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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL199310:C1054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:c1054
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

Q8FJB1:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 162HelicalUniRule annotationAdd BLAST23
Transmembranei167 – 186HelicalUniRule annotationAdd BLAST20
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925781 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi199310.c1054.

Structurei

3D structure databases

ProteinModelPortaliQ8FJB1.
SMRiQ8FJB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FJB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP
60 70 80 90 100
LLDDGFGKTD RSVLMWMPLV VIGLMILRGI TSYISSYCIS WVSGKVVMTM
110 120 130 140 150
RRRLFGHMMG MPVSFFDKQS TGTLLSRITY DSEQVASSSS GALITVVREG
160 170 180 190 200
ASIIGLFIMM FYYSWQLSII LIVLAPIVSI AIRVVSKRFR NISKNMQNTM
210 220 230 240 250
GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ GMKMVSASSI
260 270 280 290 300
SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS
310 320 330 340 350
LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT
360 370 380 390 400
YPGRDVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI
410 420 430 440 450
LMDGHDLREY TLASLRNQVA LVSQNVHLFN DTVANNIAYA RTEQYSREQI
460 470 480 490 500
EEAARMAYAM DFINKMDNGL DTVIGENGVL LSGGQRQRIA IARALLRDSP
510 520 530 540 550
ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV
560 570 580
VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ
Length:582
Mass (Da):64,507
Last modified:March 1, 2003 - v1
Checksum:iFA52A59B80B5F975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79524.1.
RefSeqiWP_000551259.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79524; AAN79524; c1054.
KEGGiecc:c1054.

Similar proteinsi

Entry informationi

Entry nameiMSBA_ECOL6
AccessioniPrimary (citable) accession number: Q8FJB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families