Reviewed,
UniProtKB/Swiss-Prot Q8F3P1 (NRDJ_LEPIN)
Last modified
November 3, 2009.
Version 38.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Vitamin B12-dependent ribonucleotide reductase EC=1.17.4.1 Alternative name(s): Ribonucleoside-diphosphate reductase nrdJ | ||||
| Gene names |
| ||||
| Organism | Leptospira interrogans [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 173 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira |
Protein attributes
| Sequence length | 1209 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity. |
| Catalytic activity | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. |
| Cofactor | 5'-deoxyadenosylcobalamine (coenzyme B12) By similarity. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase class-2 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA synthesis |
| Ligand | Cobalamin Cobalt Nucleotide-binding |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | class II ribonucleotide reductase activity Inferred from electronic annotation. Source: InterPro cobalamin bindingInferred from electronic annotation. Source: UniProtKB-KW cobalt ion bindingInferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1209 | 1209 | Vitamin B12-dependent ribonucleotide reductase | PRO_0000231660 | |||||
Sites | |||||||||
| Active site | 207 | 1 | By similarity | ||||||
| Active site | 492 | 1 | By similarity | ||||||
| Active site | 503 | 1 | By similarity | ||||||
| Active site | 1202 | 1 | By similarity | ||||||
| Active site | 1208 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing." Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H.  Zhao G.-P.Nature 422:888-893(2003) [PubMed: 12712204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 56601 / Serogroup Icterohaemorrhagiae / Serovar lai. |
Cross-references
Sequence databases | |
|---|---|
| AE010300 Genomic DNA. Translation: AAN49559.1. | |
| RefSeq | NP_712541.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1151703. |
| GenomeReviews | Gene locus LA_2360 in contig AE010300_GR. |
| KEGG | lil:LA2360. |
| NMPDR | fig|189518.1.peg.2360. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8F3P1. |
| OMA | LDYVFRE. |
Enzyme and pathway databases | |
| BioCyc | LINT189518:LA2360-MON. |
| BRENDA | 1.17.4.1. 258108. |
Family and domain databases | |
| InterPro | IPR013344. RDP_Rdtase_AdoCbl-dep. IPR000788. Ribncl_red_lg_C. IPR013678. Ribonuc_red_2_N. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF08471. Ribonuc_red_2_N. 1 hit. PF02867. Ribonuc_red_lgC. 1 hit. [Graphical view] |
| PRINTS | PR01183. RIBORDTASEM1. |
| TIGRFAMs | TIGR02504. NrdJ_Z. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | NRDJ_LEPIN | ||||||||
| Accession | Primary (citable) accession number: Q8F3P1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
