ID   Q8EZX6_LEPIN            Unreviewed;      2785 AA.
AC   Q8EZX6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Cytoplasmic membrane protein {ECO:0000313|EMBL:AAN50923.1};
GN   OrderedLocusNames=LA_3725 {ECO:0000313|EMBL:AAN50923.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50923.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN50923.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN50923.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN50923.1; -; Genomic_DNA.
DR   RefSeq; NP_713905.1; NC_004342.2.
DR   RefSeq; WP_011069769.1; NC_004342.2.
DR   STRING; 189518.LA_3725; -.
DR   PaxDb; 189518-LA_3725; -.
DR   EnsemblBacteria; AAN50923; AAN50923; LA_3725.
DR   KEGG; lil:LA_3725; -.
DR   PATRIC; fig|189518.3.peg.3702; -.
DR   HOGENOM; CLU_230899_0_0_12; -.
DR   InParanoid; Q8EZX6; -.
DR   OrthoDB; 309913at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00081; Hint; 1.
DR   Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR030934; Intein_C.
DR   InterPro; IPR030885; Lepto_longest.
DR   NCBIfam; TIGR01443; intein_Cterm; 1.
DR   NCBIfam; TIGR04388; Lepto_longest; 1.
DR   Pfam; PF07591; PT-HINT; 1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 2.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2240..2268
FT                   /note="Intein C-terminal splicing"
FT                   /evidence="ECO:0000259|PROSITE:PS50818"
FT   COILED          215..249
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2785 AA;  305029 MW;  743BE099DD3C4930 CRC64;
     METKLEKRYI IEISYSLRAL VFSLLLSVFS PLYAPPVVVP NLNTPVFNAT SMDQTFNVAN
     GMQTVGNWDS FVFQGVSILQ TQWEAQVQAQ ITMMVNSITT SDHYASVQEY QTYVYNSLQS
     KASEQLIVWQ TAVEAEILQE RSQYLSQKYG ANSNAVQNST SQFQSQWDSF VSGNGLNLNM
     NGSLSQTVLN SGQQTLEGLE GQWWNDFQNN LQSGLQTYQQ ALAGLTEKYQ NLINQINQTE
     LQYQAHLAQI QQSQAGIKDQ ILSSLEGYQS FLNSNGLFWN TMSVVYDNNT NSYVQGSCPG
     GHVCVTYQYD SVTSQFYTAG NCPVGHVCAN VLYDNNTSSY VQASCPAGHI CDGTEKENLT
     VRTGLNADGR AFQNVINNVV NAMQDGFVMP AIFDYTTGTM ISYNSNCMNT GTSCIKGLYD
     ATSGNFVAGT ACAAGHTCYS AVVDNTNPAS MTGSYFANSC TVGDSRCVTC QAGHSCQVQD
     MEASFLYASN MMNTFLNNEL LATQGALQSA INYQNGSGSS SYTYGQGVGS YDNSALSYQW
     GPSGFSHFSA HVSQTTAAMT ISELFNPSVT EGEGGLGKKI IEYITGQISQ VEFANWIMNA
     YESNLTGAGS TLAGLGGLGP GMTISGISHA DLRAFLNEDI PPGNFGPNQY CPDPIGCYSG
     NIFAPDPGIY GANDTFSQRG YDFNRYIARE LGVWAGVPFL ADIEHYQDYA WIELSFTVTN
     NNAYANVSTY QDLVLQLQGF QHDWMTNVMP SITNWTAQVA SYNAQYANWQ TQMQTAITDA
     QNAYNSGVQD IQSQESSWLA QMGQLQQQAQ SAFDAASNAL KNGQGQGNYG QLTQQILAGL
     NKGQLQSNIS NSTDTMQYGD GFSNILNNLD RNADRGIPNF SLLSSFGSSM SRAITGVSNL
     TLLSSTNNAL MDNILGYMQG VADSMRNEKQ FTQNGQQDLM EAHGLKTKTI KTKDKYSGED
     ISTTYVLDEN GNIRTFKDED GVEKQMTVGD WIQSDEGCGK NLMNGNCNQY IENKYDSVAI
     GADGKITANR KIYNGTTSQC GADFAQASSY CYNEDDRVVT IAPPNPKALL LGRGASRLGD
     IFDGRDNGIG ELVNTTFQNV GTYLSSNKYT ADLFHEVITA QNLNDMNASI ASQDVSNKVK
     IANLIVDYAQ AVLLGGMSTG SWVTKQANQA VQDVISTVLV NTFDLPPDVA AFLSGGLMAH
     MEASKAKHDL GNRNLGIGKA VHSAFNDLGL EGFESALIHA AGPILDVVIA PGVGALSKST
     LDSYGNNLDS MHKWKEFKTS MYGFAVQKIG EQQHWSPEFT SFASQYAMDY IEMKEAKAEL
     GRNGAAFSLN SIAGELKLAI ANICGALGEV IGAGVNGMTH LSGDLGLTSE RYEKEINQQV
     RTSINDIKLK GYKDSIRTWD ADQVGLASAS VKEYGRVNHW DQATVEMWSQ QASDFVVRKQ
     AERDLHKRND AIGLTALTNP VSAFMFLDNK LFSGGLTSLV TKGVKGIMTT IADAGNLLGE
     GVVSSSFRNS VYDQTKDWKN IVTQEDVKAR TQQGIINKAH IESEMRNQLF DIIGQTLMPG
     DKEAAHNLGL LLKYHIDQKE AKKAAKEQRL RDAQTVVQVA AAAAMVACSA GTTGPLAGTW
     LSGLTTTAVS TTIAGTTATL TYGQIAALAI STAVSMGVEG SINGTNGAVA ALANGLISAA
     TMGIKTPVTG YVTYTKHQNA NLLTGQHEVK GGWGGGISGN IAGSKALPVG EAMQAFAAAM
     KMSNLSLGFS YNRDAGLGMN VNANFTNKLG LGLDYNFKSG DYTANASYDF DKVGGKDWAN
     ASLGISASKN GHASASVSYN TDGNTAIPQA LRGSGATLDF GNDGLIGLSV QAMRGATVGT
     LTYDTNTHGF QPLTLNNNYQ NEFNQGQAAE NAAYNHQKGQ MEILMKELSL GTKMDKPLFT
     QAEIDAALPK DEHGNLDMEK ANPEKLLDKW NAHKEARSKT PEGLQKWKDE VSKAGERSGI
     EVKFNDGKSA TSTFGKFVTG LMGDVAQSFG FANDGSKMID KAGVFHLDTC FVAGSKVTKL
     KNKNIKIYGN TNISSTSNGA NLSGFNSEDY EFANIEEIRI GDVVRSWNEN TNTFENKRVT
     ETFVHEVPQL FFLELDGEEE IHTTWNHPFR RYRATQESEP NRNERQSAGY GVERGFENHS
     VEHSRNVALE NRDITETSHL TPNQLAPNVS KILATGNYSL TPQSEWVKVE DLRLRDQVLR
     SDGSWGTVTG IYYYNTEPTK VYNLEVEDNH TYVVGGSETG KGYVVHNYIV DQKDKFLSGA
     EVEKAYKDHK KMGEKAEIKW GDKTYKKVNG EGEGVAVFVR DYDEKGTKEY IRITKDGLIE
     QKIKWKGQLG EFMANTLSGE KTKYFNTRGE EVFLQPDKLV RDGGSKKLPF DPVDTKLANN
     IVDKVKNDYE QSLRTEYAND KKSKLTPAQI DVKVKAEMAV YNRIADRTFR NSYTDEKGNA
     VQHGSDEFLK QVADPVFNGQ NSTKKPDGME IPVKVVIEYM RSKYPDGKGY TPNLAPWNER
     IATHKEKLND LNVELKTGLQ KEGMSDKERK SFQKDMEKKI ASESNKMYGV ELERRNRMEE
     FEKSSNLIFG KNSKGEYNVS SSEIAKQTKA AICRADTNYL QNRVNGRMEA SFGEYFMNKI
     EMGDIRPGTS QTKGLVWDNG YLKGYDDQYP PKGQDSIPES FDASNLYEGE PLSHDYIQEV
     TANMKPGQAI QVWVDTDVNK GDNSKPGPNH YYEISMNSKG EFVYLNHTGE VVKYKDESGR
     KVEIPFNTPI TKEAWAKLRI FRIYK
//