ID   Q8F2W9_LEPIN            Unreviewed;       445 AA.
AC   Q8F2W9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 2.
DT   27-MAR-2024, entry version 96.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN49843.2};
GN   Name=cyaA {ECO:0000313|EMBL:AAN49843.2};
GN   OrderedLocusNames=LA_2643 {ECO:0000313|EMBL:AAN49843.2};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN49843.2, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN49843.2, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN49843.2,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010300; AAN49843.2; -; Genomic_DNA.
DR   RefSeq; NP_712825.2; NC_004342.2.
DR   AlphaFoldDB; Q8F2W9; -.
DR   STRING; 189518.LA_2643; -.
DR   PaxDb; 189518-LA_2643; -.
DR   EnsemblBacteria; AAN49843; AAN49843; LA_2643.
DR   KEGG; lil:LA_2643; -.
DR   PATRIC; fig|189518.3.peg.2625; -.
DR   HOGENOM; CLU_570848_0_0_12; -.
DR   InParanoid; Q8F2W9; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        40..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          261..396
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   445 AA;  50748 MW;  B3737F43D6C486E2 CRC64;
     MNPFQSIQKM FHTLDRKSMP DSVLDVLQKE ERSGIIITNY FRYLIALFFL VQIAVNVENG
     NGKFNFIAFS IYLFLTLSHT IVIRVCPISI VNVFNYFTLF AEYLLILGVL LFYTFTIKNV
     NLGFALKHTI NLFFLFPIIY SLLQFKIRFV FIGLFLFYAI YFSILWIAVS TNQLTYTKDW
     GHYISGPGIL IEDIVAGKPG MYFCFAMMIS MGIFRTISMV RRIGIAEGQK TELSRYFSPK
     IVNEMVENPG ALQNGNRQIV SILFLDIRNF TAMSENMNPE ELSNFLSEFR KIMMECVFEH
     NGTLDKYIGD AVMATFGTPH PSPSAEVDAR NAVGCGVIMQ KRLSEWNLLR KSEGKTSISI
     GIGIHTGEVF AGNIGNDLHR EYSVIGDAVN TASRIESICK VLKKSFLISK ETMELLGGKY
     TLNRMPRVKV KGKQEPLQLY EVVWR
//