ID   Q8EZ52_LEPIN            Unreviewed;      1396 AA.
AC   Q8EZ52;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN51206.1};
GN   OrderedLocusNames=LA_4008 {ECO:0000313|EMBL:AAN51206.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN51206.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN51206.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN51206.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN51206.1; -; Genomic_DNA.
DR   RefSeq; NP_714188.1; NC_004342.2.
DR   RefSeq; WP_001066611.1; NC_004342.2.
DR   STRING; 189518.LA_4008; -.
DR   PaxDb; 189518-LA_4008; -.
DR   EnsemblBacteria; AAN51206; AAN51206; LA_4008.
DR   KEGG; lil:LA_4008; -.
DR   PATRIC; fig|189518.3.peg.3977; -.
DR   HOGENOM; CLU_004435_4_0_12; -.
DR   InParanoid; Q8EZ52; -.
DR   OrthoDB; 190810at2; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          44..185
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          323..399
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          954..987
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1396 AA;  157623 MW;  E1A9FA323704B2E0 CRC64;
     MNNTTESFKD TLELIRPYLP SGIVRRLANF GESKLQRSQS FEGAVLFFDV VGFTPTTLAL
     AAKGTRGIDA LQIVLSNYYT GLLKHLNEWG GAVYQFAGDS VLVSFEKREG ETAEEAALRV
     ANCALGISNS IAEYSSNELL GETVNLPARV GLAYGVYQEF ILGEQDRFLR AVIAGAPVDQ
     SIAAEKQALG GDIILSSSLW NLLPASKVGE NVNSDFFRLI DCEKCENSVP PPSRSTTEER
     FSDERFFKRC RRFIVPELYQ RVTSVHKAFS GDYREVASVF VRIDAPLESH SDSKNFNDFF
     IYVQSVAASC SGTFVLTDLS DKGGVFSVLF GAPAALENKE ALAARFAVRL MEGASNYSAA
     KNLQIGISTG MAYCGDLGAP FRKDFTAIGE MMNIAARLAT LSGYSGILID FQTKSKLGKN
     FSFHEVGDVE LKGVTGAKKV FQLTSEQKNI PGLLIQYKDK MIGRKEEIDR LHKMLDSSIE
     KGGVVCRIIA DAGLGKSRLT NTFIDQAYDR NVEILIGYCY PYEKFTPFYP WKELLSLFLG
     IFEDDSTEAR VAKAEKALEN LNSFDIAWAK ALVALMGVSV EEDPLTREID RKQKNERLFE
     IIISLLQERA NKKPLMLVFE DVHWIDELSS RLLEKLAFRL SEMKVMLLLV SRPEGQFGED
     SVAPNEELIR LKEFKSEEAK DFLIHKFKLD TSHEEFLDQI LNRSSGNPFF LESIVHNLIE
     EGTLIKLEDG TLSPSDKTRD IQIPNTLNDV LLARVDRLQE REKIVLKTAS VIGRLINVDT
     LNHLLPVEFR SQIDNILQSL EGLDLTPLEV TEPLTYIFKH IVIRDIVYNT LLHSTREDLH
     KKIASFIEKE NENNLTEMAD ILAFHYQQCS DFEKASKYSL MAARKARSKY ANRDAIYHYG
     KTLETLAQFE KTKSETYYEI KLELAHVHRQ FGEYSIAEVL FKECLENKST LNLIRSYTGL
     GQVYQEQDDI SRAMETLENA LRITGIRPPG SRPDTILKIV LQLTLVLRFS FFGPSYTSSN
     KAERLRLRCI ILATLAKMYI MKDVKKFGWS VFTQYNATQR FEDPVRSSLA ECALGQVFVG
     MNLFGPSKHF LLKGRELAEK TGDPYARAIS LLVQGGYYMM LNRPELGLPF LQDSISIYRQ
     VGEKWDLLSA LSSSGFLYYF QSDFRTAKQY FDDIGEIASD LGAQLQLRWT RIWSPYFGYL
     LGEVEPPELE KKLIVEVERA ASENDVMNEL STINKLLKLS ILEGWPEKAE LWARRSYAGF
     LKCEVKFPQL QIGNVYLAEA ALYAQMENGN KNLTKIINYG LKNGLKLGKS LPYLYGPSLV
     LKGKLLFHSG KRKKAEAIFK EAESFLSNTQ NRWEYATALY EIGELLGDTE RISTSKKILH
     ELGAKADLKR LDKIQL
//