Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8F242

- PUR5_LEPIN

UniProt

Q8F242 - PUR5_LEPIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLINT189518:GJBB-2372-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:LA_2935
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148220Add
BLAST

Proteomic databases

PaxDbiQ8F242.

Interactioni

Protein-protein interaction databases

STRINGi189518.LA2935.

Structurei

3D structure databases

ProteinModelPortaliQ8F242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
InParanoidiQ8F242.
KOiK01933.
OMAiEFEMYRT.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8F242-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKITYKNA GVDTEKGREF IQKIKRNVES THGPRVIGGL GGFAGAYDVS
60 70 80 90 100
VLKKYKHPIL LSGTDGVGTK IELARLLKIY NTIGIDLVAM CVNDILVCGG
110 120 130 140 150
EPLFFLDYIA CGKLDPEKMD QIVSGIVQGC KMSNASLLGG ETAEHPGTMK
160 170 180 190 200
EDEFDLAGFV VGAVEKDSMI DGSTIRSGDK ILGLESSGPH SNGFSLIRKL
210 220 230 240 250
LLKEGKYLPT DPQQVKFLKD YALKPTRIYV SSILKLLQQV SVKGMVHITG
260 270 280 290 300
GGYQENVPRI LPQGTQSKFF KEKIPSGYFF EKIKKDHKIE ELELFATFNM
310 320 330 340
GIGYMVIVSE ENAELAKKIM ESSGEVVHEI GEIVSGNKEE VQFV
Length:344
Mass (Da):37,761
Last modified:November 28, 2003 - v2
Checksum:i266AF4D7F5C837EE
GO

Sequence cautioni

The sequence AAN50133.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN50133.2. Different initiation.
RefSeqiNP_713115.2. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN50133; AAN50133; LA_2935.
GeneIDi1152277.
KEGGilil:LA_2935.
PATRICi22386700. VBILepInt91350_2914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN50133.2 . Different initiation.
RefSeqi NP_713115.2. NC_004342.2.

3D structure databases

ProteinModelPortali Q8F242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA2935.

Proteomic databases

PaxDbi Q8F242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN50133 ; AAN50133 ; LA_2935 .
GeneIDi 1152277.
KEGGi lil:LA_2935.
PATRICi 22386700. VBILepInt91350_2914.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
InParanoidi Q8F242.
KOi K01933.
OMAi EFEMYRT.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LINT189518:GJBB-2372-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiPUR5_LEPIN
AccessioniPrimary (citable) accession number: Q8F242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3