ID   Q8F7F2_LEPIN            Unreviewed;       749 AA.
AC   Q8F7F2;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN48192.1};
GN   OrderedLocusNames=LA_0993 {ECO:0000313|EMBL:AAN48192.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN48192.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN48192.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN48192.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010300; AAN48192.1; -; Genomic_DNA.
DR   RefSeq; NP_711174.1; NC_004342.2.
DR   RefSeq; WP_000133844.1; NC_004342.2.
DR   AlphaFoldDB; Q8F7F2; -.
DR   STRING; 189518.LA_0993; -.
DR   PaxDb; 189518-LA_0993; -.
DR   EnsemblBacteria; AAN48192; AAN48192; LA_0993.
DR   KEGG; lil:LA_0993; -.
DR   PATRIC; fig|189518.3.peg.993; -.
DR   HOGENOM; CLU_016487_0_0_12; -.
DR   InParanoid; Q8F7F2; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        170..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          454..506
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          538..670
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   749 AA;  85011 MW;  5DE920EA2B3BE347 CRC64;
     MTEDKTFLFC SRLKEGGMLD RWKDKNDKSV RWEELPNLHS DLQDLDLIIR SLISEKLSLG
     IREIIFCLSA EQALSLKKSR DFLKLIKDLK RAGFTISSAD KDKILSTNVE SSSKFFRYLE
     NRSRNVNCLV WTEDLALSQI ESKYYDFLNH FHGYKFESFR PSRFTIRVKL LSIVSAIITL
     SMGLMITMAT YFFRKYSEIL IQEYNLSLAR MTGIQLSGQL KETTRKIQDF RSEDSEKFFR
     TNSNAVAYVR FKNKTVNSAL EIDSLFWNSK FLKSNSVVPD PTNLKNALEK SFSRLSGTLE
     VLNVSNEFGF PAVAVLLPVG VEISGLVFSA SEFLGSFLSV RQTDFFQMIV VDSSGNLIAH
     SNDKEAVSGK DYKKHPLVEN MLRSPSDNGS QRFDFEGREV LGSYQQLEVG GLGIISTLDA
     DIAFEAVYKI RRQNFWIMIS VLSVAFFVVF VFSRTLTIPI IQLLSATKKV EQGNYAVDIR
     ATTHDEVGVL TNSFLRMARG LEEREKIKNT FGKFVNKEIA ERALSSDLKL GGENREVTVF
     FSDLRNFTGM SEKMKPEEVV EFLNQYFTEM VECIYLTQGI VDKFIGDAVM AHWGALVYDG
     NEAKNSINAA LLMRRALIEF NLKGKEIGRP FTRFGCGINS GPVIVGQIGS EKKLEFTVIG
     DTVNLASRIE YLNKEFGTDI LISESTYQQA KDHFNFVELP PVWIRGKEKP QVVYAVLGWK
     DDQDCPKSLE ELRTLCGIPD PENPSRSLA
//