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Q8F6S7 (ODO1_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Synonyms:odhA
Ordered Locus Names:LA_1224
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) [Reference proteome] [HAMAP]
Taxonomic identifier189518 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length920 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9209202-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_0000162174

Sequences

Sequence LengthMass (Da)Tools
Q8F6S7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 8A4513F3F1B3DD0A

FASTA920103,922
        10         20         30         40         50         60 
MKIEKLMALY GENGALLEEL YNQYKLNPET LDKEWKSFFQ EVDTNGLANG SGYTNGNGKS 

        70         80         90        100        110        120 
AVATSFTDAQ AASIREMGII NLLNAYRRQG HLAAKLDPLG IQKPNRTFID SKLHNISPAD 

       130        140        150        160        170        180 
IDTVVDSETL GRVKLAEIVD LYEKVYCNTI GAEHFYLVND EEREWLQKKM ESPEFLAPLP 

       190        200        210        220        230        240 
RGIKLRLFEK LFQADYFETF LAKKYVGKKR FSLEGGESFI PLLDTIVEEA GYHQMDGLVI 

       250        260        270        280        290        300 
GMAHRGRLNV LVNIIEKPAS LIFAEFEEKT DKDNLSYADV KYHLGYSNSR MTTSGKEVKL 

       310        320        330        340        350        360 
SLAFNPSHLE CVDPVVTGSV RARQTLIGDK DRSKYMPILI HGDAAFAGQG VVAETLNLMN 

       370        380        390        400        410        420 
LEGYTTGGTF HIVVNNQIGF TTLPDESRST LYATDLAKGF QIPIIHVNGD DPEAVYRVVK 

       430        440        450        460        470        480 
LGMEYRQKFK KDFIIDLVCY RRLGHNETDE PAFTQPKMYA IIKNHPPTVK LYEKRLVEEG 

       490        500        510        520        530        540 
DIPQEDIDFI KNGSMHGLED SFQRAKEQDV KIRVDTMQGV WSKFSKDSLD SEPATKLLAE 

       550        560        570        580        590        600 
QMHGIVQALT SVPQGFTPNS KLVKLLQSRK EMAEGKIPVD WGFAEALSFG SILESGFRIR 

       610        620        630        640        650        660 
LSGQDSQRGT FSHRHAVLVD TNTNEKYIPL NHISSKQAKA EIINSSLSEF SVLGFEYGYS 

       670        680        690        700        710        720 
LSDPNALVMW EAQFGDFANS AQVIFDQFIS SSEVKWQRLS GLIMLLPHGY EGQGPEHSSA 

       730        740        750        760        770        780 
RLERFLQLCA LDNMQVCNLT TAAQYFHLLR RQMLRNYRKP LVIVTPKSLL RFPASLSPVE 

       790        800        810        820        830        840 
DILQGAFREI LIDDSGSKPD KIEKVVFSAG KVYYDLMKYK DENKIKNVAL VRVEQIYPFP 

       850        860        870        880        890        900 
AKEIQSSLKT FKNAKQFVWC QEEPKNQGAW FFVRERIEEL LPGNARLVYA GRHESPSPAA 

       910        920 
GHMKLHLQEQ DQLVLDAFQA 

« Hide

References

[1]"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing."
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. expand/collapse author list , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.
Nature 422:888-893(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 56601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010300 Genomic DNA. Translation: AAN48423.1.
RefSeqNP_711405.1. NC_004342.2.

3D structure databases

ProteinModelPortalQ8F6S7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING189518.LA1224.

Proteomic databases

PaxDbQ8F6S7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN48423; AAN48423; LA_1224.
GeneID1150567.
KEGGlil:LA_1224.
PATRIC22383293. VBILepInt91350_1221.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycLINT189518:GJBB-988-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_LEPIN
AccessionPrimary (citable) accession number: Q8F6S7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families