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Q8F814

- DAPAT_LEPIN

UniProt

Q8F814 - DAPAT_LEPIN

Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Substrate; via amide nitrogenUniRule annotation
    Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
    Binding sitei75 – 751Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei215 – 2151Pyridoxal phosphateUniRule annotation
    Binding sitei218 – 2181Pyridoxal phosphateUniRule annotation
    Binding sitei246 – 2461Pyridoxal phosphateUniRule annotation
    Binding sitei248 – 2481Pyridoxal phosphateUniRule annotation
    Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
    Binding sitei292 – 2921Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei388 – 3881SubstrateUniRule annotation

    GO - Molecular functioni

    1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLINT189518:GJBB-629-MONOMER.
    UniPathwayiUPA00034; UER00466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
    Short name:
    DAP-ATUniRule annotation
    Short name:
    DAP-aminotransferaseUniRule annotation
    Short name:
    LL-DAP-aminotransferaseUniRule annotation
    Gene namesi
    Name:dapLUniRule annotation
    Ordered Locus Names:LA_0776
    OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
    Taxonomic identifieri189518 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001408: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408LL-diaminopimelate aminotransferasePRO_0000342247Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PaxDbiQ8F814.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi189518.LA0776.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8F814.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223061.
    KOiK10206.
    OMAiHAPYVWL.
    OrthoDBiEOG6XWV2X.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01642. DapL_aminotrans_1.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8F814-1 [UniParc]FASTAAdd to Basket

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    MANINENYLK LKAGYLFPEI SKRVKIYSEK NPSAKIIRLG IGDVTLPIVP    50
    SVVDAMVEAS KEMGTVGGFH GYGPEQGYSF LLKSIADHDY GSLGIKIDES 100
    EIFVSDGSKC DCGNIQEIFS TDSKIAVADP VYPVYVDTNV MAGRTGEIGP 150
    DGRYSNLIYM PATKENGFQP EIPKEKADIV YLCYPNNPTG TVTTKESLKA 200
    WVEYAKKNNS IILYDSAYEA FISEPGVPRS IYEVEGAKEV AIEFRSFSKT 250
    AGFTGLRCAY IVIPKELKGK TRSGEEVSLN SLWNRRHTTK FNGVSYVTQK 300
    GAEACYSPQG KKEIQTSIAY YMANASKIRD GLKKAGYEVF GGVNAPYIWL 350
    KTSDNLSSWD FFDKLLNKAQ VVGTPGSGFG PAGEGYFRLS AFGKKEDVEE 400
    AIARITSL 408
    Length:408
    Mass (Da):44,791
    Last modified:March 1, 2003 - v1
    Checksum:i15387ED314949D2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010300 Genomic DNA. Translation: AAN47975.1.
    RefSeqiNP_710957.1. NC_004342.2.

    Genome annotation databases

    EnsemblBacteriaiAAN47975; AAN47975; LA_0776.
    GeneIDi1150119.
    KEGGilil:LA_0776.
    PATRICi22382410. VBILepInt91350_0782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010300 Genomic DNA. Translation: AAN47975.1 .
    RefSeqi NP_710957.1. NC_004342.2.

    3D structure databases

    ProteinModelPortali Q8F814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189518.LA0776.

    Proteomic databases

    PaxDbi Q8F814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN47975 ; AAN47975 ; LA_0776 .
    GeneIDi 1150119.
    KEGGi lil:LA_0776.
    PATRICi 22382410. VBILepInt91350_0782.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223061.
    KOi K10206.
    OMAi HAPYVWL.
    OrthoDBi EOG6XWV2X.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00466 .
    BioCyci LINT189518:GJBB-629-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01642. DapL_aminotrans_1.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 56601.

    Entry informationi

    Entry nameiDAPAT_LEPIN
    AccessioniPrimary (citable) accession number: Q8F814
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3