Reviewed, UniProtKB/Swiss-Prot Q8FBC8 (CDH_ECOL6)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	c4870

Organism

Escherichia coli O6 [Complete proteome] [HAMAP]

Taxonomic identifier

217992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198574
Regions
	Transmembrane	4 – 24	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8FBC8-1 [UniParc]. Last modified June 6, 2003. Version 2. Checksum: 5819158EDF86AF70	FASTA	251	28,449
	10 20 30 40 50 60 MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE QCLPNQQENQ NPSPCAEVKP 70 80 90 100 110 120 NAGYVVLKDR HGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSQKYGQPVP 130 140 150 160 170 180 DRAVSLAINS RTGRTQNHFH IHISCIRPDV REQLDNNLAN ISSRWLPLPG GLRGHEYLAR 190 200 210 220 230 240 RVTESELVQR SPFMMLAEEV PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE 250 EIQDHQCEIL R

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014075 Genomic DNA. Translation: AAN83298.1. Different initiation.
RefSeq	NP_756724.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1040191.
GenomeReviews	Gene locus c4870 in contig AE014075_GR.
KEGG	ecc:c4870.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8FBC8.
OMA	Q8FBC8. EIQDHEC.
Enzyme and pathway databases
BRENDA	3.6.1.26. 292881.
Family and domain databases
HAMAP	MF_00319. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase_bac. IPR015993. CDP-diacylglyc_Pase_proteobac. [Graphical view]
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
TIGRFAMs	TIGR00672. cdh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_ECOL6

Accession

Primary (citable) accession number: Q8FBC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	June 6, 2003
Last modified:	June 16, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)