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Q8FEF0

- FUCA_ECOL6

UniProt

Q8FEF0 - FUCA_ECOL6

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Protein

L-fuculose phosphate aldolase

Gene
fucA, c3368
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde By similarity.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptor By similarity
Metal bindingi73 – 731Zinc By similarity
Metal bindingi92 – 921Zinc By similarity
Metal bindingi94 – 941Zinc By similarity
Active sitei113 – 1131Proton donor By similarity
Metal bindingi155 – 1551Zinc By similarity

GO - Molecular functioni

  1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fucose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL199310:C3368-MONOMER.
UniPathwayiUPA00563; UER00626.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolase (EC:4.1.2.17)
Alternative name(s):
L-fuculose-1-phosphate aldolase
Gene namesi
Name:fucA
Ordered Locus Names:c3368
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215L-fuculose phosphate aldolaseUniRule annotationPRO_0000162927Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi199310.c3368.

Structurei

3D structure databases

ProteinModelPortaliQ8FEF0.
SMRiQ8FEF0. Positions 1-210.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000218184.
KOiK01628.
OMAiIDACISM.
OrthoDBiEOG6HQSSQ.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
HAMAPiMF_00987. FucA.
InterProiIPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
TIGRFAMsiTIGR01086. fucA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FEF0-1 [UniParc]FASTAAdd to Basket

« Hide

MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL    50
TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA 100
VSILNRPIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT 150
LLQHHGLIAC EANLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA 200
VVLEKFKTYG LRIEE 215
Length:215
Mass (Da):23,757
Last modified:March 1, 2003 - v1
Checksum:iB0394EC5A9574B67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN81815.1.
RefSeqiNP_755245.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN81815; AAN81815; c3368.
GeneIDi1039216.
KEGGiecc:c3368.
PATRICi18284564. VBIEscCol75197_3171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN81815.1 .
RefSeqi NP_755245.1. NC_004431.1.

3D structure databases

ProteinModelPortali Q8FEF0.
SMRi Q8FEF0. Positions 1-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c3368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN81815 ; AAN81815 ; c3368 .
GeneIDi 1039216.
KEGGi ecc:c3368.
PATRICi 18284564. VBIEscCol75197_3171.

Phylogenomic databases

HOGENOMi HOG000218184.
KOi K01628.
OMAi IDACISM.
OrthoDBi EOG6HQSSQ.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00626 .
BioCyci ECOL199310:C3368-MONOMER.

Family and domain databases

Gene3Di 3.40.225.10. 1 hit.
HAMAPi MF_00987. FucA.
InterProi IPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view ]
Pfami PF00596. Aldolase_II. 1 hit.
[Graphical view ]
SMARTi SM01007. Aldolase_II. 1 hit.
[Graphical view ]
SUPFAMi SSF53639. SSF53639. 1 hit.
TIGRFAMsi TIGR01086. fucA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiFUCA_ECOL6
AccessioniPrimary (citable) accession number: Q8FEF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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