Q8FDG8 (TTDA_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L(+)-tartrate dehydratase subunit alpha
Short name=L-TTD alpha
EC=4.2.1.32

Gene names

Name:	ttdA
Ordered Locus Names:	c3812

Organism

Escherichia coli O6 [Complete proteome] [HAMAP]

Taxonomic identifier

217992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(R,R)-tartrate = oxaloacetate + H2O.
Cofactor	Iron-sulfur By similarity.
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Induction	Induced by tartrate, via ttdR By similarity.
Sequence similarities	Belongs to the class-I fumarase family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L(+)-tartrate dehydratase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	L(+)-tartrate dehydratase subunit alpha		PRO_0000262698
Sites
	Metal binding	71	1	Iron-sulfur By similarity
	Metal binding	190	1	Iron-sulfur By similarity
	Metal binding	277	1	Iron-sulfur By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FDG8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 720CA4CDBA8B6136	FASTA	303	32,706
	10 20 30 40 50 60 MMSESNKQQA VNKLTEIVAN FTAMISTRMP DDVVDKLKQL KDAETSSMGK IIYHTMFDNM 70 80 90 100 110 120 QKAIDLNRPA CQDTGEIMFF VKVGSRFPLL GELQSILKQA VEEATVKAPL RHNAVEIFDE 130 140 150 160 170 180 VNTGKNTGSG VPWVTWDIVP DGDDAEIEVY MAGGGCTLPG RSKVLMPSEG YEGVVKFVFE 190 200 210 220 230 240 NISTLAVNAC PPVLVGVGIA TSVETAAVLS RKAILRPIGS RHPNPKAAEL ELRLEEGLNR 250 260 270 280 290 300 LGIGPQGLTG NSSVMGVHIE SAARHPSTIG VAVSTGCWAH RRGTLRVHAD LTFENLSHTR SAL

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN82257.1.
RefSeq	NP_755683.1. NC_004431.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000043687; EBESCP00000042036; EBESCG00000042737.
GeneID	1039961.
GenomeReviews	Gene locus c3812 in contig AE014075_GR.
KEGG	ecc:c3812.
PATRIC	18285417. VBIEscCol75197_3592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000010386.
HOGENOM	HBG548096.
OMA	ESSARHP.
ProtClustDB	PRK08230.
Family and domain databases
InterPro	IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat. [Graphical view]
KO	K03779.
Pfam	PF05681. Fumerase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00722. TtdA_fumA_fumB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TTDA_ECOL6

Accession

Primary (citable) accession number: Q8FDG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program