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Q8FGC8

- Q8FGC8_ECOL6

UniProt

Q8FGC8 - Q8FGC8_ECOL6

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Protein
Beta-lactamase
Gene
c2452
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei184 – 1841Phosphate 1Imported
Binding sitei316 – 3161Phosphate 2Imported

GO - Molecular functioni

  1. beta-lactamase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotation

Enzyme and pathway databases

BioCyciECOL199310:C2452-MONOMER.

Protein family/group databases

MEROPSiS12.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Ordered Locus Names:c2452Imported
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)Imported
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi199310.c2452.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E6WX-ray2.19A/B/C41-375[»]
4E6XX-ray2.24A/B/C41-376[»]
ProteinModelPortaliQ8FGC8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni307 – 3093Phosphate 1 bindingImported

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009875.
OMAiHYGKGWR.
OrthoDBiEOG6F2984.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FGC8-1 [UniParc]FASTAAdd to Basket

« Hide

MTIMEHVSIK TLYHLLCCML LFISAMCALA QEHEPIGAQD ERLSTLIHQR    50
MQEAKVPALS VSVTIKGVRQ RFVYGVADVA SQKANTLDTV YELGSMSKAF 100
TGLVVQILIQ EGRLRQGDDI ITYLPEMRLN YQGKPASLTV ADFLYHTSGL 150
PFSTLARLEN PMPGSAVAQQ LRNENLLFAP GAKFSYASAN YDVLGAVIEN 200
VTGKTFTEVI AERLTQPLGM SATVAVKGDE IIVNKASGYK LGFGKPVLFH 250
APLARNHVPA AYIHSTLPDM EIWIDAWLHR KALPATLREA MSNSWRGNSD 300
VPLAADNRIL YASGWFIDQN QGPYISHGGQ NPNFSSCIAL RPDQQIGIVA 350
LANMNSNLIL QLCADIDNYL RIGKYADGAG DAITATDTLF VYLTLLLCFW 400
GAVVVVRGAF RVYRATAHGP GKQQRLRLRV RDYIIALAVP GLVAAMLYVA 450
PGILSPGLDW RFILVWGPSS VLAIPFGIIL LAFVLTLNHQ IKRILLHNKE 500
WDDE 504
Length:504
Mass (Da):55,472
Last modified:March 1, 2003 - v1
Checksum:iA262745585F1E436
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80911.1.
RefSeqiNP_754344.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80911; AAN80911; c2452.
GeneIDi1037636.
KEGGiecc:c2452.
PATRICi18282790. VBIEscCol75197_2303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80911.1 .
RefSeqi NP_754344.1. NC_004431.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E6W X-ray 2.19 A/B/C 41-375 [» ]
4E6X X-ray 2.24 A/B/C 41-376 [» ]
ProteinModelPortali Q8FGC8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 199310.c2452.

Protein family/group databases

MEROPSi S12.010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80911 ; AAN80911 ; c2452 .
GeneIDi 1037636.
KEGGi ecc:c2452.
PATRICi 18282790. VBIEscCol75197_2303.

Phylogenomic databases

HOGENOMi HOG000009875.
OMAi HYGKGWR.
OrthoDBi EOG6F2984.

Enzyme and pathway databases

BioCyci ECOL199310:C2452-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.
  2. "The NRP peptidase ClbP as a target for the inhibition of genotoxicity, cell proliferation and tumorogenesismediated by pks-harboring bacteria."
    Cougnoux A., Delmas J., Dalmasso G., Romagnoli C., Cuevas-Ramos G., Oswald E., Parti F., Bonnet R.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 41-375 IN COMPLEX WITH PHOSPHATE.
  3. "The NRP peptidase ClbP as a target for the inhibition of genotoxicity, cell proliferation and tumorogenesismediated by pks-harboring bacteria."
    Cougnoux A., Delmas J., Dalmasso G., Romagnoli C., Cuevas-Ramos G., Oswald E., Prati F., Bonnet R.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 41-376 IN COMPLEX WITH PHOSPHATE.

Entry informationi

Entry nameiQ8FGC8_ECOL6
AccessioniPrimary (citable) accession number: Q8FGC8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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