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Protein

S-formylglutathione hydrolase YeiG

Gene

yeiG

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).By similarity

Catalytic activityi

S-formylglutathione + H2O = glutathione + formate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451Charge relay systemBy similarity
Active sitei223 – 2231Charge relay systemBy similarity
Active sitei256 – 2561Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciECOL199310:C2689-MONOMER.

Protein family/group databases

ESTHERiecoli-yeiG. A85-EsteraseD-FGH.

Names & Taxonomyi

Protein namesi
Recommended name:
S-formylglutathione hydrolase YeiG (EC:3.1.2.12)
Short name:
FGH
Gene namesi
Name:yeiG
Ordered Locus Names:c2689
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278S-formylglutathione hydrolase YeiGPRO_0000341672Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi199310.c2689.

Structurei

3D structure databases

ProteinModelPortaliQ8FFU3.
SMRiQ8FFU3. Positions 1-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the esterase D family.Curated

Phylogenomic databases

eggNOGiENOG4105C4W. Bacteria.
COG0627. LUCA.
HOGENOMiHOG000263929.
KOiK01070.
OMAiSVELKCK.
OrthoDBiEOG63587Z.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000801. Esterase_put.
IPR014186. S-formylglutathione_hydrol.
[Graphical view]
PANTHERiPTHR10061. PTHR10061. 1 hit.
PfamiPF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02821. fghA_ester_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FFU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLEEHRCF EGWQQRWRHD SSTLNCPMTF SIFLPPPRDH TPPPVLYWLS
60 70 80 90 100
GLTCNDENFT TKAGAQRVAA ELGIVLVMPD TSPRGEQVAN DDGYDLGQGA
110 120 130 140 150
GFYLNATQPP WATHYRMYDY LRDELPALVQ SQFNVSDRCA ISGHSMGGHG
160 170 180 190 200
ALIMALKNPG KYTSVSAFAP IVNPCSVPWG IKAFSTYLGE DKNAWLEWDS
210 220 230 240 250
CALMYASNAQ DAIPTLIDQG DNDQFLADQL QPAVLAEAAR QKAWPMTLRI
260 270
QPGYDHSYYF IASFIEDHLR FHAQYLLK
Length:278
Mass (Da):31,273
Last modified:March 1, 2003 - v1
Checksum:iBBD4713202782CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81145.1.
RefSeqiWP_000425463.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN81145; AAN81145; c2689.
KEGGiecc:c2689.
PATRICi18283242. VBIEscCol75197_2529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81145.1.
RefSeqiWP_000425463.1. NC_004431.1.

3D structure databases

ProteinModelPortaliQ8FFU3.
SMRiQ8FFU3. Positions 1-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c2689.

Protein family/group databases

ESTHERiecoli-yeiG. A85-EsteraseD-FGH.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN81145; AAN81145; c2689.
KEGGiecc:c2689.
PATRICi18283242. VBIEscCol75197_2529.

Phylogenomic databases

eggNOGiENOG4105C4W. Bacteria.
COG0627. LUCA.
HOGENOMiHOG000263929.
KOiK01070.
OMAiSVELKCK.
OrthoDBiEOG63587Z.

Enzyme and pathway databases

BioCyciECOL199310:C2689-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000801. Esterase_put.
IPR014186. S-formylglutathione_hydrol.
[Graphical view]
PANTHERiPTHR10061. PTHR10061. 1 hit.
PfamiPF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02821. fghA_ester_D. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiSFGH2_ECOL6
AccessioniPrimary (citable) accession number: Q8FFU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.