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Q8F814

- DAPAT_LEPIN

UniProt

Q8F814 - DAPAT_LEPIN

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Protein
LL-diaminopimelate aminotransferase
Gene
dapL, LA_0776
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogen By similarity
Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partner By similarity
Binding sitei75 – 751Substrate; shared with dimeric partner By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei187 – 1871Pyridoxal phosphate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei215 – 2151Pyridoxal phosphate By similarity
Binding sitei218 – 2181Pyridoxal phosphate By similarity
Binding sitei246 – 2461Pyridoxal phosphate By similarity
Binding sitei248 – 2481Pyridoxal phosphate By similarity
Binding sitei257 – 2571Pyridoxal phosphate By similarity
Binding sitei292 – 2921Substrate; shared with dimeric partner By similarity
Binding sitei388 – 3881Substrate By similarity

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLINT189518:GJBB-629-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase (EC:2.6.1.83)
Short name:
DAP-AT
Short name:
DAP-aminotransferase
Short name:
LL-DAP-aminotransferase
Gene namesi
Name:dapL
Ordered Locus Names:LA_0776
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408LL-diaminopimelate aminotransferaseUniRule annotation
PRO_0000342247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiQ8F814.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA0776.

Structurei

3D structure databases

ProteinModelPortaliQ8F814.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OMAiHAPYVWL.
OrthoDBiEOG6XWV2X.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8F814-1 [UniParc]FASTAAdd to Basket

« Hide

MANINENYLK LKAGYLFPEI SKRVKIYSEK NPSAKIIRLG IGDVTLPIVP    50
SVVDAMVEAS KEMGTVGGFH GYGPEQGYSF LLKSIADHDY GSLGIKIDES 100
EIFVSDGSKC DCGNIQEIFS TDSKIAVADP VYPVYVDTNV MAGRTGEIGP 150
DGRYSNLIYM PATKENGFQP EIPKEKADIV YLCYPNNPTG TVTTKESLKA 200
WVEYAKKNNS IILYDSAYEA FISEPGVPRS IYEVEGAKEV AIEFRSFSKT 250
AGFTGLRCAY IVIPKELKGK TRSGEEVSLN SLWNRRHTTK FNGVSYVTQK 300
GAEACYSPQG KKEIQTSIAY YMANASKIRD GLKKAGYEVF GGVNAPYIWL 350
KTSDNLSSWD FFDKLLNKAQ VVGTPGSGFG PAGEGYFRLS AFGKKEDVEE 400
AIARITSL 408
Length:408
Mass (Da):44,791
Last modified:March 1, 2003 - v1
Checksum:i15387ED314949D2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN47975.1.
RefSeqiNP_710957.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN47975; AAN47975; LA_0776.
GeneIDi1150119.
KEGGilil:LA_0776.
PATRICi22382410. VBILepInt91350_0782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN47975.1 .
RefSeqi NP_710957.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F814.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA0776.

Proteomic databases

PaxDbi Q8F814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN47975 ; AAN47975 ; LA_0776 .
GeneIDi 1150119.
KEGGi lil:LA_0776.
PATRICi 22382410. VBILepInt91350_0782.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223061.
KOi K10206.
OMAi HAPYVWL.
OrthoDBi EOG6XWV2X.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci LINT189518:GJBB-629-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiDAPAT_LEPIN
AccessioniPrimary (citable) accession number: Q8F814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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