Q8EZG6 (G6PI_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	LA_3888

Organism

Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) [Reference proteome] [HAMAP]

Taxonomic identifier

189518 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Leptospiraceae › Leptospira › Leptospira interrogans › Leptospira interrogans serovar Lai

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-HAMAP glycolysis Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Glucose-6-phosphate isomerase HAMAP-Rule MF_00473		PRO_0000180665
Sites
	Active site	284	1	Proton donor By similarity
	Active site	305	1	By similarity
	Active site	419	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EZG6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5ACA2EAC6387A6A9	FASTA	445	49,735
	10 20 30 40 50 60 MIRLETRFAS SFIQSSKLEP FLEKSESARL TLHSSQGQGK EYLGWLYLPK ELKNSEIERM 70 80 90 100 110 120 TQVAERLRNS SEVIVVIGIG GSYLGSRAVL EATLPFFKKP SIGNPEIIFA GHHLESRYFS 130 140 150 160 170 180 ELIEYLEDKN FSINVISKSG TTTEPAIAFR LLWELLRKKY GSSASSRVVA TTDSSKGVLK 190 200 210 220 230 240 KFADSEKLDT FTIPDNVGGR YSVLTPVGLF PLAVAGISIS KFILGFQNIL NDIHSITDPT 250 260 270 280 290 300 RNPATYYSAL RNYFLSEGRY IEVLANFNPS LRYVSEWWKQ LFGESEGKEN KGIFPASMDF 310 320 330 340 350 360 TTDLHSLGQY IQEGKRILFE TVLSPSEVCS NLTLKPTQDN LDSLNFLSGN TLGYVNEQAR 370 380 390 400 410 420 LGTLLAHADG GVPCLELVFP DISPQSLGEL MYFFEYSCAI SGYSLGVNPF DQPGVEAYKK 430 440 NMFALLNKPG FEQEGETLRK RISRN

References

[1]

"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing." Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P. Nature 422:888-893(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 56601.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE010300 Genomic DNA. Translation: AAN51086.1.
RefSeq	NP_714068.1. NC_004342.2.
3D structure databases
ProteinModelPortal	Q8EZG6.
SMR	Q8EZG6. Positions 2-442.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	189518.LA3888.
Proteomic databases
PaxDb	Q8EZG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN51086; AAN51086; LA_3888.
GeneID	1153230.
KEGG	lil:LA_3888.
PATRIC	22388601. VBILepInt91350_3855.
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000100403.
KO	K01810.
OMA	FGIINIS.
OrthoDB	EOG64R61J.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	LINT189518:GJBB-3084-MONOMER.
UniPathway	UPA00109; UER00181.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase.
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_LEPIN

Accession

Primary (citable) accession number: Q8EZG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	March 1, 2003
Last modified:	February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program