ID   MSRB_LEPIN              Reviewed;         132 AA.
AC   Q8F7W8;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2003, sequence version 2.
DT   03-MAR-2009, entry version 37.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrB;
DE            EC=1.8.4.12;
DE   AltName: Full=Peptide-methionine (R)-S-oxide reductase;
GN   Name=msrB; OrderedLocusNames=LA_0824;
OS   Leptospira interrogans.
OC   Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=173;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX   MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA   Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA   Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA   Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA   Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA   Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA   Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira
RT   interrogans revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit. The zinc ion is important
CC       for the structural integrity of the protein (By similarity).
CC   -!- SIMILARITY: Belongs to the msrB Met sulfoxide reductase family.
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DR   EMBL; AE010300; AAN48023.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_711005.1; -.
DR   HSSP; P14930; 1L1D.
DR   GeneID; 1150167; -.
DR   GenomeReviews; AE010300_GR; LA_0824.
DR   KEGG; lil:LA0824; -.
DR   HOGENOM; Q8F7W8; -.
DR   BioCyc; LINT189518:LA0824-MON; -.
DR   BRENDA; 1.8.4.12; 258108.
DR   GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase ac...; IEA:EC.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01400; -; 1.
DR   InterPro; IPR002579; Methionine_sulphoxide_MsrB.
DR   Gene3D; G3DSA:2.170.150.20; MsrB; 1.
DR   Pfam; PF01641; SelR; 1.
DR   ProDom; PD004057; DUF25; 1.
DR   TIGRFAMs; TIGR00357; MsrB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; Oxidoreductase; Zinc.
FT   CHAIN         1    132       Peptide methionine sulfoxide reductase
FT                                msrB.
FT                                /FTId=PRO_0000140279.
FT   ACT_SITE    121    121       Nucleophile (By similarity).
FT   METAL        49     49       Zinc (By similarity).
FT   METAL        52     52       Zinc (By similarity).
FT   METAL        98     98       Zinc (By similarity).
FT   METAL       101    101       Zinc (By similarity).
SQ   SEQUENCE   132 AA;  14848 MW;  3B9DA6715CDF55E5 CRC64;
     MMNYEVNKSD EDWKKELTPE QYRILRQKGT EMAFTGALYK NQDKGTYVCA ACGAVLFSSD
     TKYESGSGWP SFYQPVKDGV VDKQKDSSHG MERTEILCSK CGGHLGHVFN DGPRPTGLRY
     CINSASLKFQ KE
//