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Protein
Submitted name:

3-oxoacyl-[acyl-carrier protein] reductase

Gene

c1187

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871NADP; via carbonyl oxygenCombined sources
Binding sitei153 – 1531NADPCombined sources
Binding sitei157 – 1571NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPCombined sources
Nucleotide bindingi34 – 363NADPCombined sources
Nucleotide bindingi60 – 612NADPCombined sources
Nucleotide bindingi186 – 1883NADPCombined sources

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciECOL199310:C1187-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
3-oxoacyl-[acyl-carrier protein] reductaseImported (EC:1.1.1.100Imported)
Gene namesi
Ordered Locus Names:c1187Imported
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi199310.c1187.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IIUX-ray2.10A/B/C/D1-243[»]
4IIVX-ray2.50A/B/C/D1-243[»]
ProteinModelPortaliQ8FJ14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

KOiK00059.
OMAiWERIINI.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR011285. FabG-rel.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01831. fabG_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FJ14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSVLVTGA SKGIGRAIAC QLAADGFNIG VHYHRDAAGA QETLNAIVAN
60 70 80 90 100
GGNGRLLSFD VANREQCREV LEHEIAQHGA WYGVVSNAGI ARDAAFPALS
110 120 130 140 150
NDDWDAVIHT NLDSFYNVIQ PCIMPMIGAR QGGRIITLSS VSGVMGNRGQ
160 170 180 190 200
VNYSAAKAGI IGATKALAIE LAKRKITVNC IAPGLIDTGM IEMEESALKE
210 220 230 240
AMSMIPMKRM GQAEEVAGLA SYLMSDIAGY VTRQVISING GML
Length:243
Mass (Da):25,638
Last modified:February 28, 2003 - v1
Checksum:i7D5543DC46FA151F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79649.1.
RefSeqiNP_753106.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79649; AAN79649; c1187.
GeneIDi1040314.
KEGGiecc:c1187.
PATRICi18280400. VBIEscCol75197_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79649.1.
RefSeqiNP_753106.1. NC_004431.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IIUX-ray2.10A/B/C/D1-243[»]
4IIVX-ray2.50A/B/C/D1-243[»]
ProteinModelPortaliQ8FJ14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c1187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN79649; AAN79649; c1187.
GeneIDi1040314.
KEGGiecc:c1187.
PATRICi18280400. VBIEscCol75197_1127.

Phylogenomic databases

KOiK00059.
OMAiWERIINI.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

BioCyciECOL199310:C1187-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR011285. FabG-rel.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01831. fabG_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPECImported.
  2. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.1 A resolution."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.5 A resolution."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ8FJ14_ECOL6
AccessioniPrimary (citable) accession number: Q8FJ14
Entry historyi
Integrated into UniProtKB/TrEMBL: February 28, 2003
Last sequence update: February 28, 2003
Last modified: January 6, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.