ID   Q8F2D7_LEPIN            Unreviewed;       423 AA.
AC   Q8F2D7;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN50033.1};
GN   Name=cyaA {ECO:0000313|EMBL:AAN50033.1};
GN   OrderedLocusNames=LA_2834 {ECO:0000313|EMBL:AAN50033.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50033.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN50033.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN50033.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN50033.1; -; Genomic_DNA.
DR   RefSeq; NP_713015.1; NC_004342.2.
DR   RefSeq; WP_001974549.1; NC_004342.2.
DR   AlphaFoldDB; Q8F2D7; -.
DR   STRING; 189518.LA_2834; -.
DR   PaxDb; 189518-LA_2834; -.
DR   EnsemblBacteria; AAN50033; AAN50033; LA_2834.
DR   GeneID; 61144516; -.
DR   KEGG; lil:LA_2834; -.
DR   PATRIC; fig|189518.3.peg.2817; -.
DR   HOGENOM; CLU_648595_0_0_12; -.
DR   InParanoid; Q8F2D7; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00065; GAF; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408}.
FT   DOMAIN          245..371
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   423 AA;  47158 MW;  7303B2BCDF45B97F CRC64;
     MSDNQDVEDF KKQFVENQKG IEELNQKLHR KTREVEIIQS ISAEILNTLD LEQIFERIME
     VMDEVFGFKH AMILMLEEGT ETLSVKASRG YEQGGVGAKV EFGQGVIGVV AKRKKIMRMV
     GITTQMRYAG QIGQSMGREE KQIELPGLKD AKSQIAIPLL VKDKLLGVFA VESAEMNAFK
     LLDEVILSVV GNQIAVAIEN AAAYYTQQQL SEAYSRFVPK ELLSLLSKKS ILETQLADQT
     EGLMTVMFSD IRGFTTISEK MTPSENFQFI NNYLGMIAPV IKEHNGFIDK FIGDAIMAIF
     PARAENAVEA ALAMMKALQQ FNELRQKENQ DPIDIGIGIH TGHLMLGIIG HENRMEGTVI
     GDSVNLASRI EGLTKQFKCS IIVSEVTIAS LRDPSRFTHS FLDEVTVKGK SQPIKVYKIE
     NSV
//