Q8FIN3 (THIK_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine kinase
EC=2.7.1.89

Gene names

Name:	thiK
Ordered Locus Names:	c1379

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

199310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of thiamine to thiamine phosphate By similarity. HAMAP-Rule MF_01604
Catalytic activity	ATP + thiamine = ADP + thiamine phosphate. HAMAP-Rule MF_01604
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from thiamine: step 1/1. HAMAP-Rule MF_01604
Sequence similarities	Belongs to the thiamine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	thiamine diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway thiamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Thiamine kinase HAMAP-Rule MF_01604		PRO_0000218058

Sequences

	Sequence		Length	Mass (Da)
	Q8FIN3 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: ED7FB1F418F7BC65	FASTA	274	32,441
	10 20 30 40 50 60 MPFRSNNPLT RDELLSRFFP QFHPVTTFNS GLSGGSFLIE HQGQRFVVRQ PHDPDAPQSA 70 80 90 100 110 120 FLRQYRALSQ LPACIAPKPH LYLRDWMVVD YLPGEVKTYL PDTNELAGLL YYLHQQPRFG 130 140 150 160 170 180 WRITLLPLLE LYWQQSDPAR RTVGWLRMLK RLRKAREPRL LRLSPLHMDV HAGNLVHSAS 190 200 210 220 230 240 GLKLIDWEYA GDGDIALELA AVWVENTDQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL 250 260 270 MLKAGWFEYR WRQTGDQQFI RLADDTWRQL LIKQ

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN79849.1.
RefSeq	NP_753289.1. NC_004431.1.
3D structure databases
ProteinModelPortal	Q8FIN3.
ModBase	Search...
Protein-protein interaction databases
STRING	199310.c1379.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN79849; AAN79849; c1379.
GeneID	1035078.
KEGG	ecc:c1379.
PATRIC	18280767. VBIEscCol75197_1308.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000219316.
KO	K07251.
OMA	DYLVLMW.
ProtClustDB	PRK10271.
Enzyme and pathway databases
UniPathway	UPA00060; UER00596.
Family and domain databases
HAMAP	MF_01604. Thiamine_kinase.
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR011009. Kinase-like_dom. IPR014093. Thiamine_kinase. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR02721. ycfN_thiK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIK_ECOL6

Accession

Primary (citable) accession number: Q8FIN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program