Q8FEF0 (FUCA_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fuculose phosphate aldolase
EC=4.1.2.17

Alternative name(s):
L-fuculose-1-phosphate aldolase

Gene names

Name:	fucA
Ordered Locus Names:	c3368

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

199310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the aldolase class II family. AraD/FucA subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fucose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	L-fuculose-phosphate aldolase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	L-fuculose phosphate aldolase		PRO_0000162927
Sites
	Active site	73	1	Proton acceptor By similarity
	Active site	113	1	Proton donor By similarity
	Metal binding	73	1	Zinc By similarity
	Metal binding	92	1	Zinc By similarity
	Metal binding	94	1	Zinc By similarity
	Metal binding	155	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FEF0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B0394EC5A9574B67	FASTA	215	23,757
	10 20 30 40 50 60 MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL TESHIVFIDG 70 80 90 100 110 120 NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA VSILNRPIPA IHYMIAAAGG 130 140 150 160 170 180 NSIPCAPYAT FGTRELSEHV ALALKNRKAT LLQHHGLIAC EANLEKALWL AHEVEVLAQL 190 200 210 YLTTLAITDP VPVLSDEEIA VVLEKFKTYG LRIEE

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN81815.1.
RefSeq	NP_755245.1. NC_004431.1.
3D structure databases
ProteinModelPortal	Q8FEF0.
SMR	Q8FEF0. Positions 1-210.
ModBase	Search...
Protein-protein interaction databases
STRING	199310.c3368.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN81815; AAN81815; c3368.
GeneID	1039216.
KEGG	ecc:c3368.
PATRIC	18284564. VBIEscCol75197_3171.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000218184.
KO	K01628.
OMA	HYMIAAF.
ProtClustDB	PRK08087.
Enzyme and pathway databases
UniPathway	UPA00563; UER00626.
Family and domain databases
Gene3D	3.40.225.10. 1 hit.
InterPro	IPR001303. Aldolase_II/adducin_N. IPR004782. FucA. [Graphical view]
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
TIGRFAMs	TIGR01086. fucA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCA_ECOL6

Accession

Primary (citable) accession number: Q8FEF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program