ID   Q8F1A2_LEPIN            Unreviewed;       436 AA.
AC   Q8F1A2;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN50432.1};
GN   Name=cyaA {ECO:0000313|EMBL:AAN50432.1};
GN   OrderedLocusNames=LA_3234 {ECO:0000313|EMBL:AAN50432.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50432.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN50432.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN50432.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; AE010300; AAN50432.1; -; Genomic_DNA.
DR   RefSeq; NP_713414.1; NC_004342.2.
DR   AlphaFoldDB; Q8F1A2; -.
DR   STRING; 189518.LA_3234; -.
DR   PaxDb; 189518-LA_3234; -.
DR   EnsemblBacteria; AAN50432; AAN50432; LA_3234.
DR   KEGG; lil:LA_3234; -.
DR   PATRIC; fig|189518.3.peg.3210; -.
DR   HOGENOM; CLU_016487_0_0_12; -.
DR   InParanoid; Q8F1A2; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd18774; PDC2_HK_sensor; 1.
DR   Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        125..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          144..196
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          228..360
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   436 AA;  48540 MW;  836FD63CBD48F3A2 CRC64;
     MYLSIFVGDK NNSAILVSLV KMDSILDSFK TSGITQFFLV GNDGALIAHS DSKLILQPTD
     LKDEPIVKNL LESAISNGQT RYKGKDDQYY LGSFRRIGYA GLGVISSTSE KKAFEEVYNI
     QKRNIYLMIV VVNVSILFVF FYARRLTRPI LKLVDASKQI EQGNFHIDLK PESGDEIGRL
     TSSFVEMGKG LSDRDKMKDA FGKFVNKDIA EMVLRGEVKL GGDKRECVIL FSDIRNFTSI
     SEKIEPELVV EFLNQYFTAM VKCINENGGS VNKYIGDAIM AVWGELGHTN SDTERSILAA
     LDMRKSLIQF NKGRGSDKKP KIFIGIGINT GEVIAGQIGS EDRLEYTVIG DTVNLASRVE
     SLTKVFGADI LITGNSYEKV KGIFNVEKLK PIQVKGKKSL QTIYAVLGHS KDKNCPKNLK
     ELRKQIGMEF KSGRSK
//