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Q8EZQ1

- GLMS_LEPIN

UniProt

Q8EZQ1 - GLMS_LEPIN

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, LA_3801
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei605 – 6051For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciLINT189518:GJBB-3018-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:LA_3801
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135350Add
BLAST

Proteomic databases

PaxDbiQ8EZQ1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA3801.

Structurei

3D structure databases

ProteinModelPortaliQ8EZQ1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini287 – 431145SIS 1
Add
BLAST
Domaini459 – 600142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8EZQ1-1 [UniParc]FASTAAdd to Basket

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MCGIVGYAGK KNAESVLVVG LICLEYRGYD SAGIAVLDQG DILVRKSKGK    50
IKDLEAYLRE FPAPGNVGIG HTRWATHGEP NQINAHPHTD TNSTVAVVHN 100
GIIENYLELK SQLKKKGHVF QSLTDTEVLP HLLEESKKNG KSNKDSFLEL 150
FGKIHGKWAI SSVFETEPDR VYFAQDGAPL LIGKGKGEYF LASDISPLTR 200
NCEEVYYVNS GEWGYFSQNE FKLFDFSGKE LNPTFKKQEL RWEDLDKGGY 250
PHYMIKEIHE QAGIFRKIIQ ERILENSEIV FPEIKLSKDV LSRVNRIIIQ 300
AAGTSYYAGM IGKHYLENFA KIQTDTEASS EFRYRNPVVE GDTLIMGISQ 350
SGETADTLAS IHEAKAKFIK VVSLVNNVNS TIARESDSYI RTDAGPEIGV 400
ASTKAFTAQV LNLLLFSIYM ANLKWLISDE EQKILIEEIK LLPAKIDRIL 450
AQASKIEEMS SHFTTAKDFI FLGRTYNHPV AMEGALKLKE ISYIHASGYA 500
GGEFKHGPIA LITNEVPVVC IAPKSEIYTK MVSNIQEIKA RKGIIISIVT 550
EGDQEAKSLS DYCFEIPECS EILSPILNVI PLQLLAYYSA IARGCPPDQP 600
RNLAKSVTVE 610
Length:610
Mass (Da):67,943
Last modified:January 23, 2007 - v3
Checksum:i85E6305528C41667
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN50999.1.
RefSeqiNP_713981.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN50999; AAN50999; LA_3801.
GeneIDi1153143.
KEGGilil:LA_3801.
PATRICi22388423. VBILepInt91350_3770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010300 Genomic DNA. Translation: AAN50999.1 .
RefSeqi NP_713981.1. NC_004342.2.

3D structure databases

ProteinModelPortali Q8EZQ1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 189518.LA3801.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PaxDbi Q8EZQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN50999 ; AAN50999 ; LA_3801 .
GeneIDi 1153143.
KEGGi lil:LA_3801.
PATRICi 22388423. VBILepInt91350_3770.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci LINT189518:GJBB-3018-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiGLMS_LEPIN
AccessioniPrimary (citable) accession number: Q8EZQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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