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Q8F6S7

- ODO1_LEPIN

UniProt

Q8F6S7 - ODO1_LEPIN

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
sucA, odhA, LA_1224
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciLINT189518:GJBB-988-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Synonyms:odhA
Ordered Locus Names:LA_1224
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9209202-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_0000162174Add
BLAST

Proteomic databases

PaxDbiQ8F6S7.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA1224.

Structurei

3D structure databases

ProteinModelPortaliQ8F6S7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8F6S7-1 [UniParc]FASTAAdd to Basket

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MKIEKLMALY GENGALLEEL YNQYKLNPET LDKEWKSFFQ EVDTNGLANG    50
SGYTNGNGKS AVATSFTDAQ AASIREMGII NLLNAYRRQG HLAAKLDPLG 100
IQKPNRTFID SKLHNISPAD IDTVVDSETL GRVKLAEIVD LYEKVYCNTI 150
GAEHFYLVND EEREWLQKKM ESPEFLAPLP RGIKLRLFEK LFQADYFETF 200
LAKKYVGKKR FSLEGGESFI PLLDTIVEEA GYHQMDGLVI GMAHRGRLNV 250
LVNIIEKPAS LIFAEFEEKT DKDNLSYADV KYHLGYSNSR MTTSGKEVKL 300
SLAFNPSHLE CVDPVVTGSV RARQTLIGDK DRSKYMPILI HGDAAFAGQG 350
VVAETLNLMN LEGYTTGGTF HIVVNNQIGF TTLPDESRST LYATDLAKGF 400
QIPIIHVNGD DPEAVYRVVK LGMEYRQKFK KDFIIDLVCY RRLGHNETDE 450
PAFTQPKMYA IIKNHPPTVK LYEKRLVEEG DIPQEDIDFI KNGSMHGLED 500
SFQRAKEQDV KIRVDTMQGV WSKFSKDSLD SEPATKLLAE QMHGIVQALT 550
SVPQGFTPNS KLVKLLQSRK EMAEGKIPVD WGFAEALSFG SILESGFRIR 600
LSGQDSQRGT FSHRHAVLVD TNTNEKYIPL NHISSKQAKA EIINSSLSEF 650
SVLGFEYGYS LSDPNALVMW EAQFGDFANS AQVIFDQFIS SSEVKWQRLS 700
GLIMLLPHGY EGQGPEHSSA RLERFLQLCA LDNMQVCNLT TAAQYFHLLR 750
RQMLRNYRKP LVIVTPKSLL RFPASLSPVE DILQGAFREI LIDDSGSKPD 800
KIEKVVFSAG KVYYDLMKYK DENKIKNVAL VRVEQIYPFP AKEIQSSLKT 850
FKNAKQFVWC QEEPKNQGAW FFVRERIEEL LPGNARLVYA GRHESPSPAA 900
GHMKLHLQEQ DQLVLDAFQA 920
Length:920
Mass (Da):103,922
Last modified:March 1, 2003 - v1
Checksum:i8A4513F3F1B3DD0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN48423.1.
RefSeqiNP_711405.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN48423; AAN48423; LA_1224.
GeneIDi1150567.
KEGGilil:LA_1224.
PATRICi22383293. VBILepInt91350_1221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN48423.1 .
RefSeqi NP_711405.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F6S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA1224.

Proteomic databases

PaxDbi Q8F6S7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN48423 ; AAN48423 ; LA_1224 .
GeneIDi 1150567.
KEGGi lil:LA_1224.
PATRICi 22383293. VBILepInt91350_1221.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci LINT189518:GJBB-988-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiODO1_LEPIN
AccessioniPrimary (citable) accession number: Q8F6S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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