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Q8FIN3

- THIK_ECOL6

UniProt

Q8FIN3 - THIK_ECOL6

Protein

Thiamine kinase

Gene

thiK

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of thiamine to thiamine phosphate.UniRule annotation

    Catalytic activityi

    ATP + thiamine = ADP + thiamine phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thiamine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. thiamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL199310:C1379-MONOMER.
    UniPathwayiUPA00060; UER00596.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamine kinaseUniRule annotation (EC:2.7.1.89UniRule annotation)
    Gene namesi
    Name:thiKUniRule annotation
    Ordered Locus Names:c1379
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Thiamine kinasePRO_0000218058Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c1379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FIN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiamine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000219316.
    KOiK07251.
    OMAiHAGNIIH.
    OrthoDBiEOG63NMG9.

    Family and domain databases

    HAMAPiMF_01604. Thiamine_kinase.
    InterProiIPR002575. Aminoglycoside_PTrfase.
    IPR011009. Kinase-like_dom.
    IPR014093. Thiamine_kinase.
    [Graphical view]
    PfamiPF01636. APH. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    TIGRFAMsiTIGR02721. ycfN_thiK. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FIN3-1 [UniParc]FASTAAdd to Basket

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    MPFRSNNPLT RDELLSRFFP QFHPVTTFNS GLSGGSFLIE HQGQRFVVRQ    50
    PHDPDAPQSA FLRQYRALSQ LPACIAPKPH LYLRDWMVVD YLPGEVKTYL 100
    PDTNELAGLL YYLHQQPRFG WRITLLPLLE LYWQQSDPAR RTVGWLRMLK 150
    RLRKAREPRL LRLSPLHMDV HAGNLVHSAS GLKLIDWEYA GDGDIALELA 200
    AVWVENTDQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL MLKAGWFEYR 250
    WRQTGDQQFI RLADDTWRQL LIKQ 274
    Length:274
    Mass (Da):32,441
    Last modified:March 1, 2003 - v1
    Checksum:iED7FB1F418F7BC65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79849.1.
    RefSeqiNP_753289.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN79849; AAN79849; c1379.
    GeneIDi1035078.
    KEGGiecc:c1379.
    PATRICi18280767. VBIEscCol75197_1308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79849.1 .
    RefSeqi NP_753289.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali Q8FIN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c1379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN79849 ; AAN79849 ; c1379 .
    GeneIDi 1035078.
    KEGGi ecc:c1379.
    PATRICi 18280767. VBIEscCol75197_1308.

    Phylogenomic databases

    HOGENOMi HOG000219316.
    KOi K07251.
    OMAi HAGNIIH.
    OrthoDBi EOG63NMG9.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00596 .
    BioCyci ECOL199310:C1379-MONOMER.

    Family and domain databases

    HAMAPi MF_01604. Thiamine_kinase.
    InterProi IPR002575. Aminoglycoside_PTrfase.
    IPR011009. Kinase-like_dom.
    IPR014093. Thiamine_kinase.
    [Graphical view ]
    Pfami PF01636. APH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    TIGRFAMsi TIGR02721. ycfN_thiK. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiTHIK_ECOL6
    AccessioniPrimary (citable) accession number: Q8FIN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3