ID   Q8F087_LEPIN            Unreviewed;       699 AA.
AC   Q8F087;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 2.
DT   27-MAR-2024, entry version 101.
DE   SubName: Full=Serine phosphatase RsbU, regulator of sigma subunit {ECO:0000313|EMBL:AAN50807.2};
GN   OrderedLocusNames=LA_3610 {ECO:0000313|EMBL:AAN50807.2};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50807.2, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN50807.2, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN50807.2,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010300; AAN50807.2; -; Genomic_DNA.
DR   RefSeq; NP_713789.2; NC_004342.2.
DR   RefSeq; WP_001160641.1; NC_004342.2.
DR   AlphaFoldDB; Q8F087; -.
DR   STRING; 189518.LA_3610; -.
DR   PaxDb; 189518-LA_3610; -.
DR   EnsemblBacteria; AAN50807; AAN50807; LA_3610.
DR   GeneID; 61143943; -.
DR   KEGG; lil:LA_3610; -.
DR   PATRIC; fig|189518.3.peg.3580; -.
DR   HOGENOM; CLU_402144_0_0_12; -.
DR   InParanoid; Q8F087; -.
DR   OrthoDB; 311727at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          474..693
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
SQ   SEQUENCE   699 AA;  79983 MW;  8126FDA10BB69CB1 CRC64;
     MQFSKIFFFL IGPFALIILV MISSPWQAGD GLRAYQGKID LRGIQDPDFG MTKLNGEWEF
     SWLQGPEKGI ENHSVEFIGV PGSWTNESKS NQTYPKFGYG IYRLKVFLPE IWKKKILSVS
     LGAIASAYRI KINEQIIGEC GTPGIDPDSI VSRIEPRDFL FFADEDEVQI EIFVSNYTST
     MPGILLPISI GPSDSAGVSK AIPLFFDIFS FSSLLIMGIY HIFQYLYLRS SVSPLYFGMY
     SLVICLRTSL INSKILMLFF PQIPWSWVHK INHLTLSVGV PFFLLFFSSI FAPYVSRKFI
     NVGVVFSILF SIVTLFGDMT FNNQSISIYH YFIIIIICYL FYTILKIDFD KERNYTYILY
     GSGILFIAVL VDLFYARVLK TGSIQTSHYA LVFFVFLQSL LLASERSRKF AETRELALNL
     RTSNLELFEM KEQLVQKIED RTRVLNDNII QINRELEIAQ NVQRKILTPL DRNIPGIRFY
     YEYKPLEKVG GDFLDISEIS SGKTRVLIAD AVGHGVQASL MTMALKTEYE ELKNLENPAQ
     VLKELNFRFL KKFDSLESIF PCMIGDIDTE KEEFTYASAG HPDQILQLPG EFPSLLQKTG
     PILGLFESLE IVSKTIIFPT GSRLLLFSDG LIENRMKDSL NTKQHNMELI TKTLHEGRES
     ELKNLIQEII KIEELTRGEN PRYDDITVIA VEFYSVKRS
//