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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciLINT189518:GJBB-988-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:sucAUniRule annotation
Synonyms:odhAUniRule annotation
Ordered Locus Names:LA_1224
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
ProteomesiUP000001408 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9209202-oxoglutarate dehydrogenase E1 componentPRO_0000162174Add
BLAST

Proteomic databases

PaxDbiQ8F6S7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA_1224.

Structurei

3D structure databases

ProteinModelPortaliQ8F6S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
InParanoidiQ8F6S7.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8F6S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEKLMALY GENGALLEEL YNQYKLNPET LDKEWKSFFQ EVDTNGLANG
60 70 80 90 100
SGYTNGNGKS AVATSFTDAQ AASIREMGII NLLNAYRRQG HLAAKLDPLG
110 120 130 140 150
IQKPNRTFID SKLHNISPAD IDTVVDSETL GRVKLAEIVD LYEKVYCNTI
160 170 180 190 200
GAEHFYLVND EEREWLQKKM ESPEFLAPLP RGIKLRLFEK LFQADYFETF
210 220 230 240 250
LAKKYVGKKR FSLEGGESFI PLLDTIVEEA GYHQMDGLVI GMAHRGRLNV
260 270 280 290 300
LVNIIEKPAS LIFAEFEEKT DKDNLSYADV KYHLGYSNSR MTTSGKEVKL
310 320 330 340 350
SLAFNPSHLE CVDPVVTGSV RARQTLIGDK DRSKYMPILI HGDAAFAGQG
360 370 380 390 400
VVAETLNLMN LEGYTTGGTF HIVVNNQIGF TTLPDESRST LYATDLAKGF
410 420 430 440 450
QIPIIHVNGD DPEAVYRVVK LGMEYRQKFK KDFIIDLVCY RRLGHNETDE
460 470 480 490 500
PAFTQPKMYA IIKNHPPTVK LYEKRLVEEG DIPQEDIDFI KNGSMHGLED
510 520 530 540 550
SFQRAKEQDV KIRVDTMQGV WSKFSKDSLD SEPATKLLAE QMHGIVQALT
560 570 580 590 600
SVPQGFTPNS KLVKLLQSRK EMAEGKIPVD WGFAEALSFG SILESGFRIR
610 620 630 640 650
LSGQDSQRGT FSHRHAVLVD TNTNEKYIPL NHISSKQAKA EIINSSLSEF
660 670 680 690 700
SVLGFEYGYS LSDPNALVMW EAQFGDFANS AQVIFDQFIS SSEVKWQRLS
710 720 730 740 750
GLIMLLPHGY EGQGPEHSSA RLERFLQLCA LDNMQVCNLT TAAQYFHLLR
760 770 780 790 800
RQMLRNYRKP LVIVTPKSLL RFPASLSPVE DILQGAFREI LIDDSGSKPD
810 820 830 840 850
KIEKVVFSAG KVYYDLMKYK DENKIKNVAL VRVEQIYPFP AKEIQSSLKT
860 870 880 890 900
FKNAKQFVWC QEEPKNQGAW FFVRERIEEL LPGNARLVYA GRHESPSPAA
910 920
GHMKLHLQEQ DQLVLDAFQA
Length:920
Mass (Da):103,922
Last modified:March 1, 2003 - v1
Checksum:i8A4513F3F1B3DD0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48423.1.
RefSeqiNP_711405.1. NC_004342.2.
WP_000687652.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN48423; AAN48423; LA_1224.
GeneIDi1150567.
KEGGilil:LA_1224.
PATRICi22383293. VBILepInt91350_1221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48423.1.
RefSeqiNP_711405.1. NC_004342.2.
WP_000687652.1. NC_004342.2.

3D structure databases

ProteinModelPortaliQ8F6S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA_1224.

Proteomic databases

PaxDbiQ8F6S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN48423; AAN48423; LA_1224.
GeneIDi1150567.
KEGGilil:LA_1224.
PATRICi22383293. VBILepInt91350_1221.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
InParanoidiQ8F6S7.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciLINT189518:GJBB-988-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiODO1_LEPIN
AccessioniPrimary (citable) accession number: Q8F6S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.