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Q8FJ14

- Q8FJ14_ECOL6

UniProt

Q8FJ14 - Q8FJ14_ECOL6

Protein
Submitted name:

3-oxoacyl-[acyl-carrier protein] reductase

Gene

c1187

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871NADP; via carbonyl oxygenImported
    Binding sitei153 – 1531NADPImported
    Binding sitei157 – 1571NADPImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPImported
    Nucleotide bindingi34 – 363NADPImported
    Nucleotide bindingi60 – 612NADPImported
    Nucleotide bindingi186 – 1883NADPImported

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
    2. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    NADPImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciECOL199310:C1187-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-oxoacyl-[acyl-carrier protein] reductaseImported (EC:1.1.1.100Imported)
    Gene namesi
    Ordered Locus Names:c1187Imported
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c1187.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IIUX-ray2.10A/B/C/D1-243[»]
    4IIVX-ray2.50A/B/C/D1-243[»]
    ProteinModelPortaliQ8FJ14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

    Phylogenomic databases

    KOiK00059.
    OMAiVASKENC.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR011285. FabG-rel.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01831. fabG_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FJ14-1 [UniParc]FASTAAdd to Basket

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    MSRSVLVTGA SKGIGRAIAC QLAADGFNIG VHYHRDAAGA QETLNAIVAN    50
    GGNGRLLSFD VANREQCREV LEHEIAQHGA WYGVVSNAGI ARDAAFPALS 100
    NDDWDAVIHT NLDSFYNVIQ PCIMPMIGAR QGGRIITLSS VSGVMGNRGQ 150
    VNYSAAKAGI IGATKALAIE LAKRKITVNC IAPGLIDTGM IEMEESALKE 200
    AMSMIPMKRM GQAEEVAGLA SYLMSDIAGY VTRQVISING GML 243
    Length:243
    Mass (Da):25,638
    Last modified:March 1, 2003 - v1
    Checksum:i7D5543DC46FA151F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79649.1.
    RefSeqiNP_753106.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN79649; AAN79649; c1187.
    GeneIDi1040314.
    KEGGiecc:c1187.
    PATRICi18280400. VBIEscCol75197_1127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79649.1 .
    RefSeqi NP_753106.1. NC_004431.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IIU X-ray 2.10 A/B/C/D 1-243 [» ]
    4IIV X-ray 2.50 A/B/C/D 1-243 [» ]
    ProteinModelPortali Q8FJ14.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c1187.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN79649 ; AAN79649 ; c1187 .
    GeneIDi 1040314.
    KEGGi ecc:c1187.
    PATRICi 18280400. VBIEscCol75197_1127.

    Phylogenomic databases

    KOi K00059.
    OMAi VASKENC.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    BioCyci ECOL199310:C1187-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR011285. FabG-rel.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01831. fabG_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPECImported.
    2. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.1 A resolution."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH NADP.
    3. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.5 A resolution."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiQ8FJ14_ECOL6
    AccessioniPrimary (citable) accession number: Q8FJ14
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3