ID   Q8F4B9_LEPIN            Unreviewed;       326 AA.
AC   Q8F4B9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   SubName: Full=Sigma factor regulatory protein {ECO:0000313|EMBL:AAN49321.1};
GN   OrderedLocusNames=LA_2122 {ECO:0000313|EMBL:AAN49321.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN49321.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN49321.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN49321.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010300; AAN49321.1; -; Genomic_DNA.
DR   RefSeq; NP_712303.1; NC_004342.2.
DR   RefSeq; WP_001049331.1; NC_004342.2.
DR   AlphaFoldDB; Q8F4B9; -.
DR   STRING; 189518.LA_2122; -.
DR   PaxDb; 189518-LA_2122; -.
DR   EnsemblBacteria; AAN49321; AAN49321; LA_2122.
DR   GeneID; 61141693; -.
DR   KEGG; lil:LA_2122; -.
DR   PATRIC; fig|189518.3.peg.2115; -.
DR   HOGENOM; CLU_852048_0_0_12; -.
DR   InParanoid; Q8F4B9; -.
DR   OrthoDB; 342342at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156:SF12; STAGE II SPORULATION PROTEIN E; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        45..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          102..325
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
SQ   SEQUENCE   326 AA;  37920 MW;  FCE85A6657776B58 CRC64;
     MNLKDYIKSY FQRVGWIPPI INLVCFIAPI VFLQNSSFSE KEKILLYLGI IGFIYLVNYI
     SFIFFLTKKI LPEEEIRSKM RKRYRKGDDR MQSYLFPLPL DDENYEIYGR TLTYNPIGGD
     FYNFLTDPQG NYWIGIGDSV GHGYLAGIFS MMIFQNMSLL VKHNLSPYEV IEQINEDLLK
     RTEQNPKINP NLYATFLLIK IDKEGNLEHS GLHPSFVIHQ KKTRKNKIIE TDGKFVSITM
     NSTLKNVQGK SKFQLETGDI VFCFTDGLYE QKNNGNLYFG ESLFQFLDEI PKNDLTKIAD
     VLFTEILKHT GGKLQDDMTI LMIRKK
//