ID   Q8F210_LEPIN            Unreviewed;       441 AA.
AC   Q8F210;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN50166.1};
GN   Name=cyaA {ECO:0000313|EMBL:AAN50166.1};
GN   OrderedLocusNames=LA_2968 {ECO:0000313|EMBL:AAN50166.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50166.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN50166.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN50166.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN50166.1; -; Genomic_DNA.
DR   RefSeq; NP_713148.1; NC_004342.2.
DR   RefSeq; WP_000247973.1; NC_004342.2.
DR   AlphaFoldDB; Q8F210; -.
DR   STRING; 189518.LA_2968; -.
DR   PaxDb; 189518-LA_2968; -.
DR   EnsemblBacteria; AAN50166; AAN50166; LA_2968.
DR   GeneID; 61144418; -.
DR   KEGG; lil:LA_2968; -.
DR   PATRIC; fig|189518.3.peg.2945; -.
DR   HOGENOM; CLU_629576_0_0_12; -.
DR   InParanoid; Q8F210; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          262..392
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   441 AA;  49289 MW;  C69CA3B2E8761CE0 CRC64;
     MVNPIQELTK KFKKPTMDPL SYEILKSEII RTKILFIFFA STSVIMSVIF VVFHEWIVKE
     TGGHFPFYAV LGVNLGTAIY ELIINRVFNR FLQKRKGVFS VARFGNVLIE ISSVGLLLWF
     NIGAFASPLI PLYSPAVLTF FIFIILSVLR LEFWLSAFTG FVAGAELLVL AILYIPQNPI
     PMPINFFNSV APFISKSLLF FFSGIAAGLV GIQLKRSLIS AMSAVQEKNK VVGMFGQYVS
     PDVVDRLLEQ KNESFSEFKR VCVMFLDIRN FTRFSEKRPP GEVIDYLNYI FSHLIDIVNV
     HNGMINKFLG DGFMAVFGAP ISDGGNDVKN AVEASLELLK KIEFLNQEGK IPETQIGIGL
     HTGEAMTGNV GSEARKEYTI IGDVVNLASR VESLNKEFGT KLLVTQAVYD DIKDTVPGRH
     LSSIHVKGRE EPVDVYELGK I
//