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Q8FJ14

- Q8FJ14_ECOL6

UniProt

Q8FJ14 - Q8FJ14_ECOL6

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Protein
Submitted name:

3-oxoacyl-[acyl-carrier protein] reductase

Gene

c1187

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871NADP; via carbonyl oxygenImported
Binding sitei153 – 1531NADPImported
Binding sitei157 – 1571NADPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPImported
Nucleotide bindingi34 – 363NADPImported
Nucleotide bindingi60 – 612NADPImported
Nucleotide bindingi186 – 1883NADPImported

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciECOL199310:C1187-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
3-oxoacyl-[acyl-carrier protein] reductaseImported (EC:1.1.1.100Imported)
Gene namesi
Ordered Locus Names:c1187Imported
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi199310.c1187.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IIUX-ray2.10A/B/C/D1-243[»]
4IIVX-ray2.50A/B/C/D1-243[»]
ProteinModelPortaliQ8FJ14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

KOiK00059.
OMAiVASKENC.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR011285. FabG-rel.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01831. fabG_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FJ14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRSVLVTGA SKGIGRAIAC QLAADGFNIG VHYHRDAAGA QETLNAIVAN
60 70 80 90 100
GGNGRLLSFD VANREQCREV LEHEIAQHGA WYGVVSNAGI ARDAAFPALS
110 120 130 140 150
NDDWDAVIHT NLDSFYNVIQ PCIMPMIGAR QGGRIITLSS VSGVMGNRGQ
160 170 180 190 200
VNYSAAKAGI IGATKALAIE LAKRKITVNC IAPGLIDTGM IEMEESALKE
210 220 230 240
AMSMIPMKRM GQAEEVAGLA SYLMSDIAGY VTRQVISING GML
Length:243
Mass (Da):25,638
Last modified:March 1, 2003 - v1
Checksum:i7D5543DC46FA151F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN79649.1.
RefSeqiNP_753106.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79649; AAN79649; c1187.
GeneIDi1040314.
KEGGiecc:c1187.
PATRICi18280400. VBIEscCol75197_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN79649.1 .
RefSeqi NP_753106.1. NC_004431.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IIU X-ray 2.10 A/B/C/D 1-243 [» ]
4IIV X-ray 2.50 A/B/C/D 1-243 [» ]
ProteinModelPortali Q8FJ14.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c1187.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN79649 ; AAN79649 ; c1187 .
GeneIDi 1040314.
KEGGi ecc:c1187.
PATRICi 18280400. VBIEscCol75197_1127.

Phylogenomic databases

KOi K00059.
OMAi VASKENC.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

BioCyci ECOL199310:C1187-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR011285. FabG-rel.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01831. fabG_rel. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPECImported.
  2. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.1 A resolution."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.5 A resolution."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ8FJ14_ECOL6
AccessioniPrimary (citable) accession number: Q8FJ14
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3