Reviewed, UniProtKB/Swiss-Prot Q8FH99 (ADD_ECOL6)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	c2015

Organism

Escherichia coli O6 [Complete proteome] [HAMAP]

Taxonomic identifier

217992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Adenosine deaminase HAMAP MF_00540		PRO_0000194368
Sites
	Active site	197	1	Potential
	Active site	245	1	Potential
	Active site	278	1	Potential
	Active site	279	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8FH99-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A89FCBC00F5D3F47	FASTA	333	36,360
	10 20 30 40 50 60 MIDTTLPLTD IHRHLDGNIR PQTILELGRQ YNISLPAQSL ETLIPHVQVI ANEPDLVSFL 70 80 90 100 110 120 TKLDWGVKVL ASLDACRRVA FENIEDAARN GLHYVELRFS PGYMAMAHQL PVAGVVEAVI 130 140 150 160 170 180 DGVREGCRTF GVQAKLIGIM SRTFGEAACQ QELEAFLAHR DQITALDLAG DELGFPGSLF 190 200 210 220 230 240 LSHFNRARDA GWHITVHAGE AAGPESIWQA IRELGAERIG HGVKAIEDRA LMDFLAEQQI 250 260 270 280 290 300 GIESCLTSNI QTSTVADLAA HPLKTFLEHG IRASINTDDP GVQGVDIIHE YTVAAPAAGL 310 320 330 SREQIRQAQI NGLEMAFLSA EEKRALREKV AAK

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014075 Genomic DNA. Translation: AAN80475.1.
RefSeq	NP_753910.1.
3D structure databases
HSSP	HSSP built from PDB template 1A4M based on UniProtKB P03958.
ModBase	Search...
Genome annotation databases
GeneID	1036085.
GenomeReviews	Gene locus c2015 in contig AE014075_GR.
KEGG	ecc:c2015.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8FH99.
OMA	FLKKLDW.
Enzyme and pathway databases
BRENDA	3.5.4.4. 292881.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_ECOL6

Accession

Primary (citable) accession number: Q8FH99

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)