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Q8EZG6 (G6PI_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:LA_3888
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifier189518 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_0000180665

Sites

Active site2841Proton donor By similarity
Active site3051 By similarity
Active site4191 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EZG6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5ACA2EAC6387A6A9

FASTA44549,735
        10         20         30         40         50         60 
MIRLETRFAS SFIQSSKLEP FLEKSESARL TLHSSQGQGK EYLGWLYLPK ELKNSEIERM 

        70         80         90        100        110        120 
TQVAERLRNS SEVIVVIGIG GSYLGSRAVL EATLPFFKKP SIGNPEIIFA GHHLESRYFS 

       130        140        150        160        170        180 
ELIEYLEDKN FSINVISKSG TTTEPAIAFR LLWELLRKKY GSSASSRVVA TTDSSKGVLK 

       190        200        210        220        230        240 
KFADSEKLDT FTIPDNVGGR YSVLTPVGLF PLAVAGISIS KFILGFQNIL NDIHSITDPT 

       250        260        270        280        290        300 
RNPATYYSAL RNYFLSEGRY IEVLANFNPS LRYVSEWWKQ LFGESEGKEN KGIFPASMDF 

       310        320        330        340        350        360 
TTDLHSLGQY IQEGKRILFE TVLSPSEVCS NLTLKPTQDN LDSLNFLSGN TLGYVNEQAR 

       370        380        390        400        410        420 
LGTLLAHADG GVPCLELVFP DISPQSLGEL MYFFEYSCAI SGYSLGVNPF DQPGVEAYKK 

       430        440 
NMFALLNKPG FEQEGETLRK RISRN

« Hide

References

[1]"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing."
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. expand/collapse author list , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.
Nature 422:888-893(2003) [PubMed: 12712204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 56601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010300 Genomic DNA. Translation: AAN51086.1.
RefSeqNP_714068.1. NC_004342.2.

3D structure databases

ProteinModelPortalQ8EZG6.
SMRQ8EZG6. Positions 2-442.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1153230.
GenomeReviewsGene locus LA_3888 in contig AE010300_GR.
KEGGlil:LA_3888.
PATRIC22388601. VBILepInt91350_3855.

Phylogenomic databases

HOGENOMHBG615843.
OMADNLDGLN.
PhylomeDBQ8EZG6.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycLINT-130-01:LINT-130-01-003014-MONOMER.
LINT189518:LA3887-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LEPIN
AccessionPrimary (citable) accession number: Q8EZG6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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