true2004-05-102024-03-27119LIPA_LEPINUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.Ren S.-X.Fu G.Jiang X.-G.Zeng R.Miao Y.-G.Xu H.Zhang Y.-X.Xiong H.Lu G.Lu L.-F.Jiang H.-Q.Jia J.Tu Y.-F.Jiang J.-X.Gu W.-Y.Zhang Y.-Q.Cai Z.Sheng H.-H.Yin H.-F.Zhang Y.Zhu G.-F.Wan M.Huang H.-L.Qian Z.Wang S.-Y.Ma W.Yao Z.-J.Shen Y.Qiang B.-Q.Xia Q.-C.Guo X.-K.Danchin A.Saint Girons I.Somerville R.L.Wen Y.-M.Shi M.-H.Chen Z.Xu J.-G.Zhao G.-P.doi:10.1038/nature015972003Nature422888-893NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]56601Radical_SAMAldolase class ILipoyl_synthAldolase_TIMElp3/MiaA/NifB-like_rSAMLipoyl_synthrSAMlipALIPOYL SYNTHASELIPOYL SYNTHASE, MITOCHONDRIALRadical_SAMLipoyl_synthlipoyl_synthaselipoyl_synthase_likeElp3Radical SAM enzymesRADICAL_SAMLipoyl synthase2.8.1.8Lip-synLSLipoate synthaseLipoic acid synthaseSulfur insertion protein LipAlipALA_2292Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Belongs to the radical SAM superfamily. Lipoyl synthase family.Lipoyl synthase337241301Radical SAM core65279535864798386290124Fe-4S-S-AdoMet2003-03-0113372468507caf5beac9df8f9e17424f97ee8dMNPLKKKPRTHSLQNAPEKPDWLKVKLAFPDPKNNPVAIVRNSLEEKKLNTVCESASCPNLNHCWSRKTATYMLGGDICTRRCSYCDVASGKPFPLDPEEPKRIAESSIALDLRHVVITSVNRDDLEDGGAAHFAKTVKEIRKGLPDCKIELLIPDLKVKQEALEIIFECNPDIFNHNLETVKRLFPEVAPQKRYERSLDVLKIASARGFLTKSGLILGMGETLEEVKECMQDLASVGVSLLTLGQYLQPTSTHLPVKEYVVPQVFKDLRIYGKSIGFKGVFSGPLVRSSYHADEQISWNPtruetrue