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Q8FEF0

- FUCA_ECOL6

UniProt

Q8FEF0 - FUCA_ECOL6

Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

    Catalytic activityi

    L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Metal bindingi73 – 731ZincUniRule annotation
    Metal bindingi92 – 921ZincUniRule annotation
    Metal bindingi94 – 941ZincUniRule annotation
    Active sitei113 – 1131Proton donorUniRule annotation
    Metal bindingi155 – 1551ZincUniRule annotation

    GO - Molecular functioni

    1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fucose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciECOL199310:C3368-MONOMER.
    UniPathwayiUPA00563; UER00626.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
    Alternative name(s):
    L-fuculose-1-phosphate aldolaseUniRule annotation
    Gene namesi
    Name:fucAUniRule annotation
    Ordered Locus Names:c3368
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215L-fuculose phosphate aldolasePRO_0000162927Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi199310.c3368.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FEF0.
    SMRiQ8FEF0. Positions 1-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000218184.
    KOiK01628.
    OMAiIDACISM.
    OrthoDBiEOG6HQSSQ.

    Family and domain databases

    Gene3Di3.40.225.10. 1 hit.
    HAMAPiMF_00987. FucA.
    InterProiIPR001303. Aldolase_II/adducin_N.
    IPR004782. FucA.
    [Graphical view]
    PfamiPF00596. Aldolase_II. 1 hit.
    [Graphical view]
    SMARTiSM01007. Aldolase_II. 1 hit.
    [Graphical view]
    SUPFAMiSSF53639. SSF53639. 1 hit.
    TIGRFAMsiTIGR01086. fucA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FEF0-1 [UniParc]FASTAAdd to Basket

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    MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL    50
    TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA 100
    VSILNRPIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT 150
    LLQHHGLIAC EANLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA 200
    VVLEKFKTYG LRIEE 215
    Length:215
    Mass (Da):23,757
    Last modified:March 1, 2003 - v1
    Checksum:iB0394EC5A9574B67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN81815.1.
    RefSeqiNP_755245.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN81815; AAN81815; c3368.
    GeneIDi1039216.
    KEGGiecc:c3368.
    PATRICi18284564. VBIEscCol75197_3171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN81815.1 .
    RefSeqi NP_755245.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali Q8FEF0.
    SMRi Q8FEF0. Positions 1-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c3368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN81815 ; AAN81815 ; c3368 .
    GeneIDi 1039216.
    KEGGi ecc:c3368.
    PATRICi 18284564. VBIEscCol75197_3171.

    Phylogenomic databases

    HOGENOMi HOG000218184.
    KOi K01628.
    OMAi IDACISM.
    OrthoDBi EOG6HQSSQ.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00626 .
    BioCyci ECOL199310:C3368-MONOMER.

    Family and domain databases

    Gene3Di 3.40.225.10. 1 hit.
    HAMAPi MF_00987. FucA.
    InterProi IPR001303. Aldolase_II/adducin_N.
    IPR004782. FucA.
    [Graphical view ]
    Pfami PF00596. Aldolase_II. 1 hit.
    [Graphical view ]
    SMARTi SM01007. Aldolase_II. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53639. SSF53639. 1 hit.
    TIGRFAMsi TIGR01086. fucA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiFUCA_ECOL6
    AccessioniPrimary (citable) accession number: Q8FEF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3