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Q8FHC8

- Q8FHC8_ECOL6

UniProt

Q8FHC8 - Q8FHC8_ECOL6

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Protein
Submitted name:

Starvation sensing protein rspB

Gene

rspB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Note: Zinc.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451ManganeseImported
Metal bindingi67 – 671Manganese; via tele nitrogenImported
Metal bindingi68 – 681ManganeseImported
Metal bindingi97 – 971ZincImported
Metal bindingi100 – 1001ZincImported
Metal bindingi103 – 1031ZincImported
Metal bindingi111 – 1111ZincImported
Metal bindingi152 – 1521ManganeseImported
Binding sitei206 – 2061NADImported
Binding sitei221 – 2211NADImported
Binding sitei244 – 2441NADImported
Binding sitei266 – 2661NAD; via carbonyl oxygenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1802NADImported
Nucleotide bindingi201 – 2022NADImported
Nucleotide bindingi290 – 2923NADImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

ManganeseImported, Metal-bindingUniRule annotationImported, NADImported, Nucleotide-bindingImported, ZincUniRule annotationImported

Enzyme and pathway databases

BioCyciECOL199310:C1970-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Starvation sensing protein rspBImported (EC:1.1.1.-Imported)
Gene namesi
Name:rspBImported
Ordered Locus Names:c1970Imported
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi199310.c1970.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ILKX-ray2.00A/B9-347[»]
ProteinModelPortaliQ8FHC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000294690.
KOiK08322.
OMAiVIDWMEK.
OrthoDBiEOG6ZWJCC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FHC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELVRSKVMK SILIEKPNQL SIIEREIPTP SAGEVRVKVK LAGICGSDSH
60 70 80 90 100
IYRGHNPFAK YPRVIGHEFF GVIDAVGEGV ESARVGERVA VDPVVSCGHC
110 120 130 140 150
YPCSIGKPNV CTTLAVLGVH ADGGFSEYAV VPAKNAWKIP EAVADQYAVM
160 170 180 190 200
IEPFTIAANV TGHGQPTEND TVLVYGAGPI GLTIVQVLKG VYNVKNVIVA
210 220 230 240 250
DRIDERLEKA KESGADWAIN NSQTPLGESF AEKGIKPTLI IDAACHPSIL
260 270 280 290 300
KEAVTLASPA ARIVLMGFSS EPSEVIQQGI TGKELSIFSS RLNANKFPVV
310 320 330 340
IDWLSKGLIK PEKLITHTFD FQHVADAISL FELDQKHCCK VLLTFSE
Length:347
Mass (Da):37,452
Last modified:March 1, 2003 - v1
Checksum:i233C08AF3C1BF67A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN80430.1.
RefSeqiNP_753865.2. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80430; AAN80430; c1970.
GeneIDi1035923.
KEGGiecc:c1970.
PATRICi18281841. VBIEscCol75197_1839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN80430.1 .
RefSeqi NP_753865.2. NC_004431.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4ILK X-ray 2.00 A/B 9-347 [» ]
ProteinModelPortali Q8FHC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c1970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80430 ; AAN80430 ; c1970 .
GeneIDi 1035923.
KEGGi ecc:c1970.
PATRICi 18281841. VBIEscCol75197_1839.

Phylogenomic databases

HOGENOMi HOG000294690.
KOi K08322.
OMAi VIDWMEK.
OrthoDBi EOG6ZWJCC.

Enzyme and pathway databases

BioCyci ECOL199310:C1970-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPECImported.
  2. "Crystal structure of short chain alcohol dehydrogenase (rspB) from E. coli CFT073 (EFI TARGET EFI-506413) complexed with cofactor NADH."
    Wichelecki S., Lukk T., Imker H.J., Nair S.K., Gerlt J.A.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 9-347 IN COMPLEX WITH MANGANESE; NAD AND ZINC.

Entry informationi

Entry nameiQ8FHC8_ECOL6
AccessioniPrimary (citable) accession number: Q8FHC8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3