UniProtKB - Q8EZG6 (G6PI_LEPIN)
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Protein
Glucose-6-phosphate isomerase
Gene
pgi
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Functioni
Catalytic activityi
D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation
: glycolysis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Glucose-6-phosphate isomerase (pgi)
- ATP-dependent 6-phosphofructokinase (pfkA)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 284 | Proton donorUniRule annotation | 1 | |
Active sitei | 305 | UniRule annotation | 1 | |
Active sitei | 419 | UniRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphate isomerase activity Source: UniProtKB-EC
GO - Biological processi
- gluconeogenesis Source: UniProtKB-KW
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Gluconeogenesis, Glycolysis |
Enzyme and pathway databases
BioCyci | LINT189518:G1GL4-3076-MONOMER |
UniPathwayi | UPA00109; UER00181 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation |
Gene namesi | Name:pgiUniRule annotation Ordered Locus Names:LA_3888 |
Organismi | Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) |
Taxonomic identifieri | 189518 [NCBI] |
Taxonomic lineagei | Bacteria › Spirochaetes › Leptospirales › Leptospiraceae › Leptospira › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180665 | 1 – 445 | Glucose-6-phosphate isomeraseAdd BLAST | 445 |
Proteomic databases
PRIDEi | Q8EZG6 |
Structurei
3D structure databases
ProteinModelPortali | Q8EZG6 |
SMRi | Q8EZG6 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GPI family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4107QYV Bacteria COG0166 LUCA |
HOGENOMi | HOG000100403 |
InParanoidi | Q8EZG6 |
KOi | K01810 |
OMAi | SFIIPDD |
Family and domain databases
CDDi | cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit |
HAMAPi | MF_00473 G6P_isomerase, 1 hit |
InterProi | View protein in InterPro IPR001672 G6P_Isomerase IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2 |
PANTHERi | PTHR11469 PTHR11469, 1 hit |
Pfami | View protein in Pfam PF00342 PGI, 1 hit |
PRINTSi | PR00662 G6PISOMERASE |
PROSITEi | View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8EZG6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRLETRFAS SFIQSSKLEP FLEKSESARL TLHSSQGQGK EYLGWLYLPK
60 70 80 90 100
ELKNSEIERM TQVAERLRNS SEVIVVIGIG GSYLGSRAVL EATLPFFKKP
110 120 130 140 150
SIGNPEIIFA GHHLESRYFS ELIEYLEDKN FSINVISKSG TTTEPAIAFR
160 170 180 190 200
LLWELLRKKY GSSASSRVVA TTDSSKGVLK KFADSEKLDT FTIPDNVGGR
210 220 230 240 250
YSVLTPVGLF PLAVAGISIS KFILGFQNIL NDIHSITDPT RNPATYYSAL
260 270 280 290 300
RNYFLSEGRY IEVLANFNPS LRYVSEWWKQ LFGESEGKEN KGIFPASMDF
310 320 330 340 350
TTDLHSLGQY IQEGKRILFE TVLSPSEVCS NLTLKPTQDN LDSLNFLSGN
360 370 380 390 400
TLGYVNEQAR LGTLLAHADG GVPCLELVFP DISPQSLGEL MYFFEYSCAI
410 420 430 440
SGYSLGVNPF DQPGVEAYKK NMFALLNKPG FEQEGETLRK RISRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE010300 Genomic DNA Translation: AAN51086.1 |
RefSeqi | NP_714068.1, NC_004342.2 WP_000620160.1, NC_004342.2 |
Genome annotation databases
EnsemblBacteriai | AAN51086; AAN51086; LA_3888 |
GeneIDi | 1153230 |
KEGGi | lil:LA_3888 |
PATRICi | fig|189518.3.peg.3855 |
Similar proteinsi
Entry informationi
Entry namei | G6PI_LEPIN | |
Accessioni | Q8EZG6Primary (citable) accession number: Q8EZG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 28, 2018 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |