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Protein
Submitted name:

Adenylate/guanylate cyclase

Gene

LA_3843

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate/guanylate cyclaseImported
Gene namesi
Ordered Locus Names:LA_3843Imported
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)Imported
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001408 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei180 – 198HelicalSequence analysisAdd BLAST19
Transmembranei205 – 224HelicalSequence analysisAdd BLAST20
Transmembranei244 – 261HelicalSequence analysisAdd BLAST18
Transmembranei273 – 291HelicalSequence analysisAdd BLAST19
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Transmembranei328 – 345HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500430592622 – 681Sequence analysisAdd BLAST660

Interactioni

Protein-protein interaction databases

STRINGi189518.LA_3843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini443 – 569Guanylate cyclaseInterPro annotationAdd BLAST127

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili380 – 405Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4107YYZ. Bacteria.
COG2114. LUCA.
HOGENOMiHOG000143781.
InParanoidiQ8EZL0.
KOiK01768.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR011623. 7TMR_DISM_rcpt_extracell_dom1.
IPR011622. 7TMR_DISM_rcpt_extracell_dom2.
IPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF07695. 7TMR-DISM_7TM. 1 hit.
PF07696. 7TMR-DISMED2. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EZL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIIKILRIV FPILLTLPTF AETIPWNENQ VRLGIYSQIL EDQDSSLTIE
60 70 80 90 100
SVQNKEFQQS NQTNPSFGFT KSAYWLKFSF NNPEETFKEK LLEITFPLID
110 120 130 140 150
EVILYSPENG TYQQTIVGIE KPFTDRPIES HTFVFPIHAP PGVSTFYLRF
160 170 180 190 200
KNEDSMQMPL ILWEPDAFYK NIRDIQYING IYFGILIAMA VYNLFLLLTV
210 220 230 240 250
RDKSYFFYVF YILCFAIFLM SQYGFAYEYL WPEFSWGARR MNPFLAGLLE
260 270 280 290 300
FSILLFTRDF LDTKNTFPTL HKYNHVLIIL CAMASFSSFF VNLTQGALQV
310 320 330 340 350
AILGLLTAIS ILASGIKALM SGFRPARYFM IAFSALLLGG AFYALKTIGA
360 370 380 390 400
IPVSFVTEYS MQIGSGLEVT LLSLGLGDRI SILIKEKQET QKELIREQND
410 420 430 440 450
SIEKQAKLNE SFARFVPSKL IHLLGKNEVI QVALGDQIQK EMTVLFSDIR
460 470 480 490 500
SFTELSESMN PQENFNFLNS YLERMTLAIE KYSGTIDKFI GDAIMALFET
510 520 530 540 550
NAEDGLMAAI EMHRQLKLYN ADRDRQGYKP IETGIALHKG PVMLGTIGSQ
560 570 580 590 600
NRMEVTVISD TVNTTSRIEG LTKNYGAKIL LSETAFSSLK DPSQFLYRYL
610 620 630 640 650
GRTFVRGKKE DLSILEFCDT ESDEAEQFFK TKSKFEKGVF HFFEEEYTFA
660 670 680
FNHFRDVLSE YPTDSASAWY LQACRTSLKR E
Length:681
Mass (Da):78,126
Last modified:June 15, 2010 - v2
Checksum:i31A16364628425EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN51041.2.
RefSeqiNP_714023.2. NC_004342.2.
WP_000691480.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN51041; AAN51041; LA_3843.
GeneIDi1153185.
KEGGilil:LA_3843.
PATRICi22388515. VBILepInt91350_3815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN51041.2.
RefSeqiNP_714023.2. NC_004342.2.
WP_000691480.1. NC_004342.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA_3843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN51041; AAN51041; LA_3843.
GeneIDi1153185.
KEGGilil:LA_3843.
PATRICi22388515. VBILepInt91350_3815.

Phylogenomic databases

eggNOGiENOG4107YYZ. Bacteria.
COG2114. LUCA.
HOGENOMiHOG000143781.
InParanoidiQ8EZL0.
KOiK01768.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR011623. 7TMR_DISM_rcpt_extracell_dom1.
IPR011622. 7TMR_DISM_rcpt_extracell_dom2.
IPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF07695. 7TMR-DISM_7TM. 1 hit.
PF07696. 7TMR-DISMED2. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8EZL0_LEPIN
AccessioniPrimary (citable) accession number: Q8EZL0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.