ID   Q8F0P2_LEPIN            Unreviewed;       598 AA.
AC   Q8F0P2;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   SubName: Full=Regulatory protein {ECO:0000313|EMBL:AAN50648.1};
GN   OrderedLocusNames=LA_3450 {ECO:0000313|EMBL:AAN50648.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50648.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN50648.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN50648.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN50648.1; -; Genomic_DNA.
DR   RefSeq; NP_713630.1; NC_004342.2.
DR   RefSeq; WP_001110368.1; NC_004342.2.
DR   AlphaFoldDB; Q8F0P2; -.
DR   STRING; 189518.LA_3450; -.
DR   PaxDb; 189518-LA_3450; -.
DR   EnsemblBacteria; AAN50648; AAN50648; LA_3450.
DR   KEGG; lil:LA_3450; -.
DR   PATRIC; fig|189518.3.peg.3416; -.
DR   HOGENOM; CLU_456206_0_0_12; -.
DR   InParanoid; Q8F0P2; -.
DR   OrthoDB; 305353at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR031621; HisKA_7TM.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156:SF12; STAGE II SPORULATION PROTEIN E; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF16927; HisKA_7TM; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          384..597
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
SQ   SEQUENCE   598 AA;  68795 MW;  1BF823A219B68A0F CRC64;
     MNYYLFLPMI AFVANTMFIA FVYARRTKNP VIRSYLLYTI ILETWLFTHI FYWASPFETW
     TTWAFRILSI TWLPVGLFYL EFVYIFSQNL NSRTQTTKSR SLLGFKTFSL EIFLWFFRIG
     IPILYLITLF TNWIIHGTAH YYWGNENEPS PLYYFVILIF ITFPSFIGLG ILTKSLLTSE
     GEQKKQISLV LFGSTFLILA SLYYEVIQID DQGRLLSPPL TSIGILVQSF LIFIAITRYG
     FLKINVEGLA TELFRDIHDG MILIEQDRSL FFINESAIKI LGISNFLPSH FFPSDFLKDY
     QENLDHFSKE YKPVFNADCR GIELTRSNIQ LTGKGNGHLF ILRDISEKIE SREKIESIYS
     AFNKDLEIAK IAQTSAISTK FPESRKFKFY SHFQPFELVG GDFLKALQRS DGKLDVFFAD
     VSGHGISSAM VTGMLSISFQ LAVETNPTPK EALEKIQSLL LNAVLNHHVS AVYFSFDPNT
     KILEYSYAGH HPILVFREGK VIPLEGEGRI LLITSETELN NYTFQFKKGD IVFLYSDCLF
     EVRNASGEIF GYENFIQKMS EIPIYSPSKI LKTAIDLALN FNNGKLTDDL TILILEIL
//