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Q8F9Q1

- TRMB_LEPIN

UniProt

Q8F9Q1 - TRMB_LEPIN

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481S-adenosyl-L-methionineUniRule annotation
Binding sitei73 – 731S-adenosyl-L-methionineUniRule annotation
Binding sitei100 – 1001S-adenosyl-L-methionineUniRule annotation
Active sitei123 – 1231By similarity
Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLINT189518:GJBB-127-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:LA_0140
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferasePRO_0000171342Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi189518.LA0140.

Structurei

3D structure databases

ProteinModelPortaliQ8F9Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000040678.
InParanoidiQ8F9Q1.
KOiK03439.
OMAiIVELAMN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F9Q1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQDLEQKLW SIASGIPFSS DYFLQASPIR KLKKENLFSK VFETYFLELG
60 70 80 90 100
SGWGEVAISM ALQRPNTGFI LMEKKFDRIR HTIREIEKHS LDNVKILCVN
110 120 130 140 150
FNWFLEEVFE ENLFSEILLN FPDPWPKKRH HKKRTVNSKF LESLKILLPE
160 170 180 190 200
KGKFYFATDY GPYARKVIRL FRDSKAFSPE KVELKSERNE IPVSHFERKK
210
REEGKRIYYI DRVLVQK
Length:217
Mass (Da):25,913
Last modified:March 1, 2003 - v1
Checksum:i5DDFFCAEBEFAB967
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN47339.1.
RefSeqiNP_710321.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN47339; AAN47339; LA_0140.
GeneIDi1149483.
KEGGilil:LA_0140.
PATRICi22381125. VBILepInt91350_0143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN47339.1 .
RefSeqi NP_710321.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F9Q1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA0140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN47339 ; AAN47339 ; LA_0140 .
GeneIDi 1149483.
KEGGi lil:LA_0140.
PATRICi 22381125. VBILepInt91350_0143.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000040678.
InParanoidi Q8F9Q1.
KOi K03439.
OMAi IVELAMN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LINT189518:GJBB-127-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiTRMB_LEPIN
AccessioniPrimary (citable) accession number: Q8F9Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3