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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei17SubstrateUniRule annotation1
Binding sitei21SubstrateUniRule annotation1
Active sitei69Proton donor/acceptorUniRule annotation1
Binding sitei96SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciLINT189518:G1GL4-733-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:LA_0909
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001408 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786331 – 148Methylglyoxal synthaseAdd BLAST148

Interactioni

Protein-protein interaction databases

STRINGi189518.LA_0909

Structurei

3D structure databases

ProteinModelPortaliQ8F7N5
SMRiQ8F7N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 148MGS-likeUniRule annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 46Substrate bindingUniRule annotation4
Regioni63 – 64Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
InParanoidiQ8F7N5
KOiK01734
OMAiRACDVHN

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8F7N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEVSVPAIK RIVLIAHDNR KEDLVNWVKT HREILSKHQL YGTGTTGKLI
60 70 80 90 100
SEETELPVYR FLSGPLGGDQ QIGAKIAEGD LDIVIFFWDP LTAQPHDPDV
110 120 130 140
KALLRIAVLY NVPMACNRST ADYMISSPQF TKTYKKILLS YNTKVKKD
Length:148
Mass (Da):16,727
Last modified:March 1, 2003 - v1
Checksum:i2A32477D8EB8774E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA Translation: AAN48108.1
RefSeqiNP_711090.1, NC_004342.2
WP_000665953.1, NC_004342.2

Genome annotation databases

EnsemblBacteriaiAAN48108; AAN48108; LA_0909
GeneIDi1150252
KEGGilil:LA_0909
PATRICifig|189518.3.peg.910

Similar proteinsi

Entry informationi

Entry nameiMGSA_LEPIN
AccessioniPrimary (citable) accession number: Q8F7N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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