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Q8F397

- UPPP_LEPIN

UniProt

Q8F397 - UPPP_LEPIN

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciLINT189518:GJBB-2051-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:LA_2511
    OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
    Taxonomic identifieri189518 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001408: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Undecaprenyl-diphosphatasePRO_0000151161Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi189518.LA2511.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalUniRule annotationAdd
    BLAST
    Transmembranei44 – 6421HelicalUniRule annotationAdd
    BLAST
    Transmembranei89 – 10921HelicalUniRule annotationAdd
    BLAST
    Transmembranei122 – 14221HelicalUniRule annotationAdd
    BLAST
    Transmembranei154 – 17421HelicalUniRule annotationAdd
    BLAST
    Transmembranei195 – 21521HelicalUniRule annotationAdd
    BLAST
    Transmembranei224 – 24421HelicalUniRule annotationAdd
    BLAST
    Transmembranei257 – 27721HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiWRKISSS.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8F397-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPYLNAFLR SIIEAITEFL PVSSTGHLFL FSSFFPFYGE NVEFDDLFDI    50
    FIQSGAILSV LFLYREKFKS QIVSSFRYIL KQNSDSEGFH FLIQICIGAF 100
    PILIAGFIAK KFLDTIKARP DLLEILSGAW IFGGVLILVA EWYFHQRPEE 150
    KKSIGFKDSI LIGIFQCMAL IPGMSRSAAT IITARFLGKD TKSSAEFSFF 200
    LAVPVLLAAG IYKLIKYRSI LNGNTIPVLM FGFLVSFLLC TLVIRWFLRY 250
    IQKHSFSVFG VYRILLGVGV LVLTKLI 277
    Length:277
    Mass (Da):31,374
    Last modified:March 1, 2003 - v1
    Checksum:i664C38B6E9EFEE10
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010300 Genomic DNA. Translation: AAN49710.1.
    RefSeqiNP_712692.1. NC_004342.2.

    Genome annotation databases

    EnsemblBacteriaiAAN49710; AAN49710; LA_2511.
    GeneIDi1151854.
    KEGGilil:LA_2511.
    PATRICi22385854. VBILepInt91350_2493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010300 Genomic DNA. Translation: AAN49710.1 .
    RefSeqi NP_712692.1. NC_004342.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189518.LA2511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN49710 ; AAN49710 ; LA_2511 .
    GeneIDi 1151854.
    KEGGi lil:LA_2511.
    PATRICi 22385854. VBILepInt91350_2493.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi WRKISSS.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci LINT189518:GJBB-2051-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 56601.

    Entry informationi

    Entry nameiUPPP_LEPIN
    AccessioniPrimary (citable) accession number: Q8F397
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3