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Q8F4Q4

- IMDH_LEPIN

UniProt

Q8F4Q4 - IMDH_LEPIN

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, LA_1986
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei267 – 2671NAD By similarity
Metal bindingi319 – 3191Potassium; via carbonyl oxygen By similarity
Metal bindingi321 – 3211Potassium; via carbonyl oxygen By similarity
Binding sitei322 – 3221IMP By similarity
Active sitei324 – 3241Thioimidate intermediate By similarity
Metal bindingi324 – 3241Potassium; via carbonyl oxygen By similarity
Binding sitei432 – 4321IMP By similarity
Metal bindingi492 – 4921Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 3193NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciLINT189518:GJBB-1599-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:LA_1986
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000415689Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA1986.

Structurei

3D structure databases

ProteinModelPortaliQ8F4Q4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 17060CBS 1
Add
BLAST
Domaini174 – 23057CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni357 – 3593IMP binding By similarity
Regioni380 – 3812IMP binding By similarity
Regioni404 – 4085IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165752.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 1 hit.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8F4Q4-1 [UniParc]FASTAAdd to Basket

« Hide

MSNQTYRDSE YLDGLSGEEL FNLQIGLTYR DFLVLPGFID FHPSEVELET    50
RLTRNIKLKR PFISSPMDTV TESQMAIAQA LMGGIGIIHY NNTIEEQVAL 100
VEKVKRFENG FITDPVILGP KNVIRDLDAI KERKGFTGIP VTEDGTRNSK 150
LIGIVTNRDI DFEKNREITL DKVMTTNLIT GKEGITLQDA NEIIKKSKIG 200
KLPIVDSQGK LVSLVSRSDL KKNKEFPDAS KDERKRLRCG AAVSTLLESR 250
DRVAALYEAG VDVIIIDSAQ GNSNYQIEMI QFIKKEFKNL DIVAGNVVTR 300
AQAENLIRAG ADGLRIGMGP GSICITQDTM AVGRAQATAI YQTAKHSAKY 350
DVPVIADGGI SNIGDIANSL AIGASTCMMG FMFAGTTEAP GEYFYENGIR 400
LKKYRGMASI EAMKAGGDKR YFNEGQKVKV AQGVSGSVVD RGSILNFIPY 450
LSQGLRLSFQ DMGYKSIPEI HKALRDGKLR FERRSESAQA QGSVHGLYSF 500
SAPTMRAE 508
Length:508
Mass (Da):55,881
Last modified:March 1, 2003 - v1
Checksum:i5D24AEC8D93512FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN49185.1.
RefSeqiNP_712167.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN49185; AAN49185; LA_1986.
GeneIDi1151329.
KEGGilil:LA_1986.
PATRICi22384813. VBILepInt91350_1979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN49185.1 .
RefSeqi NP_712167.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F4Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA1986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN49185 ; AAN49185 ; LA_1986 .
GeneIDi 1151329.
KEGGi lil:LA_1986.
PATRICi 22384813. VBILepInt91350_1979.

Phylogenomic databases

HOGENOMi HOG000165752.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci LINT189518:GJBB-1599-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 1 hit.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiIMDH_LEPIN
AccessioniPrimary (citable) accession number: Q8F4Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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