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Q8FHC8 (Q8FHC8_ECOL6) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=1.1.1.- EMBL AAN80430.1
Gene names
Name:rspB EMBL AAN80430.1
Ordered Locus Names:c1970 EMBL AAN80430.1
OrganismEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP] EMBL AAN80430.1
Taxonomic identifier199310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Zinc By similarity. RuleBase RU000467

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding179 – 1802NAD PDB 4ILK
Nucleotide binding201 – 2022NAD PDB 4ILK
Nucleotide binding290 – 2923NAD PDB 4ILK

Sites

Metal binding451Manganese PDB 4ILK
Metal binding671Manganese; via tele nitrogen PDB 4ILK
Metal binding681Manganese PDB 4ILK
Metal binding971Zinc PDB 4ILK
Metal binding1001Zinc PDB 4ILK
Metal binding1031Zinc PDB 4ILK
Metal binding1111Zinc PDB 4ILK
Metal binding1521Manganese PDB 4ILK
Binding site2061NAD PDB 4ILK
Binding site2211NAD PDB 4ILK
Binding site2441NAD PDB 4ILK
Binding site2661NAD; via carbonyl oxygen PDB 4ILK

Sequences

Sequence LengthMass (Da)Tools
Q8FHC8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 233C08AF3C1BF67A

FASTA34737,452
        10         20         30         40         50         60 
MELVRSKVMK SILIEKPNQL SIIEREIPTP SAGEVRVKVK LAGICGSDSH IYRGHNPFAK 

        70         80         90        100        110        120 
YPRVIGHEFF GVIDAVGEGV ESARVGERVA VDPVVSCGHC YPCSIGKPNV CTTLAVLGVH 

       130        140        150        160        170        180 
ADGGFSEYAV VPAKNAWKIP EAVADQYAVM IEPFTIAANV TGHGQPTEND TVLVYGAGPI 

       190        200        210        220        230        240 
GLTIVQVLKG VYNVKNVIVA DRIDERLEKA KESGADWAIN NSQTPLGESF AEKGIKPTLI 

       250        260        270        280        290        300 
IDAACHPSIL KEAVTLASPA ARIVLMGFSS EPSEVIQQGI TGKELSIFSS RLNANKFPVV 

       310        320        330        340 
IDWLSKGLIK PEKLITHTFD FQHVADAISL FELDQKHCCK VLLTFSE 

« Hide

References

« Hide 'large scale' references
[1]"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli."
Welch R.A., Burland V., Plunkett G.III., Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L., Donnenberg M.S., Blattner F.R.
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFT073 / ATCC 700928 / UPEC.
[2]"Crystal structure of short chain alcohol dehydrogenase (rspB) from E. coli CFT073 (EFI TARGET EFI-506413) complexed with cofactor NADH."
Wichelecki S., Lukk T., Imker H.J., Nair S.K., Gerlt J.A.
Submitted (DEC-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 9-347 IN COMPLEX WITH MANGANESE; NAD AND ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014075 Genomic DNA. Translation: AAN80430.1.
RefSeqNP_753865.2. NC_004431.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4ILKX-ray2.00A/B9-347[»]
ProteinModelPortalQ8FHC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING199310.c1970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN80430; AAN80430; c1970.
GeneID1035923.
KEGGecc:c1970.
PATRIC18281841. VBIEscCol75197_1839.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000294690.
KOK08322.
OMAVIDWMEK.
OrthoDBEOG6ZWJCC.

Enzyme and pathway databases

BioCycECOL199310:C1970-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8FHC8_ECOL6
AccessionPrimary (citable) accession number: Q8FHC8
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)