
    KOi K00849.
    OMAi VMPCAIN.
    OrthoDBi EOG6DG2SH.

    Enzyme and pathway databases

    UniPathwayi UPA00214 .
    BioCyci ECOL199310:C0833-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00246. Galactokinase.
    InterProi IPR000705. Galactokinase.
    IPR022963. Galactokinase_bac.
    IPR019741. Galactokinase_CS.
    IPR019539. GalKase_gal-bd.
    IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006206. Mevalonate/galactokinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF10509. GalKase_gal_bdg. 1 hit.
    PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000530. Galactokinase. 1 hit.
    PRINTSi PR00473. GALCTOKINASE.
    PR00959. MEVGALKINASE.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00131. gal_kin. 1 hit.
    PROSITEi PS00106. GALACTOKINASE. 1 hit.
    PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiGAL1_ECOL6
    AccessioniPrimary (citable) accession number: Q8FJS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3