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Q8FHD0

- Q8FHD0_ECOL6

UniProt

Q8FHD0 - Q8FHD0_ECOL6

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Protein
Submitted name:

Hypothetical oxidoreductase ydfI

Gene
c1968
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 322NADImported
Nucleotide bindingi58 – 603NADImported
Nucleotide bindingi183 – 1842NADImported
Nucleotide bindingi224 – 2263NADImported

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. mannitol metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationsImported

Keywords - Ligandi

NADSAAS annotationsImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciECOL199310:C1968-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Hypothetical oxidoreductase ydfIImported (EC:1.-.-.-Imported)
Gene namesi
Ordered Locus Names:c1968Imported
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi199310.c1968.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IM7X-ray1.90A1-486[»]
ProteinModelPortaliQ8FHD0.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000202982.
KOiK00540.
OMAiNFFRAHE.
OrthoDBiEOG6X9MNH.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FHD0-1 [UniParc]FASTAAdd to Basket

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MGNHLLSAKA TLPVYDRNNL APRIVHLGFG AFHRAHQGVY ADILATEHFS    50
DWGYYEVNLI GGEQQIADLQ QQDNLYTVAE MSADAWTARV VGVVKKALHV 100
QIDGLETVLA AMCEPQIAIV SLTITEKGYF HSPATGQLML DHPMVVADVQ 150
NPHQPKTATG VIVEALARRK AAGLPAFTVM SCDNMPENGH VMRDVVTSYA 200
QAIDVKLAQW IEDNVTFPST MVDRIVPAVT EDTLAKIEQL TGVRDAAGVA 250
CEPFRQWVIE DNFVAGRPEW EKAGAELVSD VLPYEEMKLR MLNGSHSFLA 300
YLGYLAGYQH INDCMEDEHY RHAAYTLMLQ EQAPTLKVQG VDLQDYANRL 350
IERYSNPALR HRTWQIAMDG SQKLPQRMLD SVRWHLAHDS KFDLLALGVA 400
GWMRYVGGVD EQGNPIEISD PLLPVIQKAV QSSAEGTARV QSLLAIKAIF 450
GDDLPGNSLF TTKVTEAYLS LLAHGAKATV AKYSVK 486
Length:486
Mass (Da):53,702
Last modified:March 1, 2003 - v1
Checksum:i7D6E149E03B86F80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80428.1.
RefSeqiNP_753863.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80428; AAN80428; c1968.
GeneIDi1035921.
KEGGiecc:c1968.
PATRICi18281837. VBIEscCol75197_1837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80428.1 .
RefSeqi NP_753863.1. NC_004431.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IM7 X-ray 1.90 A 1-486 [» ]
ProteinModelPortali Q8FHD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c1968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80428 ; AAN80428 ; c1968 .
GeneIDi 1035921.
KEGGi ecc:c1968.
PATRICi 18281837. VBIEscCol75197_1837.

Phylogenomic databases

HOGENOMi HOG000202982.
KOi K00540.
OMAi NFFRAHE.
OrthoDBi EOG6X9MNH.

Enzyme and pathway databases

BioCyci ECOL199310:C1968-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
PRINTSi PR00084. MTLDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.
  2. "Crystal structure of fructuronate reductase (ydfI) from E. coli CFT073 (EFI TARGET EFI-506389) complexed with NADH and D-mannonate."
    Wichelecki S., Lukk T., Imker H.J., Nair S.K., Gerlt J.A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH NAD.

Entry informationi

Entry nameiQ8FHD0_ECOL6
AccessioniPrimary (citable) accession number: Q8FHD0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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