pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
ATP-dependent 6-phosphofructokinase (pfkA)
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	284	Proton donorUniRule annotation	1
Active siteⁱ	305	UniRule annotation	1
Active siteⁱ	419	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-KW
glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCycⁱ	LINT189518:G1GL4-3076-MONOMER
UniPathwayⁱ	UPA00109; UER00181

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:LA_3888
Organismⁱ	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifierⁱ	189518 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Leptospirales › Leptospiraceae › Leptospira › Leptospira interrogans › Leptospira interrogans serovar Lai
Proteomesⁱ	UP000001408 Componentⁱ: Chromosome I

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000180665	1 – 445	Glucose-6-phosphate isomeraseAdd BLAST		445

Proteomic databases

PRIDEⁱ	Q8EZG6

PRIDEⁱ

Q8EZG6

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	189518.LA_3888

STRINGⁱ

189518.LA_3888

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8EZG6
SMRⁱ	Q8EZG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107QYV Bacteria COG0166 LUCA
HOGENOMⁱ	HOG000100403
InParanoidⁱ	Q8EZG6
KEGG Orthology (KO) More...KOⁱ	K01810
OMAⁱ	SFIIPDD

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit
HAMAPⁱ	MF_00473 G6P_isomerase, 1 hit
InterProⁱ	View protein in InterPro IPR001672 G6P_Isomerase IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2
PANTHERⁱ	PTHR11469 PTHR11469, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342 PGI, 1 hit
PRINTSⁱ	PR00662 G6PISOMERASE
PROSITEⁱ	View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8EZG6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIRLETRFAS SFIQSSKLEP FLEKSESARL TLHSSQGQGK EYLGWLYLPK 
        60         70         80         90        100
ELKNSEIERM TQVAERLRNS SEVIVVIGIG GSYLGSRAVL EATLPFFKKP 
       110        120        130        140        150
SIGNPEIIFA GHHLESRYFS ELIEYLEDKN FSINVISKSG TTTEPAIAFR 
       160        170        180        190        200
LLWELLRKKY GSSASSRVVA TTDSSKGVLK KFADSEKLDT FTIPDNVGGR 
       210        220        230        240        250
YSVLTPVGLF PLAVAGISIS KFILGFQNIL NDIHSITDPT RNPATYYSAL 
       260        270        280        290        300
RNYFLSEGRY IEVLANFNPS LRYVSEWWKQ LFGESEGKEN KGIFPASMDF 
       310        320        330        340        350
TTDLHSLGQY IQEGKRILFE TVLSPSEVCS NLTLKPTQDN LDSLNFLSGN 
       360        370        380        390        400
TLGYVNEQAR LGTLLAHADG GVPCLELVFP DISPQSLGEL MYFFEYSCAI 
       410        420        430        440 
SGYSLGVNPF DQPGVEAYKK NMFALLNKPG FEQEGETLRK RISRN

Length:445

Mass (Da):49,735

Last modified:March 1, 2003 - v1

Checksum:ⁱ5ACA2EAC6387A6A9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE010300 Genomic DNA Translation: AAN51086.1
NCBI Reference Sequences More...RefSeqⁱ	NP_714068.1, NC_004342.2 WP_000620160.1, NC_004342.2

Genome annotation databases

EnsemblBacteriaⁱ	AAN51086; AAN51086; LA_3888
GeneIDⁱ	1153230
KEGGⁱ	lil:LA_3888
PATRICⁱ	fig\|189518.3.peg.3855

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8EZG6	Q72MT7 A0A1B9FL13 A0A163QRH3 M6ZGZ4 M3EYC0 A0A1N6VA20 A0A0E2D5W1 A0A0E2CUT5 M6KMS0 A0A0C5X808 +11	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) Leptospira interrogans serovar Canicola Leptospira interrogans serovar Pomona Leptospira interrogans serovar Pyrogenes str. 200701872 Leptospira interrogans serovar Lora str. TE 1992 Leptospira interrogans Leptospira interrogans str. UI 12758 Leptospira interrogans serovar Bataviae str. L1111 Leptospira interrogans serovar Pyrogenes str. L0374 Leptospira interrogans serovar Linhai str. 56609 And more	445	UniRef100_Q72MT7	Cluster: Glucose-6-phosphate isomerase	22

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8EZG6	Q72MT7 A0A1B9FL13 A0A163QRH3 M6ZGZ4 M3EYC0 A0A1N6VA20 A0A0E2D5W1 A0A0E2CUT5 M6KMS0 A0A0C5X808 +45	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) Leptospira interrogans serovar Canicola Leptospira interrogans serovar Pomona Leptospira interrogans serovar Pyrogenes str. 200701872 Leptospira interrogans serovar Lora str. TE 1992 Leptospira interrogans Leptospira interrogans str. UI 12758 Leptospira interrogans serovar Bataviae str. L1111 Leptospira interrogans serovar Pyrogenes str. L0374 Leptospira interrogans serovar Linhai str. 56609 And more	445	UniRef90_Q72MT7	Cluster: Glucose-6-phosphate isomerase	56

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8EZG6	Q8R924 UPI0005C723AF A0A101E6X2 U5CW27 UPI00047A72FF A0A1I1UPG7 UPI00048173F4 A0A1V6BL55 UPI0005CC27FF UPI000C156688 +278	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) Caldanaerobacter subterraneus Caldanaerobacter subterraneus subsp. yonseiensis KB-1 Caldanaerobius polysaccharolyticus Thermophagus xiamenensis Fusobacterium perfoetens Tenericutes bacterium ADurb.Bin140 Risungbinella massiliensis Parabacteroides sp. Marseille-P3668 Parabacteroides chinchillae And more	451	UniRef50_Q8R924	Cluster: Glucose-6-phosphate isomerase	289

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE010300 Genomic DNA Translation: AAN51086.1
NCBI Reference Sequences More...RefSeqⁱ	NP_714068.1, NC_004342.2 WP_000620160.1, NC_004342.2

3D structure databases

ProteinModelPortalⁱ	Q8EZG6
SMRⁱ	Q8EZG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	189518.LA_3888

STRINGⁱ

189518.LA_3888

Proteomic databases

PRIDEⁱ	Q8EZG6

PRIDEⁱ

Q8EZG6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAN51086; AAN51086; LA_3888
GeneIDⁱ	1153230
KEGGⁱ	lil:LA_3888
PATRICⁱ	fig\|189518.3.peg.3855

Phylogenomic databases

eggNOGⁱ	ENOG4107QYV Bacteria COG0166 LUCA
HOGENOMⁱ	HOG000100403
InParanoidⁱ	Q8EZG6
KEGG Orthology (KO) More...KOⁱ	K01810
OMAⁱ	SFIIPDD

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181
BioCycⁱ	LINT189518:G1GL4-3076-MONOMER

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit
HAMAPⁱ	MF_00473 G6P_isomerase, 1 hit
InterProⁱ	View protein in InterPro IPR001672 G6P_Isomerase IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2
PANTHERⁱ	PTHR11469 PTHR11469, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342 PGI, 1 hit
PRINTSⁱ	PR00662 G6PISOMERASE
PROSITEⁱ	View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_LEPIN
Accessionⁱ	Q8EZG6Primary (citable) accession number: Q8EZG6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
	Last sequence update:	March 1, 2003
	Last modified:	February 28, 2018
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8EZG6 (G6PI_LEPIN)

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ