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Q8F7J8

- PNP_LEPIN

UniProt

Q8F7J8 - PNP_LEPIN

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861MagnesiumUniRule annotation
Metal bindingi492 – 4921MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciLINT189518:GJBB-767-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:LA_0947
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Polyribonucleotide nucleotidyltransferasePRO_0000329699Add
BLAST

Proteomic databases

PaxDbiQ8F7J8.

Interactioni

Protein-protein interaction databases

STRINGi189518.LA0947.

Structurei

3D structure databases

ProteinModelPortaliQ8F7J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KHUniRule annotationAdd
BLAST
Domaini622 – 69069S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
InParanoidiQ8F7J8.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F7J8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHTISGQYG RDTIVLETGS WAKQAHGAVV YKSGNLVLLA TVCAADEAKE
60 70 80 90 100
GQDFFPLTCE YTEKLYSVGR FPGGYFKREA KPPEHEILIS RIIDRPIRPL
110 120 130 140 150
FPEGYFCEVQ LQVQVLSADG DVSVAGHALN AASAALAVSD IPFNGPIAGA
160 170 180 190 200
RIGRVNGELI LNPTTKEILN SDLDLVVAGT KTHIVMIEGE AKELSNEEMI
210 220 230 240 250
AALRFAQKHI AEFVTLQEEY AKKIGVVKRE VKLKVRDEEL LSKVKEYAFA
260 270 280 290 300
KLTTANQTPD KTARNKEISN VNKEVVEFFK DTIEDSDKIK DIKAYLHELE
310 320 330 340 350
YEIVREQVLT KGTRFDGRKL DEIRSISVEI NPLPGPHGSA VFTRGQTQSL
360 370 380 390 400
GVVTLGTGSD NQRYETLEGQ KEKSFMLHYN FPAFSVGEVR RSSGPGRREI
410 420 430 440 450
GHGNLAERAL KLVLPKPDEF PYVIRVVSEI LESNGSSSMA SVCSGSLALM
460 470 480 490 500
AAGVPIQGSV SGIAMGLFSD SSGKYAVLSD IAGLEDHFGD MDCKIAGTRK
510 520 530 540 550
GITAFQMDLK VTGVSFDVLE SVFEQAQRGR FHILDIMEKH ISKASSTLAG
560 570 580 590 600
TAPRIIVRNI PKDRIGELIG PGGKNVRGIS ELTGAELYIE DDGKVTISGS
610 620 630 640 650
NQESAEKAAK MVDGFFAEVE VGKIYEGKVK RIADFGAFVE ILPGKEGLCH
660 670 680 690
ISKIDFKRVN SVKDIVKEGD IIRVKVLNVD KTGKIDLSRK DALEEEQV
Length:698
Mass (Da):76,296
Last modified:March 1, 2003 - v1
Checksum:iCCB5308216AF90C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48146.1.
RefSeqiNP_711128.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN48146; AAN48146; LA_0947.
GeneIDi1150290.
KEGGilil:LA_0947.
PATRICi22382744. VBILepInt91350_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48146.1 .
RefSeqi NP_711128.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F7J8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA0947.

Proteomic databases

PaxDbi Q8F7J8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN48146 ; AAN48146 ; LA_0947 .
GeneIDi 1150290.
KEGGi lil:LA_0947.
PATRICi 22382744. VBILepInt91350_0949.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
InParanoidi Q8F7J8.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci LINT189518:GJBB-767-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiPNP_LEPIN
AccessioniPrimary (citable) accession number: Q8F7J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3