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Protein

Chaperone protein HscA

Gene

hscA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HscAUniRule annotation
Alternative name(s):
Hsc66UniRule annotation
Gene namesi
Name:hscAUniRule annotation
Ordered Locus Names:c3051
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Chaperone protein HscAPRO_0000078627Add
BLAST

Proteomic databases

PRIDEiQ8FF44.

Interactioni

Protein-protein interaction databases

STRINGi199310.c3051.

Structurei

3D structure databases

ProteinModelPortaliQ8FF44.
SMRiQ8FF44. Positions 20-615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9I. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04044.
OMAiLRGIPAM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR01991. HscA. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FF44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLQISEPG LSAAPHQRRL AAGIDLGTTN SLVATVRSGQ AETLADHEGR
60 70 80 90 100
HLLPSVVHYQ QQGHSVGYDA RTNAALDTAN TISSVKRLMG RSLADIQQRY
110 120 130 140 150
PHLPYQFQAS ENGLPMIETA AGLLNPVRVS ADILKALAAR ATEALAGELD
160 170 180 190 200
GVVITVPAYF DDAQRQGTKD AARLAGLHVL RLLNEPTAAA IAYGLDSGQE
210 220 230 240 250
GVIAVYDLGG GTFDISILRL SRGVFEVLAT GGDSALGGDD FDHLLADYIR
260 270 280 290 300
EQAGIPDRSD NRVQRELLDA AIAAKIALSD ADSVTVNVAG WQGEISREQF
310 320 330 340 350
NELIAPLVKR TLLACRRALK DAGVEADEVL EVVVVGGSTR VPLVRERVGE
360 370 380 390 400
FFGRPPLTSI DPDKVVAIGA AIQADILVGN KPDSEMLLLD VIPLSLGLET
410 420 430 440 450
MGGLVEKVIP RNTTIPVARA QDFTTFKDGQ TAMSIHVMQG ERELVQDCRS
460 470 480 490 500
LARFALRGIP ALPAGGAHIR VTFQVDADGL LSVTAMEKST GVEASIQVKP
510 520 530 540 550
SYGLTDSEIA SMIKDSMSYA EQDVKARMLA EQKVEAARVL ESLHGALAAD
560 570 580 590 600
AALLSAAERQ AIDDAAAHLS EVAQGDDVDA IEQAIKNVDK QTQDFAARRM
610
DQSVRRALKG HSVDEV
Length:616
Mass (Da):65,592
Last modified:July 19, 2003 - v2
Checksum:i2C17F724063AA4F4
GO

Sequence cautioni

The sequence AAN81501 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81501.1. Different initiation.
RefSeqiWP_001196622.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN81501; AAN81501; c3051.
KEGGiecc:c3051.
PATRICi18283958. VBIEscCol75197_2879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81501.1. Different initiation.
RefSeqiWP_001196622.1. NC_004431.1.

3D structure databases

ProteinModelPortaliQ8FF44.
SMRiQ8FF44. Positions 20-615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c3051.

Proteomic databases

PRIDEiQ8FF44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN81501; AAN81501; c3051.
KEGGiecc:c3051.
PATRICi18283958. VBIEscCol75197_2879.

Phylogenomic databases

eggNOGiENOG4105C9I. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04044.
OMAiLRGIPAM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR01991. HscA. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSCA_ECOL6
AccessioniPrimary (citable) accession number: Q8FF44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: September 7, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.