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UniProtKB - Q8EZG6 (G6PI_LEPIN)

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei284Proton donorUniRule annotation1
Active sitei305UniRule annotation1
Active sitei419UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LA_3888
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteria › Spirochaetes › Leptospirales › Leptospiraceae › Leptospira ›
Proteomesi
  • UP000001408 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806651 – 445Glucose-6-phosphate isomeraseAdd BLAST445

Proteomic databases

PRIDEiQ8EZG6.

Interactioni

Protein-protein interaction databases

STRINGi189518.LA_3888.

Structurei

3D structure databases

ProteinModelPortaliQ8EZG6.
SMRiQ8EZG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
InParanoidiQ8EZG6.
KOiK01810.
OMAiSFIIPDD.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EZG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLETRFAS SFIQSSKLEP FLEKSESARL TLHSSQGQGK EYLGWLYLPK 
        60         70         80         90        100
ELKNSEIERM TQVAERLRNS SEVIVVIGIG GSYLGSRAVL EATLPFFKKP 
       110        120        130        140        150
SIGNPEIIFA GHHLESRYFS ELIEYLEDKN FSINVISKSG TTTEPAIAFR 
       160        170        180        190        200
LLWELLRKKY GSSASSRVVA TTDSSKGVLK KFADSEKLDT FTIPDNVGGR 
       210        220        230        240        250
YSVLTPVGLF PLAVAGISIS KFILGFQNIL NDIHSITDPT RNPATYYSAL 
       260        270        280        290        300
RNYFLSEGRY IEVLANFNPS LRYVSEWWKQ LFGESEGKEN KGIFPASMDF 
       310        320        330        340        350
TTDLHSLGQY IQEGKRILFE TVLSPSEVCS NLTLKPTQDN LDSLNFLSGN 
       360        370        380        390        400
TLGYVNEQAR LGTLLAHADG GVPCLELVFP DISPQSLGEL MYFFEYSCAI 
       410        420        430        440 
SGYSLGVNPF DQPGVEAYKK NMFALLNKPG FEQEGETLRK RISRN
Length:445
Mass (Da):49,735
Last modified:March 1, 2003 - v1
Checksum:i5ACA2EAC6387A6A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN51086.1.
RefSeqiNP_714068.1. NC_004342.2.
WP_000620160.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN51086; AAN51086; LA_3888.
GeneIDi1153230.
KEGGilil:LA_3888.
PATRICifig|189518.3.peg.3855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010300 Genomic DNA. Translation: AAN51086.1.
RefSeqiNP_714068.1. NC_004342.2.
WP_000620160.1. NC_004342.2.

3D structure databases

ProteinModelPortaliQ8EZG6.
SMRiQ8EZG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA_3888.

Proteomic databases

PRIDEiQ8EZG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN51086; AAN51086; LA_3888.
GeneIDi1153230.
KEGGilil:LA_3888.
PATRICifig|189518.3.peg.3855.

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
InParanoidiQ8EZG6.
KOiK01810.
OMAiSFIIPDD.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_LEPIN
AccessioniPrimary (citable) accession number: Q8EZG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.