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Q8EZQ1

- GLMS_LEPIN

UniProt

Q8EZQ1 - GLMS_LEPIN

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei605 – 6051For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciLINT189518:GJBB-3018-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:LA_3801
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135350Add
BLAST

Proteomic databases

PaxDbiQ8EZQ1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA3801.

Structurei

3D structure databases

ProteinModelPortaliQ8EZQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini287 – 431145SIS 1UniRule annotationAdd
BLAST
Domaini459 – 600142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
InParanoidiQ8EZQ1.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8EZQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYAGK KNAESVLVVG LICLEYRGYD SAGIAVLDQG DILVRKSKGK
60 70 80 90 100
IKDLEAYLRE FPAPGNVGIG HTRWATHGEP NQINAHPHTD TNSTVAVVHN
110 120 130 140 150
GIIENYLELK SQLKKKGHVF QSLTDTEVLP HLLEESKKNG KSNKDSFLEL
160 170 180 190 200
FGKIHGKWAI SSVFETEPDR VYFAQDGAPL LIGKGKGEYF LASDISPLTR
210 220 230 240 250
NCEEVYYVNS GEWGYFSQNE FKLFDFSGKE LNPTFKKQEL RWEDLDKGGY
260 270 280 290 300
PHYMIKEIHE QAGIFRKIIQ ERILENSEIV FPEIKLSKDV LSRVNRIIIQ
310 320 330 340 350
AAGTSYYAGM IGKHYLENFA KIQTDTEASS EFRYRNPVVE GDTLIMGISQ
360 370 380 390 400
SGETADTLAS IHEAKAKFIK VVSLVNNVNS TIARESDSYI RTDAGPEIGV
410 420 430 440 450
ASTKAFTAQV LNLLLFSIYM ANLKWLISDE EQKILIEEIK LLPAKIDRIL
460 470 480 490 500
AQASKIEEMS SHFTTAKDFI FLGRTYNHPV AMEGALKLKE ISYIHASGYA
510 520 530 540 550
GGEFKHGPIA LITNEVPVVC IAPKSEIYTK MVSNIQEIKA RKGIIISIVT
560 570 580 590 600
EGDQEAKSLS DYCFEIPECS EILSPILNVI PLQLLAYYSA IARGCPPDQP
610
RNLAKSVTVE
Length:610
Mass (Da):67,943
Last modified:January 23, 2007 - v3
Checksum:i85E6305528C41667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN50999.1.
RefSeqiNP_713981.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN50999; AAN50999; LA_3801.
GeneIDi1153143.
KEGGilil:LA_3801.
PATRICi22388423. VBILepInt91350_3770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN50999.1 .
RefSeqi NP_713981.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8EZQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LA3801.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PaxDbi Q8EZQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN50999 ; AAN50999 ; LA_3801 .
GeneIDi 1153143.
KEGGi lil:LA_3801.
PATRICi 22388423. VBILepInt91350_3770.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
InParanoidi Q8EZQ1.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci LINT189518:GJBB-3018-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiGLMS_LEPIN
AccessioniPrimary (citable) accession number: Q8EZQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3