Q8FH03 (ASTE_ECOL6) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Succinylglutamate desuccinylase EC=3.5.1.96 | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O6 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 217992 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 322 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Transforms N(2)-succinylglutamate into succinate and glutamate By similarity. HAMAP MF_00767 |
| Catalytic activity | N-succinyl-L-glutamate + H2O = succinate + L-glutamate. HAMAP MF_00767 |
| Cofactor | Binds 1 zinc ion per subunit By similarity. HAMAP MF_00767 |
| Pathway | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5. HAMAP MF_00767 |
| Sequence similarities | Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Arginine metabolism |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | arginine catabolic process to glutamate Inferred from electronic annotation. Source: InterPro |
| Molecular function | hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro succinylglutamate desuccinylase activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 322 | 322 | Succinylglutamate desuccinylase HAMAP MF_00767 | PRO_0000174641 | |||||
Sites | |||||||||
| Active site | 210 | 1 | Potential | ||||||
| Metal binding | 53 | 1 | Zinc By similarity | ||||||
| Metal binding | 56 | 1 | Zinc By similarity | ||||||
| Metal binding | 147 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014075 Genomic DNA. Translation: AAN80603.1. |
| RefSeq | NP_754038.1. NC_004431.1. |
3D structure databases | |
| ProteinModelPortal | Q8FH03. |
| SMR | Q8FH03. Positions 1-322. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000040901; EBESCP00000039250; EBESCG00000039951. |
| GeneID | 1036569. |
| GenomeReviews | Gene locus c2144 in contig AE014075_GR. |
| KEGG | ecc:c2144. |
| PATRIC | 18282183. VBIEscCol75197_2008. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000010709. |
| HOGENOM | HBG298271. |
| OMA | RWRWLGH. |
| ProtClustDB | PRK05324. |
Family and domain databases | |
| HAMAP | MF_00767. Arg_catab_AstE. [Tree] |
| InterPro | IPR007036. Aste_AspA. IPR016681. SuccinylGlu_desuccinylase. [Graphical view] |
| KO | K05526. |
| Pfam | PF04952. AstE_AspA. 1 hit. [Graphical view] |
| PIRSF | PIRSF017020. AstE. 1 hit. |
| TIGRFAMs | TIGR03242. Arg_catab_astE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ASTE_ECOL6 | ||||||||
| Accession | Primary (citable) accession number: Q8FH03 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with