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Q8FHV4

- RLUB_ECOL6

UniProt

Q8FHV4 - RLUB_ECOL6

Protein

Ribosomal large subunit pseudouridine synthase B

Gene

rluB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei110 – 1101NucleophileBy similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciECOL199310:C1734-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase B (EC:5.4.99.22)
    Alternative name(s):
    23S rRNA pseudouridine(2605) synthase
    rRNA pseudouridylate synthase B
    rRNA-uridine isomerase B
    Gene namesi
    Name:rluB
    Ordered Locus Names:c1734
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Ribosomal large subunit pseudouridine synthase BPRO_0000099984Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c1734.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FHV4.
    SMRiQ8FHV4. Positions 2-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 7573S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RsuA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000044954.
    KOiK06178.
    OMAiARSQKIR.
    OrthoDBiEOG6130DV.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
    IPR018496. PsdUridine_synth_RsuA/RluB_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
    PROSITEiPS01149. PSI_RSU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FHV4-1 [UniParc]FASTAAdd to Basket

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    MSEKLQKVLA RAGHGSRREI ESIIEAGRVS VDGKIAKLGD RVEITPGLKI    50
    RIDGHLISVR ESAEQICRVL AYYKPEGELC TRNDPEGRPT VFDRLPKLRG 100
    ARWIAVGRLD VNTCGLLLFT TDGELANRLM HPSREVEREY AVRVFGQVDD 150
    AKLRDLSRGV QLEDGPAAFK TIKFSGGEGI NQWYNVTLTE GRNREVRRLW 200
    EAVGVQVSRL IRVRYGDIPL PKGLPRGGWT ELDLAQTNYL RELVELPPET 250
    SSKVAVEKDR RRMKANQIRR AVKRHSQVSG GRRSGGRNNN G 291
    Length:291
    Mass (Da):32,725
    Last modified:March 1, 2003 - v1
    Checksum:iC31DF8F0C5CB5578
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80200.1.
    RefSeqiNP_753638.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80200; AAN80200; c1734.
    GeneIDi1035518.
    KEGGiecc:c1734.
    PATRICi18281390. VBIEscCol75197_1614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80200.1 .
    RefSeqi NP_753638.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali Q8FHV4.
    SMRi Q8FHV4. Positions 2-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c1734.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80200 ; AAN80200 ; c1734 .
    GeneIDi 1035518.
    KEGGi ecc:c1734.
    PATRICi 18281390. VBIEscCol75197_1614.

    Phylogenomic databases

    HOGENOMi HOG000044954.
    KOi K06178.
    OMAi ARSQKIR.
    OrthoDBi EOG6130DV.

    Enzyme and pathway databases

    BioCyci ECOL199310:C1734-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
    IPR018496. PsdUridine_synth_RsuA/RluB_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00093. TIGR00093. 1 hit.
    PROSITEi PS01149. PSI_RSU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiRLUB_ECOL6
    AccessioniPrimary (citable) accession number: Q8FHV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3