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Q8FIN3 (THIK_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine kinase

EC=2.7.1.89
Gene names
Name:thiK
Ordered Locus Names:c1379
OrganismEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier199310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of thiamine to thiamine phosphate By similarity. HAMAP-Rule MF_01604

Catalytic activity

ATP + thiamine = ADP + thiamine phosphate. HAMAP-Rule MF_01604

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from thiamine: step 1/1. HAMAP-Rule MF_01604

Sequence similarities

Belongs to the thiamine kinase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthiamine diphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

thiamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thiamine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Thiamine kinase HAMAP-Rule MF_01604
PRO_0000218058

Sequences

Sequence LengthMass (Da)Tools
Q8FIN3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: ED7FB1F418F7BC65

FASTA27432,441
        10         20         30         40         50         60 
MPFRSNNPLT RDELLSRFFP QFHPVTTFNS GLSGGSFLIE HQGQRFVVRQ PHDPDAPQSA 

        70         80         90        100        110        120 
FLRQYRALSQ LPACIAPKPH LYLRDWMVVD YLPGEVKTYL PDTNELAGLL YYLHQQPRFG 

       130        140        150        160        170        180 
WRITLLPLLE LYWQQSDPAR RTVGWLRMLK RLRKAREPRL LRLSPLHMDV HAGNLVHSAS 

       190        200        210        220        230        240 
GLKLIDWEYA GDGDIALELA AVWVENTDQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL 

       250        260        270 
MLKAGWFEYR WRQTGDQQFI RLADDTWRQL LIKQ 

« Hide

References

[1]"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli."
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R.
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014075 Genomic DNA. Translation: AAN79849.1.
RefSeqNP_753289.1. NC_004431.1.

3D structure databases

ProteinModelPortalQ8FIN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING199310.c1379.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN79849; AAN79849; c1379.
GeneID1035078.
KEGGecc:c1379.
PATRIC18280767. VBIEscCol75197_1308.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000219316.
KOK07251.
OMAHAGNIIH.
OrthoDBEOG63NMG9.
ProtClustDBPRK10271.

Enzyme and pathway databases

BioCycECOL199310:C1379-MONOMER.
UniPathwayUPA00060; UER00596.

Family and domain databases

HAMAPMF_01604. Thiamine_kinase.
InterProIPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
IPR014093. Thiamine_kinase.
[Graphical view]
PfamPF01636. APH. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
TIGRFAMsTIGR02721. ycfN_thiK. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIK_ECOL6
AccessionPrimary (citable) accession number: Q8FIN3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways