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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:LA_1688
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001408 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001515711 – 586Arginine--tRNA ligaseAdd BLAST586

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA_1688.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 143"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
HOGENOMiHOG000247214.
InParanoidiQ8F5J3.
KOiK01887.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8F5J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENETLKQI VLKTLEESVN SLISSFPEVE KETFKIKIEY SRDEKFGDYS
60 70 80 90 100
TSFALENSKL LKRNPIQVSK ELVEILQKRT DLFEKVDFTP PGFVNFRIST
110 120 130 140 150
SFLLNYIETS VLSGNYFPKV DLPLKINLEF VSANPTGPLN IVSARAAANG
160 170 180 190 200
DTMASLLKAI GHNVDKEFYI NDYGNQVFLL GVSTLVRIRE LKGEEGTQQE
210 220 230 240 250
TTDDTPIEII LEKNILPAEG YRGEYIKDIA SSLLKDPKKN VTIENLLKQK
260 270 280 290 300
KYKELAELCA VWTIENNLIW QRKDLDAFGV EFDRYFSERT LHEADKVLSV
310 320 330 340 350
MKDLEKSGKI FQEDGKKVFR STEYGDDKDR VVVRDDGRPT YLLADIAYHK
360 370 380 390 400
DKIERGYDKI YDIWGPDHHG YISRLSGAVQ SLGYKKENFK VIISQQVNLL
410 420 430 440 450
ESGQKVKMSK RAGSFQTMSD LIGFLGKHGK DVGRYFFVMR SLDAPLDFDL
460 470 480 490 500
DLAKDESDKN PVFYLQYAHA RICSIFKEVG DQTSKEATAI LEMSEERKRL
510 520 530 540 550
LFWIARFPEE IFDSANAMEP HRVTNYLQSF AKAFTSFYLA KDNRLKDASK
560 570 580
EVRLGLARIC LAAKNVLAEG LKLIGVSAPE RMEKEN
Length:586
Mass (Da):66,934
Last modified:August 10, 2010 - v2
Checksum:i1E1076F05F07E695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN48887.2.
RefSeqiNP_711869.2. NC_004342.2.
WP_000662007.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN48887; AAN48887; LA_1688.
GeneIDi1151031.
KEGGilil:LA_1688.
PATRICifig|189518.3.peg.1681.

Similar proteinsi

Entry informationi

Entry nameiSYR_LEPIN
AccessioniPrimary (citable) accession number: Q8F5J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: August 10, 2010
Last modified: August 30, 2017
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families