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Q8EZG6

- G6PI_LEPIN

UniProt

Q8EZG6 - G6PI_LEPIN

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei284 – 2841Proton donorUniRule annotation
    Active sitei305 – 3051UniRule annotation
    Active sitei419 – 4191UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciLINT189518:GJBB-3084-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:LA_3888
    OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
    Taxonomic identifieri189518 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001408: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Glucose-6-phosphate isomerasePRO_0000180665Add
    BLAST

    Proteomic databases

    PaxDbiQ8EZG6.

    Interactioni

    Protein-protein interaction databases

    STRINGi189518.LA3888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EZG6.
    SMRiQ8EZG6. Positions 2-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiAIAFREF.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EZG6-1 [UniParc]FASTAAdd to Basket

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    MIRLETRFAS SFIQSSKLEP FLEKSESARL TLHSSQGQGK EYLGWLYLPK    50
    ELKNSEIERM TQVAERLRNS SEVIVVIGIG GSYLGSRAVL EATLPFFKKP 100
    SIGNPEIIFA GHHLESRYFS ELIEYLEDKN FSINVISKSG TTTEPAIAFR 150
    LLWELLRKKY GSSASSRVVA TTDSSKGVLK KFADSEKLDT FTIPDNVGGR 200
    YSVLTPVGLF PLAVAGISIS KFILGFQNIL NDIHSITDPT RNPATYYSAL 250
    RNYFLSEGRY IEVLANFNPS LRYVSEWWKQ LFGESEGKEN KGIFPASMDF 300
    TTDLHSLGQY IQEGKRILFE TVLSPSEVCS NLTLKPTQDN LDSLNFLSGN 350
    TLGYVNEQAR LGTLLAHADG GVPCLELVFP DISPQSLGEL MYFFEYSCAI 400
    SGYSLGVNPF DQPGVEAYKK NMFALLNKPG FEQEGETLRK RISRN 445
    Length:445
    Mass (Da):49,735
    Last modified:March 1, 2003 - v1
    Checksum:i5ACA2EAC6387A6A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010300 Genomic DNA. Translation: AAN51086.1.
    RefSeqiNP_714068.1. NC_004342.2.

    Genome annotation databases

    EnsemblBacteriaiAAN51086; AAN51086; LA_3888.
    GeneIDi1153230.
    KEGGilil:LA_3888.
    PATRICi22388601. VBILepInt91350_3855.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010300 Genomic DNA. Translation: AAN51086.1 .
    RefSeqi NP_714068.1. NC_004342.2.

    3D structure databases

    ProteinModelPortali Q8EZG6.
    SMRi Q8EZG6. Positions 2-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189518.LA3888.

    Proteomic databases

    PaxDbi Q8EZG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN51086 ; AAN51086 ; LA_3888 .
    GeneIDi 1153230.
    KEGGi lil:LA_3888.
    PATRICi 22388601. VBILepInt91350_3855.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi AIAFREF.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci LINT189518:GJBB-3084-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 56601.

    Entry informationi

    Entry nameiG6PI_LEPIN
    AccessioniPrimary (citable) accession number: Q8EZG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3