ID   Q8EXU0_LEPIN            Unreviewed;       721 AA.
AC   Q8EXU0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAN51677.1};
GN   OrderedLocusNames=LB_118 {ECO:0000313|EMBL:AAN51677.1};
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN51677.1, ECO:0000313|Proteomes:UP000001408};
RN   [1] {ECO:0000313|EMBL:AAN51677.1, ECO:0000313|Proteomes:UP000001408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601 {ECO:0000313|EMBL:AAN51677.1,
RC   ECO:0000313|Proteomes:UP000001408};
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA   Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA   Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA   Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA   Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA   Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010301; AAN51677.1; -; Genomic_DNA.
DR   RefSeq; NP_714662.1; NC_004343.2.
DR   RefSeq; WP_000849131.1; NC_004343.2.
DR   AlphaFoldDB; Q8EXU0; -.
DR   STRING; 189518.LB_118; -.
DR   PaxDb; 189518-LB_118; -.
DR   EnsemblBacteria; AAN51677; AAN51677; LB_118.
DR   KEGG; lil:LB_118; -.
DR   PATRIC; fig|189518.3.peg.4448; -.
DR   HOGENOM; CLU_383467_0_0_12; -.
DR   InParanoid; Q8EXU0; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000001408; Chromosome II.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00028; TPR; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        201..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        350..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          458..594
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          657..690
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   721 AA;  82808 MW;  C195E380AA38EEE2 CRC64;
     MKTILFFFCV TIPFWILAES QDSWKPIDLR KGNWIAVEGF QREYLNGIDS TFSKSKKISH
     FPVVLNEIFE TSVETGLKEY TLQTRFHIQE DFQKTKVYKP IFLYLESIGE NWEIFLNDHS
     LAQEIHLDIS HKEMILRRTI RSFRLPVDSS LLRSGENLLT FRLIGDAPAS FLSKNVDLGF
     YIDGDYSLTT EQKLSGEIST LINLCLNTIY VFFGFYHLLI YVKRREDLYN LYFGIFSVFM
     ALYSLSRSNI AFEVIYDTTW ITRIEYSSVS LLAPLFLLFM QDYFYGRAKF SKVLFAILIL
     NVVIALTTLL EPFRYTMTSL RLWQISILPT LVYLLYFMSK AVYLRKKDAI LLATSMFTVV
     FIAVYDVIDS IFFQSGIRFT QFAYFLFVVA LTTILANRFI SLYRQSEDLN IELSQQKLEL
     ARQKNAFFRF VPVQFLNVLG KNSAVEVNLG DSVLKEMSVL FTDIRSFTTI SEQMTPEENF
     RFINDYLASM EPVVQRHEGF VDKFMGDGIL ALFSGDGEIT RSHQTSADKA ILAAIEMKKK
     VQTINAQAKD SHFRGLKIGI GINTGNLMLG TVGSRSRLDT TVIGDTVNVA SRLESLTNLY
     RADILITKST LSAMTIADNL AIREIDSVVV KGKTDPIIIY EIYEADEPLI RKLKDATLSL
     ITRGIILYKV ADFQEALINF EQALKIFPED IVPILYRKRC QEYITSPPTG NWVGVQHLLE
     K
//