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Q8F937 (GCSP_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:LA_0360
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) [Reference proteome] [HAMAP]
Taxonomic identifier189518 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length964 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 964964Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166917

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8F937 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 629D62D9B17535D7

FASTA964106,320
        10         20         30         40         50         60 
MNSTLQNQTK TNLEKVGTDP LDTFPRRHIG PNLQQTAEML KELGLSSVEE LIDKAVPVGI 

        70         80         90        100        110        120 
RLKKSLDLPK ASTEHKILQN LKGIASQNQV FRSYIGAGYH SCIIPGVIQR NILENPGWYT 

       130        140        150        160        170        180 
AYTPYQAEIS QGRLEALLNF QTMIIDLTGL EISNASLLDE GTAAAEAMFL AYSVRKNETA 

       190        200        210        220        230        240 
KKFFVSELCH PQTIDVVVTR ANPLGIEVQI GNHESIELNE DFFGVLLQYP ATDGKVIDYT 

       250        260        270        280        290        300 
SFIQRSHNVG AISTVAADLL ALTLLKSPGE MGADIAVGSS QRFGLPLGFG GPHAGYFATK 

       310        320        330        340        350        360 
DEFKRSMPGR LIGVSKDSQG NSGLRLSLQT REQHIRRDKA TSNICTAQVL LAVISSMYAI 

       370        380        390        400        410        420 
YHGPEGLKNI ATRIYKFTSI FANVLKNAGF SITNEFFFDT ITIQAGAKVQ EILNRAYSKK 

       430        440        450        460        470        480 
INFREYKDGK IGITLDETVN LEDLKDLLEI FEIKNTDIEK LFVDVSNVPD SFKRKTSYLT 

       490        500        510        520        530        540 
HPVFQSHHTE TKMLRYIRKL ESRDLSLTTS MIPLGSCTMK LNATTEMYPV TWPEFGAIHP 

       550        560        570        580        590        600 
FAPADQTKGY KIIFEQLEKW LCEITGFAGV SLQPNAGSQG EYAGLLAIRR YHESRNESYR 

       610        620        630        640        650        660 
NVCLIPISAH GTNPASAAMA GFQVVVVSCD PNGNVDLEDL KAKAEEHKKD LAALMITYPS 

       670        680        690        700        710        720 
THGVFEESVK EICQIVHSCG GQVYMDGANM NAQVGLTSPG EIGADVCHLN LHKTFCIPHG 

       730        740        750        760        770        780 
GGGPGVGPIG VAKHLVPFLP GHVLVNNATG NEHGAVSAAP WGSASIVLIS WVYIALMGSE 

       790        800        810        820        830        840 
GLTNATRNSI LNANYIAKRL EKVYPVLYKG KNGFVAHECI LDLRPFKKSA GIEVEDVAKR 

       850        860        870        880        890        900 
LIDYGFHAPT MSFPVPGTLM IEPTESESLE ELDRFCEAML LIYQEILDVQ NGTLDKTDNP 

       910        920        930        940        950        960 
LKNSPHTAAM VTSDRWDHLY PRERAAYPAS WLKDHKFWPY VGRVDNVYGD RNLVCSCLPI 


ESYQ 

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References

[1]"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing."
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. expand/collapse author list , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.
Nature 422:888-893(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 56601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010300 Genomic DNA. Translation: AAN47559.1.
RefSeqNP_710541.1. NC_004342.2.

3D structure databases

ProteinModelPortalQ8F937.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING189518.LA0360.

Proteomic databases

PaxDbQ8F937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN47559; AAN47559; LA_0360.
GeneID1149703.
KEGGlil:LA_0360.
PATRIC22381572. VBILepInt91350_0365.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycLINT189518:GJBB-299-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_LEPIN
AccessionPrimary (citable) accession number: Q8F937
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families