ID   Q8F3G8_LEPIN            Unreviewed;       938 AA.
AC   Q8F3G8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Serine/threonine phosphatase containing GAF domains {ECO:0000313|EMBL:AAN49634.1};
GN   OrderedLocusNames=LA_2435 {ECO:0000313|EMBL:AAN49634.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN49634.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN49634.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN49634.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN49634.1; -; Genomic_DNA.
DR   RefSeq; NP_712616.1; NC_004342.2.
DR   RefSeq; WP_000612757.1; NC_004342.2.
DR   AlphaFoldDB; Q8F3G8; -.
DR   STRING; 189518.LA_2435; -.
DR   PaxDb; 189518-LA_2435; -.
DR   EnsemblBacteria; AAN49634; AAN49634; LA_2435.
DR   KEGG; lil:LA_2435; -.
DR   PATRIC; fig|189518.3.peg.2415; -.
DR   HOGENOM; CLU_312554_0_0_12; -.
DR   InParanoid; Q8F3G8; -.
DR   OrthoDB; 9773346at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   Gene3D; 3.30.450.40; -; 2.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
DR   SUPFAM; SSF81606; PP2C-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408}.
FT   DOMAIN          217..366
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          387..540
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          571..788
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
FT   COILED          355..385
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   938 AA;  106020 MW;  E1121CD2171D2ACF CRC64;
     MIPNKKQDSL LRQGSDGSLY LEDNPGLTVV FESLLTEIIH ITSAKFGIFS FRLEDGTLKS
     IYGNHPSNKI EEAKLVSEFC FKTGQDLNLK KGESPNKLIP QLEQNSVCCV LHVGELGDSS
     LEDQKKIFGT ILLGRSDQEG GEFRESDFIH LKATVRIISD LLEKSFISGE SSLVVLSLMT
     ISRVALESVQ IRKQTDRFDF LLTEIIRVSG LINKSLDLSQ LLEAIMLSSK SVFRTEACSV
     LLLDDTKEYL YFHTVLGEKR DEVTKVKVPV GKGIAGMVVQ DKKPMIINDA MNDPRVYREV
     DKASHFVTRN IMAAPLLVEG QVIGVIETIN TIDRNSFTEE DLELFLSFSG TSALAIQKTG
     LLQNLEDANK DLRKKVSELE SLFELSQVVS SAKSQADLMK HSIPVIHNEM DAGRTGIFLI
     NRRMGLLTCI SYTSEKIVEI FRTKDYQGSF IYRSVEEEKT TIKEDIQNFE FNHELDLEFL
     KGSYIVLPLT NPERNAFGVI TVSDRVDKLS YNYSHLRLLQ TFASLIARGH ETLKLQNEMI
     SRKAMQRSLE REIEITREIQ KNILPESKVF HSNFDLGVKS VPAKEVSGDF YDYYQYQDGQ
     YSFLISDVSG KSLPAAIFMA MSSSIIRTLA RDHDLDPEEI LKQGNALIYE DSHNGMFVTT
     FFIHYNPAIF TLDYASAGHN DQVLIRKDDS WEIIKGSGPP LGVLPSASYK GGSLTVEPGD
     MLILYTDGAI EEKNSKDEEF GLERMIREVI ARKHLTSQEI VEELFGLVRK FSGAPELFDD
     FTVMILKFND NYQFSRIFEA KTSEIPLFRE FVYQTIKVRN LEDSQRDDIL LACDEAGTNI
     VMHGYENTDL KNPKFECKIR FTGDWITIVL IDSGKVFHRE EVQDPSIEDN LSGKRKGGFG
     VYLIEKLMDS VDYSSEGGKN FLVLKKNFRN KASNGNNV
//