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Protein
Submitted name:

SAM-dependent O-methyltransferase

Gene

LA_0415

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741S-adenosyl-L-homocysteineCombined sources
Binding sitei92 – 921S-adenosyl-L-homocysteineCombined sources
Binding sitei121 – 1211S-adenosyl-L-homocysteine; via amide nitrogenCombined sources
Binding sitei163 – 1631S-adenosyl-L-homocysteineCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciLINT189518:GJBB-354-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
SAM-dependent O-methyltransferaseImported
Gene namesi
Ordered Locus Names:LA_0415Imported
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)Imported
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001408 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi189518.LA_0415.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HNKX-ray2.30A/B/C1-231[»]
ProteinModelPortaliQ8F8Y3.
SMRiQ8F8Y3. Positions 3-231.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8F8Y3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 703S-adenosyl-L-homocysteine bindingCombined sources
Regioni154 – 1563S-adenosyl-L-homocysteine bindingCombined sources

Phylogenomic databases

eggNOGiENOG4107ZBN. Bacteria.
COG4122. LUCA.
HOGENOMiHOG000016839.
InParanoidiQ8F8Y3.
OMAiMVPIADG.
OrthoDBiEOG6ZPT3K.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F8Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKNISLTE SLEEYIFRNS VREPDSFLKL RKETGTLAQA NMQISPEEGQ
60 70 80 90 100
FLNILTKISG AKRIIEIGTF TGYSSLCFAS ALPEDGKILC CDVSEEWTNV
110 120 130 140 150
ARKYWKENGL ENKIFLKLGS ALETLQVLID SKSAPSWASD FAFGPSSIDL
160 170 180 190 200
FFLDADKENY PNYYPLILKL LKPGGLLIAD NVLWDGSVAD LSHQEPSTVG
210 220 230
IRKFNELVYN DSLVDVSLVP IADGVSLVRK R
Length:231
Mass (Da):25,764
Last modified:March 1, 2003 - v1
Checksum:i074B873838BE5EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN47614.1.
RefSeqiNP_710596.1. NC_004342.2.
WP_000087781.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN47614; AAN47614; LA_0415.
GeneIDi1149758.
KEGGilil:LA_0415.
PATRICi22381688. VBILepInt91350_0422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN47614.1.
RefSeqiNP_710596.1. NC_004342.2.
WP_000087781.1. NC_004342.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HNKX-ray2.30A/B/C1-231[»]
ProteinModelPortaliQ8F8Y3.
SMRiQ8F8Y3. Positions 3-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA_0415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN47614; AAN47614; LA_0415.
GeneIDi1149758.
KEGGilil:LA_0415.
PATRICi22381688. VBILepInt91350_0422.

Phylogenomic databases

eggNOGiENOG4107ZBN. Bacteria.
COG4122. LUCA.
HOGENOMiHOG000016839.
InParanoidiQ8F8Y3.
OMAiMVPIADG.
OrthoDBiEOG6ZPT3K.

Enzyme and pathway databases

BioCyciLINT189518:GJBB-354-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8F8Y3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601Imported.
  2. "Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans."
    Hou X., Wang Y., Zhou Z., Bao S., Lin Y., Gong W.
    J. Struct. Biol. 159:523-528(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Entry informationi

Entry nameiQ8F8Y3_LEPIN
AccessioniPrimary (citable) accession number: Q8F8Y3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.