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Q8FHC8

- Q8FHC8_ECOL6

UniProt

Q8FHC8 - Q8FHC8_ECOL6

Protein
Submitted name:

Starvation sensing protein rspB

Gene

rspB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cofactori

    Zinc.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451ManganeseImported
    Metal bindingi67 – 671Manganese; via tele nitrogenImported
    Metal bindingi68 – 681ManganeseImported
    Metal bindingi97 – 971ZincImported
    Metal bindingi100 – 1001ZincImported
    Metal bindingi103 – 1031ZincImported
    Metal bindingi111 – 1111ZincImported
    Metal bindingi152 – 1521ManganeseImported
    Binding sitei206 – 2061NADImported
    Binding sitei221 – 2211NADImported
    Binding sitei244 – 2441NADImported
    Binding sitei266 – 2661NAD; via carbonyl oxygenImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi179 – 1802NADImported
    Nucleotide bindingi201 – 2022NADImported
    Nucleotide bindingi290 – 2923NADImported

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. oxidoreductase activity Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    ManganeseImported, Metal-bindingUniRule annotationImported, NADImported, Nucleotide-bindingImported, ZincUniRule annotationImported

    Enzyme and pathway databases

    BioCyciECOL199310:C1970-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Starvation sensing protein rspBImported (EC:1.1.1.-Imported)
    Gene namesi
    Name:rspBImported
    Ordered Locus Names:c1970Imported
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c1970.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4ILKX-ray2.00A/B9-347[»]
    ProteinModelPortaliQ8FHC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000294690.
    KOiK08322.
    OMAiVIDWMEK.
    OrthoDBiEOG6ZWJCC.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FHC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELVRSKVMK SILIEKPNQL SIIEREIPTP SAGEVRVKVK LAGICGSDSH    50
    IYRGHNPFAK YPRVIGHEFF GVIDAVGEGV ESARVGERVA VDPVVSCGHC 100
    YPCSIGKPNV CTTLAVLGVH ADGGFSEYAV VPAKNAWKIP EAVADQYAVM 150
    IEPFTIAANV TGHGQPTEND TVLVYGAGPI GLTIVQVLKG VYNVKNVIVA 200
    DRIDERLEKA KESGADWAIN NSQTPLGESF AEKGIKPTLI IDAACHPSIL 250
    KEAVTLASPA ARIVLMGFSS EPSEVIQQGI TGKELSIFSS RLNANKFPVV 300
    IDWLSKGLIK PEKLITHTFD FQHVADAISL FELDQKHCCK VLLTFSE 347
    Length:347
    Mass (Da):37,452
    Last modified:March 1, 2003 - v1
    Checksum:i233C08AF3C1BF67A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80430.1.
    RefSeqiNP_753865.2. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80430; AAN80430; c1970.
    GeneIDi1035923.
    KEGGiecc:c1970.
    PATRICi18281841. VBIEscCol75197_1839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80430.1 .
    RefSeqi NP_753865.2. NC_004431.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4ILK X-ray 2.00 A/B 9-347 [» ]
    ProteinModelPortali Q8FHC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c1970.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80430 ; AAN80430 ; c1970 .
    GeneIDi 1035923.
    KEGGi ecc:c1970.
    PATRICi 18281841. VBIEscCol75197_1839.

    Phylogenomic databases

    HOGENOMi HOG000294690.
    KOi K08322.
    OMAi VIDWMEK.
    OrthoDBi EOG6ZWJCC.

    Enzyme and pathway databases

    BioCyci ECOL199310:C1970-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPECImported.
    2. "Crystal structure of short chain alcohol dehydrogenase (rspB) from E. coli CFT073 (EFI TARGET EFI-506413) complexed with cofactor NADH."
      Wichelecki S., Lukk T., Imker H.J., Nair S.K., Gerlt J.A.
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 9-347 IN COMPLEX WITH MANGANESE; NAD AND ZINC.

    Entry informationi

    Entry nameiQ8FHC8_ECOL6
    AccessioniPrimary (citable) accession number: Q8FHC8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3