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Protein
Submitted name:

Adenylate/guanylate cyclase

Gene

cyaA

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron-sulfur cluster binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. peroxidase activity Source: InterPro
  6. phosphorus-oxygen lyase activity Source: InterPro

GO - Biological processi

  1. cyclic nucleotide biosynthetic process Source: InterPro
  2. intracellular signal transduction Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Iron, Iron-sulfurUniRule annotation, Metal-binding

Enzyme and pathway databases

BioCyciLINT189518:GJBB-956-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate/guanylate cyclaseImported
Gene namesi
Name:cyaAImported
Ordered Locus Names:LA_1184Imported
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)Imported
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi189518.LA1184.

Structurei

3D structure databases

ProteinModelPortaliQ8F6W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family.UniRule annotation

Phylogenomic databases

InParanoidiQ8F6W6.
KOiK01768.
OrthoDBiEOG6PZX72.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001054. A/G_cyclase.
IPR002207. Asc_peroxidase.
IPR012675. Beta-grasp_dom.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F6W6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILVNFENEK EISLSKPQNL LEISLNNGIP HTHACGGNAR CSTCRVLVLE
60 70 80 90 100
NPSHLSPPEQ KEKELSQKKG FPKSVRLACQ TTVLGDVRVR RIVLDEEDYN
110 120 130 140 150
LTIPGSATIS GEEKEIAILF SDIRDFTLFS ESHLPYDVIH ILNRYFYKMG
160 170 180 190 200
DVILKHGGKI DKYIGDGLMA LFGVNGGSPQ EICISALRAA KEMELELYSL
210 220 230 240 250
NEYLKSHLHT SFRIGVGVHY GNCILGQLGH PANMSYTAIG DSVNIASRIE
260 270 280 290 300
SKTKKSGASV LISESLYKQV KEKVVKGRVF SAQLKGKTGN YKLYEIQEIL
310 320 330 340 350
EKVDANLWEE AKNSLRRIIL VREVGSWLKL VYHLSCLFDE NQNWIGLSAA
360 370 380 390 400
NSFQKFSKLP ENGDLVQNFY QIKDTFNEQF QNSFSFADLL ALAGAVAIEK
410 420 430 440 450
SGGPKIPIQP GRKDRLLSEV FQILPLSMQT QKDQLPYLQK MKLGIRDIVL
460 470 480 490 500
ISGARTIGWL GGESFTSNPY NFDNSYFHVL LKAGLEGPLL IPNDRELLKN
510 520 530
DESRAFVLDY ALDPSKFFED FTSTYLKLTS
Length:530
Mass (Da):59,459
Last modified:March 1, 2003 - v1
Checksum:iEBE31DDC08E45D10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48383.1.
RefSeqiNP_711365.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN48383; AAN48383; LA_1184.
GeneIDi1150527.
KEGGilil:LA_1184.
PATRICi22383213. VBILepInt91350_1179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48383.1.
RefSeqiNP_711365.1. NC_004342.2.

3D structure databases

ProteinModelPortaliQ8F6W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA1184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN48383; AAN48383; LA_1184.
GeneIDi1150527.
KEGGilil:LA_1184.
PATRICi22383213. VBILepInt91350_1179.

Phylogenomic databases

InParanoidiQ8F6W6.
KOiK01768.
OrthoDBiEOG6PZX72.

Enzyme and pathway databases

BioCyciLINT189518:GJBB-956-MONOMER.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001054. A/G_cyclase.
IPR002207. Asc_peroxidase.
IPR012675. Beta-grasp_dom.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601Imported.

Entry informationi

Entry nameiQ8F6W6_LEPIN
AccessioniPrimary (citable) accession number: Q8F6W6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.