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Protein

DNA helicase

Gene

LA_0966

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent DNA helicase activity Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. exonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ExonucleaseSAAS annotation, HelicaseSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLINT189518:GJBB-781-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Ordered Locus Names:LA_0966Imported
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)Imported
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi189518.LA0966.

Structurei

3D structure databases

ProteinModelPortaliQ8F7H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains uvrD-like helicase ATP-binding domain.SAAS annotation
Contains uvrD-like helicase C-terminal domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000041061.
InParanoidiQ8F7H9.
KOiK03582.
OMAiINTLANC.
OrthoDBiEOG6677M1.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
3.90.320.10. 1 hit.
HAMAPiMF_01485. RecB.
InterProiIPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR011604. Exonuc_phg/RecB_C.
IPR027417. P-loop_NTPase.
IPR004586. RecB.
IPR011335. Restrct_endonuc-II-like.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 1 hit.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F7H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVSRTYKFK SSFIEASAGT GKTYTIMEIV IDLILEHKIP LTQILILTYT
60 70 80 90 100
EKAAGELKER LRKKLISSGL TKEARELDQV TISTIHGFCN TILKEYPVET
110 120 130 140 150
ETHTNWILTD ALERLNIALY KLQHEEWNSW VDPEKLEDFI LSSKYRFKKE
160 170 180 190 200
NILISASKLL SGKKYKYSNE TTTMTSETFL QKTALIIADM VLKEFKTSEW
210 220 230 240 250
MSYDQMILKT RDSLENPRLR KALQSRYRVG ILDEFQDTDG AQYEIFKRLF
260 270 280 290 300
LESNDDRALY LIGDPKQSIY GFRGADIGIY LQAKEELKKH KAEEISLNVN
310 320 330 340 350
YRSVPELIRA YNEIFGGKSG KQSFFPILEQ SIPIQYEPVF APKENIKVLL
360 370 380 390 400
SDKQKQGPIQ IVRFTGKDFW NTQDAKNAWG QFISEEILKL IHKEDPFTYQ
410 420 430 440 450
VAEGDLYYVE KKLKLREIAV LVKSKSEGKL AEQFLKLRGI PCSFYKQEGI
460 470 480 490 500
YQSAESYQIS NIFECLLDPN KPSSYRKLLL GDLFQIHPAH LPYFDEHSID
510 520 530 540 550
SYEKSILDRW KTLSMDRKFS ELFRSIEEDS RIFLTEDATD IDWERKRTNY
560 570 580 590 600
RQIFRRLLQF QIANQADLEE ILEELKLLQK SFKNEEELPL FEKETEKDAV
610 620 630 640 650
QILTLHASKG LEWPVVFLFN LSGDYIPEVY DYPFVDKDGK LSWKLSLWDN
660 670 680 690 700
EEEKKISKEI YSNQSLNENK RLLYVGITRS KVRIYLPFYT PLNNWKTRDS
710 720 730 740 750
AYYKILYPRL QSILENEIDT DLFHVVSWAP TPFDSTDPKR IDWNLDSEIC
760 770 780 790 800
FTPLLYEEPE TSKTIRLNSY SSLRTSMNFS EEVSLSVLEE KTRIQSDDVE
810 820 830 840 850
NSETVIKDAL PSSASIGSFL HSLLEELDFS IFKTTTSKEL LKNEKIISRM
860 870 880 890 900
DFHLDYFRIL KREEGRPILE KETVQKRTVE ILWNLLNANI LDQKGALFRL
910 920 930 940 950
VDLPKENRVS EMDFYLDLDT NPGNFLRGSI DLVFQIDDKF YLADYKSNLL
960 970 980 990 1000
EDYSTISLKR NVENLESRYD LQRDIYALVL YEYLKNLFGP KEALQKIGGV
1010 1020 1030 1040
YYFFLRGMIY GESSGIYSDF FWSLERIESI RKTVLESTTF RWEKSN
Length:1,046
Mass (Da):122,763
Last modified:March 1, 2003 - v1
Checksum:i642ADEDB7DE67DA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48165.1.
RefSeqiNP_711147.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN48165; AAN48165; LA_0966.
GeneIDi1150309.
KEGGilil:LA_0966.
PATRICi22382783. VBILepInt91350_0968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48165.1.
RefSeqiNP_711147.1. NC_004342.2.

3D structure databases

ProteinModelPortaliQ8F7H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA0966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN48165; AAN48165; LA_0966.
GeneIDi1150309.
KEGGilil:LA_0966.
PATRICi22382783. VBILepInt91350_0968.

Phylogenomic databases

HOGENOMiHOG000041061.
InParanoidiQ8F7H9.
KOiK03582.
OMAiINTLANC.
OrthoDBiEOG6677M1.

Enzyme and pathway databases

BioCyciLINT189518:GJBB-781-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
3.90.320.10. 1 hit.
HAMAPiMF_01485. RecB.
InterProiIPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR011604. Exonuc_phg/RecB_C.
IPR027417. P-loop_NTPase.
IPR004586. RecB.
IPR011335. Restrct_endonuc-II-like.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 1 hit.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601Imported.

Entry informationi

Entry nameiQ8F7H9_LEPIN
AccessioniPrimary (citable) accession number: Q8F7H9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.