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Q8F4Q4

- IMDH_LEPIN

UniProt

Q8F4Q4 - IMDH_LEPIN

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

K(+)UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei267 – 2671NADUniRule annotation
Metal bindingi319 – 3191Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi321 – 3211Potassium; via carbonyl oxygenUniRule annotation
Binding sitei322 – 3221IMPUniRule annotation
Active sitei324 – 3241Thioimidate intermediateUniRule annotation
Metal bindingi324 – 3241Potassium; via carbonyl oxygenUniRule annotation
Binding sitei432 – 4321IMPUniRule annotation
Metal bindingi492 – 4921Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 3193NADUniRule annotation

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciLINT189518:GJBB-1599-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenaseUniRule annotation
Short name:
IMPDUniRule annotation
Short name:
IMPDHUniRule annotation
Gene namesi
Name:guaBUniRule annotation
Ordered Locus Names:LA_1986
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Inosine-5'-monophosphate dehydrogenasePRO_0000415689Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA1986.

Structurei

3D structure databases

ProteinModelPortaliQ8F4Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 17060CBS 1UniRule annotationAdd
BLAST
Domaini174 – 23057CBS 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni357 – 3593IMP bindingUniRule annotation
Regioni380 – 3812IMP bindingUniRule annotation
Regioni404 – 4085IMP bindingUniRule annotation

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165752.
InParanoidiQ8F4Q4.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 1 hit.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F4Q4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNQTYRDSE YLDGLSGEEL FNLQIGLTYR DFLVLPGFID FHPSEVELET
60 70 80 90 100
RLTRNIKLKR PFISSPMDTV TESQMAIAQA LMGGIGIIHY NNTIEEQVAL
110 120 130 140 150
VEKVKRFENG FITDPVILGP KNVIRDLDAI KERKGFTGIP VTEDGTRNSK
160 170 180 190 200
LIGIVTNRDI DFEKNREITL DKVMTTNLIT GKEGITLQDA NEIIKKSKIG
210 220 230 240 250
KLPIVDSQGK LVSLVSRSDL KKNKEFPDAS KDERKRLRCG AAVSTLLESR
260 270 280 290 300
DRVAALYEAG VDVIIIDSAQ GNSNYQIEMI QFIKKEFKNL DIVAGNVVTR
310 320 330 340 350
AQAENLIRAG ADGLRIGMGP GSICITQDTM AVGRAQATAI YQTAKHSAKY
360 370 380 390 400
DVPVIADGGI SNIGDIANSL AIGASTCMMG FMFAGTTEAP GEYFYENGIR
410 420 430 440 450
LKKYRGMASI EAMKAGGDKR YFNEGQKVKV AQGVSGSVVD RGSILNFIPY
460 470 480 490 500
LSQGLRLSFQ DMGYKSIPEI HKALRDGKLR FERRSESAQA QGSVHGLYSF

SAPTMRAE
Length:508
Mass (Da):55,881
Last modified:March 1, 2003 - v1
Checksum:i5D24AEC8D93512FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN49185.1.
RefSeqiNP_712167.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN49185; AAN49185; LA_1986.
GeneIDi1151329.
KEGGilil:LA_1986.
PATRICi22384813. VBILepInt91350_1979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN49185.1 .
RefSeqi NP_712167.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F4Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA1986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN49185 ; AAN49185 ; LA_1986 .
GeneIDi 1151329.
KEGGi lil:LA_1986.
PATRICi 22384813. VBILepInt91350_1979.

Phylogenomic databases

HOGENOMi HOG000165752.
InParanoidi Q8F4Q4.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci LINT189518:GJBB-1599-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 1 hit.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiIMDH_LEPIN
AccessioniPrimary (citable) accession number: Q8F4Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3