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Q8FGC8

- Q8FGC8_ECOL6

UniProt

Q8FGC8 - Q8FGC8_ECOL6

Protein

Beta-lactamase

Gene

c2452

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei184 – 1841Phosphate 1Imported
    Binding sitei316 – 3161Phosphate 2Imported

    GO - Molecular functioni

    1. beta-lactamase activity Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Antibiotic resistanceUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL199310:C2452-MONOMER.

    Protein family/group databases

    MEROPSiS12.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
    Gene namesi
    Ordered Locus Names:c2452Imported
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c2452.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E6WX-ray2.19A/B/C41-375[»]
    4E6XX-ray2.24A/B/C41-376[»]
    ProteinModelPortaliQ8FGC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni307 – 3093Phosphate 1 bindingImported

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000009875.
    OMAiHYGKGWR.
    OrthoDBiEOG6F2984.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FGC8-1 [UniParc]FASTAAdd to Basket

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    MTIMEHVSIK TLYHLLCCML LFISAMCALA QEHEPIGAQD ERLSTLIHQR    50
    MQEAKVPALS VSVTIKGVRQ RFVYGVADVA SQKANTLDTV YELGSMSKAF 100
    TGLVVQILIQ EGRLRQGDDI ITYLPEMRLN YQGKPASLTV ADFLYHTSGL 150
    PFSTLARLEN PMPGSAVAQQ LRNENLLFAP GAKFSYASAN YDVLGAVIEN 200
    VTGKTFTEVI AERLTQPLGM SATVAVKGDE IIVNKASGYK LGFGKPVLFH 250
    APLARNHVPA AYIHSTLPDM EIWIDAWLHR KALPATLREA MSNSWRGNSD 300
    VPLAADNRIL YASGWFIDQN QGPYISHGGQ NPNFSSCIAL RPDQQIGIVA 350
    LANMNSNLIL QLCADIDNYL RIGKYADGAG DAITATDTLF VYLTLLLCFW 400
    GAVVVVRGAF RVYRATAHGP GKQQRLRLRV RDYIIALAVP GLVAAMLYVA 450
    PGILSPGLDW RFILVWGPSS VLAIPFGIIL LAFVLTLNHQ IKRILLHNKE 500
    WDDE 504
    Length:504
    Mass (Da):55,472
    Last modified:March 1, 2003 - v1
    Checksum:iA262745585F1E436
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80911.1.
    RefSeqiNP_754344.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80911; AAN80911; c2452.
    GeneIDi1037636.
    KEGGiecc:c2452.
    PATRICi18282790. VBIEscCol75197_2303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80911.1 .
    RefSeqi NP_754344.1. NC_004431.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E6W X-ray 2.19 A/B/C 41-375 [» ]
    4E6X X-ray 2.24 A/B/C 41-376 [» ]
    ProteinModelPortali Q8FGC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c2452.

    Protein family/group databases

    MEROPSi S12.010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80911 ; AAN80911 ; c2452 .
    GeneIDi 1037636.
    KEGGi ecc:c2452.
    PATRICi 18282790. VBIEscCol75197_2303.

    Phylogenomic databases

    HOGENOMi HOG000009875.
    OMAi HYGKGWR.
    OrthoDBi EOG6F2984.

    Enzyme and pathway databases

    BioCyci ECOL199310:C2452-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPECImported.
    2. "The NRP peptidase ClbP as a target for the inhibition of genotoxicity, cell proliferation and tumorogenesismediated by pks-harboring bacteria."
      Cougnoux A., Delmas J., Dalmasso G., Romagnoli C., Cuevas-Ramos G., Oswald E., Parti F., Bonnet R.
      Submitted (MAR-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 41-375.
    3. "The NRP peptidase ClbP as a target for the inhibition of genotoxicity, cell proliferation and tumorogenesismediated by pks-harboring bacteria."
      Cougnoux A., Delmas J., Dalmasso G., Romagnoli C., Cuevas-Ramos G., Oswald E., Prati F., Bonnet R.
      Submitted (MAR-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 41-376.

    Entry informationi

    Entry nameiQ8FGC8_ECOL6
    AccessioniPrimary (citable) accession number: Q8FGC8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3